Module 1: Immunology

Through a focus on autoimmune diseases, asthma, and vaccine responses (especially the influenza vaccine), this module gives learners the knowledge to:  

• Describe key epidemiological data associated with sex differences in the prevalence and outcomes of immunological disease, as well as vaccine efficacy and acceptance.
• Identify the tools available to study sex differences and their outcome measures in preclinical models.
• Describe clinical studies related to sex effects on therapeutic treatments of immunological disease, as well as the efficacy of vaccines.
• Recognize knowledge gaps and biases associated with our understanding of sex differences in immune responses.
   

Module 2: Cardiovascular Disease

This module explores sex and gender differences in cardiovascular disease via three major topics: heart failure with preserved ejection fraction (HFpEF), coronary microvascular dysfunction (CMD), and spontaneous coronary artery dissection (SCAD). After completing the module, learners will be able to:

• Identify gaps in research methodologies and public misconceptions associated with sex differences in cardiovascular disease.
• Identify sex differences in the presentation, risk factors, and pathophysiology of representative cardiovascular diseases.
• Describe how sex differences in risk factors and pathophysiology affect cardiovascular patient outcomes and disease management.
• Describe steps required to improve diagnosis and treatment of cardiovascular disease in women and men.
   

Module 3: Pulmonary Disease

The pulmonary disease module focuses on sex and gender differences in pulmonary diseases, including idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and pulmonary arterial hypertension (PAH). After completing the module, learners will be able to:

• Identify sex differences in the presentation, risk factors, and pathophysiology of pulmonary diseases. 
• Describe how sex differences in pulmonary risk factors and pathophysiology affect patient outcomes and disease management.
• Identify opportunities to address gaps in knowledge via future research efforts.
• Describe how insights from pulmonary research can inform research design in other fields of study.
   

Module 4: Neurology

With lessons on ischemic stroke, Parkinson’s disease, and epilepsy, this module explores sex differences in neurological diseases. After completing the module, learners will be able to:

• Recognize sex differences in prevalence, symptoms, and treatment effects for neurological diseases.
• Explain the relationship of sex, gender, and age in neurological diseases.
• Recognize hormonal effects on incidence, disease progression, and treatment outcomes.
• Describe preclinical findings on sex differences in neurological diseases.
   

Module 5: Endocrinology

The Endocrinology module presents information on sex and gender differences in three conditions: osteoporosis, Type 2 diabetes, and differentiated thyroid cancer. Learners will gain the knowledge to:

• Interpret the epidemiological data on endocrine and metabolic disorders and explain how prevalence and outcomes may differ based on sex. 
• Describe preclinical evidence supporting sex differences in endocrine and metabolic disorders and the mechanisms involved.
• Explain the impact of sex differences on the clinical presentation and treatment of endocrine and metabolic disorders.
• Detail the knowledge gaps in endocrine and metabolic research and develop ideas for future preclinical or clinical research studies.
    

Module 6: Mental Health

This module explores two mental health disorders with pronounced sex differences: major depressive disorder and autism spectrum disorder. After completing the module, learners will be able to:

• Identify sex and gender differences in the presentation, risk factors, and pathophysiology of mental health disorders.
• Characterize the epidemiology of mental health disorders, with a focus on sex as a relevant biological variable.
• Describe how preclinical models and clinical studies have provided greater understanding of pathology and mechanisms involved in mental health disorders and sex differences.
• Identify gaps in our understanding of sex differences in mental health disorders.