Investigational New Animal Drugs (INADs)

Investigational New Animal Drugs (INADs) are drugs that are in the approval pipeline but are not yet approved by FDA for use in the United States. Participation in the AADAP National INAD Program requires enrolling in the program which allows access to one or all of the drugs listed below. For more information on available INADs, what they can be used for, and what data/information that you will be required to submit, visit the links below.  

How to Enroll in the Investigational New Animal Drug (INAD) Program: A video tutorial that outlines the process of enrollment for study monitors and study investigators.   

INAD U:  Information to help those individuals new to the program (i.e., freshman level) as well as those who have participated for a long time (i.e., senior), and everyone in-between.  

For further assistance, please contact the AADAP program.   

Medicated Feeds

• Florfenicol (Aquaflor®) INAD #10-697
  Aquaflor® is an aquaculture premix containing florfenicol and is only available through Merck Animal Health. The primary goal of field studies conducted under INAD #10-697 is to evaluate the efficacy of florfenicol-medicated feed for controlling mortality in a variety of fish species diagnosed with a variety of diseases that are caused by pathogens susceptible to florfenicol. More »


• Slice® (Emamectin Benzoate) INAD #11-370
  SLICE® is an aquaculture premix containing emamectin benzoate and is only available through Merck Animal Health. SLICE® premix can be purchased through Merck Animal Health and sent to an aquaculture feed mill for top coating. More »


• Oxytetracylcine dihydrate (Terramycin® 200 for Fish) INAD #9332
  Terramycin 200® for fish is an aquaculture premix containing oxytetracycline dehydrate (OTC) and is available through Syndel USA. OTC medicated feed can be purchased from aquaculture feed mills. OTC medicated feed can be used to treat bacterial diseases or to apply a skeletal mark on the fish. More »


• 17α-methyltestosterone INAD #11-236
  17α-methyltestosterone (MET) is an aquaculture premix and is only available through Rangen Inc. The primary goal of studies conducted under INAD #11-236 is to generate data evaluating the efficacy of MET administered in feed to larval tilapia to produce populations comprised of >90% male fish.
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• 17α-methyltestosterone INAD #8557
  17α-methyltestosterone (MET) is an aquaculture premix and is only available through Rangen Inc. The primary goal of studies conducted under INAD #8557 is to generate data evaluating the efficacy of MET administered in feed to larval rainbow trout and Atlantic salmon to produce masculinized female fish that produce sperm. More »


• 17β-Estradiol INAD #12-671
  17β -estradiol (E2) will be administered as a medicated feed and is only available to FDA approved facilities. The primary goal of studies conducted under INAD #12-671 is to generate data evaluating the efficacy of E2 administered in feed to larval brook trout to produce feminized male fish that produce eggs. More »


• Oxytetracycline for Shrimp INAD #8069
  Terramycin 200® for shrimp is an aquaculture premix containing oxytetracycline dehydrate (OTC) and is available through Syndel USA. OTC medicated feed can be purchased from aquaculture feed mills. More »


• Florfenicol (Aquaflor®) for Lobsters INAD #12-061
  Aquaflor® is an aquaculture premix containing florfenicol and is only available through Merck Animal Health. Aquaflor® medicated feed can be purchased through aquaculture feed mills. The primary goal of field studies conducted under INAD #10-697 is to evaluate the efficacy of florfenicol-medicated feed for controlling mortality in lobsters (Nephropidae and Palinuridae) with a variety of diseases that are caused by pathogens susceptible to florfenicol. More »

State INAD participant using the Aqui-S 20E INAD to sedate fish for surgery. Photo Credit: Ryan Mann/ Arizona Game and Fish

Immersion

• Chloramine-T INAD #9321
  Chloramine-T (CLT) is a powder that is applied as an immersion bath treatment. CLT is only available for purchase through Syndel USA or B.L. Mitchell, Inc. The primary goal of field studies conducted under INAD #9321 is to evaluate the efficacy of CLT for controlling mortality in a variety of freshwater fish species for bacterial diseases not currently listed on the approved label. More »


• Hydrogen peroxide (35% Perox Aid®) INAD #11-669
  35% Perox-Aid® (H2O2) is a liquid solution containing hydrogen peroxide that is applied as an immersion bath treatment. H2O2 is only available for purchase through Syndel USA. The primary goal of field studies conducted under INAD #11-669 is to evaluate the efficacy of H2O2 for controlling mortality caused by specific ectoparasites in freshwater or marine finfish species. More »


• Oxytetracycline hydrochloride INAD #9033
  Oxytetracycline hydrochloride (OTIMM) is an aquaculture premix containing oxytetracycline hydrochloride and is available through Pharmagate. OTIMM is available for purchase through many local farm & ranch stores or veterinarian supply outlets. More »


• Diquat® INAD #10-969
  Reward® (DQT) is a liquid concentrate containing diquat dibromide that is applied as an immersion bath treatment. DQT is available for purchase through many local farm & ranch stores or through Syngenta Crop Protection, LLC. The primary goal of field studies conducted under INAD #10-969 is to evaluate the efficacy of DQT for controlling mortality in all freshwater-reared finfish diagnosed with BGD or external flavobacteriosis. More »

Sedatives

• AQUI-S®20E INAD #11-741
  Aqui-S®20E is a liquid containing 10% eugenol that is applied as an immersion bath treatment. Aqui-S®20E is only available for purchase through AquaTactics Fish Health / AQATAQ Vaccines. The primary goal of field studies conducted under INAD #11-741 is to evaluate the efficacy of Aqui-S®20E for use as an anesthetic/sedative in all freshwater-reared finfish, freshwater prawn, all saltwater-reared finfish, and sharks. More »

Injecting the hormone into a ripe striped bass. All striped bass, males and females, are injected with a pellet hormone to induce spawning. Credit: Warm Springs Regional Fishery Center, GA\USFWS.

Spawning Aids

• Lutenizing Hormone – Releasing Hormone (LHRHa) INAD #8061
  Luteinizing Hormone - Releasing Hormone analogue (LHRHa) is a solution that is applied as either an intraperitoneal (IP) or intramuscular (IM) injection. LHRHa is only available for purchase through Syndel USA. The use of hormones to induce spawning in fish is critical to the success of many aquatic programs that needs hormone treatment to complete final gamete maturation to ensure spawning. More »


• GnRH IIa Chicken Gonadotropin – Releasing Hormone II analog INAD #13-345
  GnRH IIa is a synthetic peptide analogue of chicken gonadotropin-releasing hormone (cGnRH IIa). It is presented as a dry powder to be resuspended in saline solution for intraperitoneal (IP) injection and is only available for purchase through AquaTactics Fish Health. The use of hormones to induce spawning in fish is critical to the success of many aquatic programs that need hormone treatment to complete final gamete maturation to ensure spawning. More »


• Ovaplant® Salmon Gonadotropin – Releasing Hormone analoque (sGnRHa) INAD #11-375
  Ovaplant® is a synthetic peptide analogue of salmon gonadotropin-releasing hormone (sGnRHa). It is presented in a bidegradable cholesterol-based matrix as an intramuscular pellet implant and is only available for purchase through Syndel USA. The use of hormones to induce spawning in fish is critical to the success of many aquatic programs that needs hormone treatment to complete final gamete maturation to ensure spawning. More »


• Ovaplant®-L Salmon Gonadotropin – Releasing Hormone analoque (sGnRHa) INAD #13-298
  Ovaplant®-L is a synthetic peptide analogue of salmon gonadotropin-releasing hormone (sGnRHa).It is presented in a sustained release gel for injection and is only available for purchase through Syndel USA. The use of hormones to induce spawning in fish is critical to the success of many aquatic programs that needs hormone treatment to complete final gamete maturation to ensure spawning. More »


• OvaRH® Salmon Gonadotropin – Releasing Hormone analogue (sGnRHa) INAD #12-186
  OvaRH® is a synthetic peptide analogue of salmon gonadotropin-releasing hormone (sGnRHa). It is presented as a soluble powder for dissolution in saline as an injection either as an intraperitoneal (IP) or intramuscular (IM) injection. OvaRH® is only available for purchase through Syndel USA. The use of hormones to induce spawning in fish is critical to the success of many aquatic programs that needs hormone treatment to complete final gamete maturation to ensure spawning. More »


• Common Carp Pituitary (CCP) INAD #8391
  Common carp pituitary (CCP) is a powder (for suspension) that is applied as either an intraperitoneal (IP) or intramuscular (IM) injection. CCP is only available for purchase through Argent Aquaculture. The use of hormones to induce spawning in fish is critical to the success of many aquatic programs that need hormone treatment to complete final gamete maturation to ensure spawning. More »


• Channel Catfish Pituitary (CP) INAD #11-468
  Channel catfish pituitary (CP) is a powder (for suspension) that is applied as either an intraperitoneal (IP) or intramuscular (IM) injection. CP is only available for purchase through Hybrid Catfish Company. The use of hormones to induce spawning in fish is critical to the success of many aquatic programs that needs hormone treatment to complete final gamete maturation to ensure spawning. More »

Marking

• Calcein (Se-Mark®) INAD #10-987
  Calcein (Se-Mark®) is a liquid that contains 1% calcein for bath marking treatments on finfish and select freshwater mussels. Calcein is only available for purchase through Syndel USA. Calcein is a fluorochrome compound that chemically binds with alkaline earth metals such as calcium, and upon binding, shows a marked increase in fluorescence when excited with blue light of about 500 nm wavelength. More »

Injectable

• Erythromycin 200 Injectable INAD #12-781
  ERYMICIN 200 Injection (Erymicin 200) is a solution that contains erythromycin for injection on juvenile and adult Salmonids. Erymicin 200 is only available for purchase through Syndel USA. The primary goal of field studies conducted under INAD #12-781 is to evaluate the efficacy of erythromycin for 1) controlling mortality caused by BKD (causative agent: Renibacterium salmoninarum) in salmonid species; and 2) control the vertical transmission of R. salmoninarum from BKD positive female broodstock to eggs/progeny. More »