NIAAA’s Alcohol Research Resource (R24) Awards support investigator-initiated projects that develop resources to serve the broader alcohol-research community. Resources include biological specimens, animals, data, materials, tools, or services made available to any qualified investigator to accelerate alcohol-related research in a cost-effective manner.
Please send inquiries to the Principal Investigator listed below or contact the appropriate NIAAA Program Director.
Rodents with Genetic Differences in Alcohol Preference (U24 AA015512)
Goal of resource: To provide the resources needed to maintain colonies of alcohol preferring (P)and non-preferring (NP) rats and provide sufficient numbers of animals for investigators external to the Indiana Alcohol Research Center (IARC).
Contact PI: Richard Bell, Ph.D.
Indiana University
317-278-8407
NIH RePORTER Project Information
Clinical Resource for Lung and Alcohol Investigations (R24 AA019661)
Goal of resource: To determine the mechanisms whereby alcohol use disorders (AUDs) increase the predisposition to lung pathologies. Available biological specimens include bronchoalveolar lavage (BAL, fluid and cells), exhaled breath condensate (EBC); in some cases, bronchial airway epithelial cell (BAEC) brushings (cytologic, sometimes microbiologic), urine, plasma or serum, and peripheral blood mononuclear cells from well-characterized human subjects.
Contact PI: Ellen Burnham, MD
University of Colorado Denver
303-724-6078
NIH RePORTER Project Information
Mouse Genetic Models for Alcohol Excessive Drinking and Dependence (R24 AA020245)
Goal of resource: To maintain and provide access to selectively bred mouse lines for alcohol research. In addition, congenic strains and transgenic and knockout lines for quantitative trait locus (QTL) gene mapping studies are also maintained.
Contact PI: John Crabbe, Ph.D.
Oregon Health & Science University
503-273-5298
NIH RePORTER Project Information
Monkey Alcohol Tissue Research Resource (MATRR) (R24 AA019431)
Goal of resource: To provide the alcohol research community access to tissue and data generated from cohorts of monkeys that have been subjected to a voluntary alcohol self-administration protocol. Informatics resources for the MATRR include an integrated laboratory information management system for tissue tracking and data management and the development of a system for the integrated analysis of genomic, genetic and phenotypic information.
Contact PI: Kathleen Grant, Ph.D.
Oregon Health & Science University
503-614-3738
Website: www.matrr.com
NIH RePORTER Project Information
Enriching Alcoholism Cohort and Population Studies (R24 AA023487)
Goal of resource: To expand the Family Research Center (FRC) to enable testing of a broad array of research hypotheses about risk mechanisms in the onset, progression and remission of alcohol use disorders (AUD), as well as social/familial, physiological/genomic and medical consequences of AUD.
Contact PI: Andrew Heath, DPhil
Washington University
314-286-2203
NIH RePORTER Project Information
Clinical Resources for Alcoholic Hepatitis Investigations (R24 AA025017)
Goal of resource: To develop a clinical resource of severe alcoholic hepatitis (AH) that serve the alcohol research community by generating transcriptome and proteome databases from liver tissues from patients with severe AH and establishing a centralized database of de-identified samples for promoting access to otherwise unavailable specimens. Available biological specimens include de-identified human samples (liver tissues, hepatic cells, whole blood, PBMCs, serum, plasma) from patients with severe AH.
Contact PI: Zhaoli Sun, M.D., Ph.D.
Johns Hopkins University
410-614-0491
NIH RePORTER Project Information
RGAP: The Heritable Transcriptome and Alcoholism (R24 AA013162)
Goal of resource: To make available high quality genetic and whole genome microarray expression data (brain and other organs) from animal models of alcohol use disorders (AUDs) including recombinant inbred and inbred strains of mice and rats. Available online tools allow a user to identify candidate genes and transcriptional networks for complex physiological and behavioral traits based on the tenets of quantitative genetics, i.e., by combining transcript expression and phenotypic data with expression and behavioral QTL data.
Contact PI: Boris Tabakoff, Ph.D.
University of Colorado Denver
303-724-3668
Website: Phenogen.ucdenver.edu
NIH RePORTER Project Information
Integrative Liver Cell Core (R24 AA012885)
Goal of resource: To promote in-depth research on different liver cell types which are involved in various spectra of liver pathology in alcoholic liver disease (ALD) and liver fibrosis via isolation and culturing of 6 different liver cell types from normal and diseased rodent livers. Available specimens include hepatocytes, hepatic macrophages, hepatic stellate cells, liver mesothelial cells, and liver sinusoidal endothelial cells.
Contact PI: Hidekazu Tsukamoto, DVM, Ph.D.
University of Southern California
323-442-5107
NIH RePORTER Project Information
Mouse Models for Alcohol Metabolism and Tissue Injury (R24 AA022057)
Goal of resource: To maintain and make available transgenic knockout animal models that are unique and have high relevance to alcohol research. Current models include conventional and tissue-specific conditional knockouts of various alcohol-metabolizing and glutathione-synthesizing enzymes. Ethanol/acetaldehyde pharmacokinetic analysis for each knockout produced are provided including a description of the methodology used. New models will be added as these become available.
Contact PI: Vasilis Vasiliou, Ph.D.
Yale University
203-737-8094
NIH RePORTER Project Information
Integrative Liver Cell Core (R24 AA012885)
Goal of resource: To promote in-depth research on different liver cell types which are involved in various spectra of liver pathology in alcoholic liver disease (ALD) and liver fibrosis via isolation and culturing of 6 different liver cell types from normal and diseased rodent livers. Available specimens include hepatocytes, hepatic macrophages, hepatic stellate cells, liver mesothelial cells, and liver sinusoidal endothelial cells.
Contact PI: Hidekazu Tsukamoto, DVM, Ph.D.
University of Southern California
323-442-5107
NIH RePORTER Project Information
Center for Circadian Rhythms and Alcohol-Induced Tissue Damage (CCRAITD) (R24 AA026801-01A1)
Goal of resource: The objective of the CCRAITD is to provide the necessary infrastructure, support, and expertise that will allow both alcohol researchers in the United States and internationally to incorporate the study of circadian rhythms into their existing research programs. The Resource Center will allow alcohol researchers to conduct studies in the Center’s facility at Rush University, and will be provided with biospecimens from their study to evaluate study-specific outcomes. CCRAITD will also provide biospecimens from alcohol-fed, circadian disrupted mice and circadian disrupted humans consuming alcohol, and biospecimens from CCRAITD biorepository to alcohol researchers.
Contact PI: Ali Keshavarzian, Ph.D.
Rush University Medical Center
312 563-4175
Website: http://www.rushu.rush.edu/ccar
NIH RePORTER Project Information