From the 1970s through the early 1990s, the Greenland Ice Sheet was roughly in balance, with mass gains equaling mass losses. In the mid‐1990s, however, Greenland ice loss began and accelerated. By combining ~1985–2015 records of changing outlet glacier flow, ice edge positions, and ice sheet surface elevation, we show that the margin of the Greenland Ice Sheet is undergoing a significant reconfiguration. Ice edge retreat is ubiquitous, with virtually no glaciers experiencing advance, while some areas of the ice sheet have sped up and others have slowed. Our observations reveal a rapid reconfiguration around the full ice sheet margin, with narrowing areas of fast ice flow, changes in the routing of ice flow, and glacier outlets that are likely being abandoned. The implications of rapid ice sheet reconfiguration are wide ranging. Water movement underneath the ice sheet likely changes, along with the quantity and timing of iceberg production and freshwater input to the ocean, affecting the nutrients and sediment transport from the ice sheet to local and regional ecosystems. Without detailed observations of earlier deglaciations and with limits on ice sheet computer simulation capabilities, these observational records provide an important analogue for past deglaciation and for projecting future ice loss.