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Address questions about passwords, submissions, testing, registration to:

Jonathan Zotalis
Project Manager
Contractor: NCI Chemotherapeutic Agents Repository
BioServices, Thermo Fisher Scientific
E-mail: jonathan.zotalis@nih.gov
Phone: 240.686.4724

If you have never used our online compound submission application, you will need to register with us as an online supplier, even if you have submitted compounds to us through another method before.

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Structures submitted through the compound submission application will be considered for testing in our in vitro anticancer screen. .

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News

NOTICE: NCI-60 testing operations will resume on August 17, 2020.
NCI-60 testing operations will resume on August 17, 2020. However, with the backlog of samples received prior to the COVID-19 related suspension of our operations in March, and the current queue of agents in the pipeline, please expect a delay in both the screening process and posting of test results. It is anticipated that the turnaround time for results will be well outside of our normal posting timeframe of 8-10 weeks until the situation reaches a steady state.
Notice: Update to the on line structure drawing program.
We have replaced the on line structure drawing program and are now using Chemdraw-JS. Users of older versions of Windows and Internet Explorer may notice some lag time when opening the application.
System update - Password reset notice.
As a consequence of the latest system update some user passwords have had to be reset. If your password is no longer working please use the 'Forgot Password' link on the left hand side of the page to re-set it. You must close your browser after requesting a reset before you enter your temporary or changed password. If you continue to have trouble please contact Kevin McCormack (mccormackk@mail.nih.gov) for assistance.
NOTICE: CDA signatories with private e-mail addresses will no longer be acceptable.
Signatories with personal e-mail addresses will no longer be permitted. All current signatories with personal e-mail addresses have been removed from the system. This will not affect currently signed CDA’s.
New Shipping Quotas
As of Monday December 17, 2018 a quota of five (5) packing lists per 30 day period has been implemented. In addition only ten (10) compounds may be added to any packing list.
Important, Please Read -- Shipping Compounds
For secure transit, and as a matter of safe handling of agents upon receipt, all compounds shipped to the National Cancer Institute - Chemotherapeutic Agents Repository for in vitro screening are required to be contained in well-sealed, glass or plastic vials that have a positive closure. Materials not in compliance with this standard will be directly disposed of upon receipt. Additionally, if a vial is received damaged and is deemed to have contaminated the package, the entire shipment may potentially be discarded as well.

In order to process agents for testing upon receipt, all vials must be labeled with the six-digit Temporary Identification (TID) assigned to the compound upon submission.

UPDATED 12/20 : Guidelines for Small Molecule Structures for Screening.
The Guidelines for Small Molecule Structures for Screening has been updated. Please read before submitting new structures.
CDA Information
The CDA is available for review at the following link: New NCI60 Screening CDA/MTA.

Users will need to provide the name and e-mail address of a signatory from their institution who has the authority to execute the agreement. Your submission will be reviewed by DTP only after the CDA/MTA has been agreed to by your signatory. If the CDA/MTA is declined or not acted upon after 30 days, the submission request will be deleted.

Attention IE Users
You must be using an Internet Explorer Version 7 or higher to use this application. If you encounter difficulties with the application please make sure that 'Compatibility Mode' is turned off. More information about Compatibility Mode

This warning banner provides privacy and security notices consistent with applicable federal laws, directives, and other federal guidance for accessing this Government system, which includes (1) this computer network, (2) all computers connected to this network, and (3) all devices and storage media attached to this network or to a computer on this network.

This system is provided for Government-authorized use only.

Unauthorized or improper use of this system is prohibited and may result in disciplinary action and/or civil and criminal penalties.

Personal use of social media and networking sites on this system is limited as to not interfere with official work duties and is subject to monitoring.

By using this system, you understand and consent to the following:
  • The Government may monitor, record, and audit your system usage, including usage of personal devices and email systems for official duties or to conduct HHS business. Therefore, you have no reasonable expectation of privacy regarding any communication or data transiting or stored on this system. At any time, and for any lawful Government purpose, the government may monitor, intercept, and search and seize any communication or data transiting or stored on this system.
  • Any communication or data transiting or stored on this system may be disclosed or used for any lawful Government purpose.

Nothing in the preceding language overrides or modifies in any way the terms of the Discreet Screening Agreement"

Useful resources (Please review the information carefully before contacting the program)