Cancer Currents: An NCI Cancer Research Blog
A blog featuring news and research updates from the National Cancer Institute.
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Stopping TKI Treatment Is Safe, Improves Quality of Life for Some with CMLFor adults with CML who are in a sustained deep molecular remission, stopping treatment with a tyrosine kinase inhibitor is safe and improves their quality of life, a study shows. But researchers cautioned that these patients must be closely monitored.
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Could Cholesterol-Lowering Drugs Improve Cancer Immunotherapy?Cholesterol-lowering drugs known as PCSK9 inhibitors may improve the effectiveness of cancer immune checkpoint inhibitors, according to studies in mice. The drugs appear to improve the immunotherapy drugs’ ability to find tumors and slow their growth.
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Nanoparticle Trains Immune Cells to Attack CancerResearchers have developed a nanoparticle that trains immune cells to attack cancer. According to the NCI-funded study, the nanoparticle slowed the growth of melanoma in mice and was more effective when combined with an immune checkpoint inhibitor.
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Cancer “Liquid Biopsy” Blood Test Gets Expanded FDA ApprovalFDA has expanded the approved uses of the FoundationOne Liquid CDx blood test, known as a liquid biopsy, that can help doctors pick specific treatments for some people with cancer. When used in this way, the test is known as a companion diagnostic.
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Targeted Radiation Reduces Pain from Cancer Metastases in the SpineFor some patients with painful spinal metastases from advanced cancer, a type of precise, high-dose radiation therapy—called stereotactic body radiation therapy (SBRT)—may be a highly effective way to relieve that pain, clinical trial results show.
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Persistent Poverty Linked to Increased Risk of Dying from CancerPeople who live in counties in the United States with persistent poverty are more likely to die from cancer than people in other counties, a new study shows, highlighting the influence of social and structural factors on health.
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People with Cancer Say Access to Their Clinical Notes Is ValuablePeople with cancer find significant value in having access to electronic clinical notes from their doctor visits, a new study shows. Expanded access to these “open notes” will soon be required under the 21st Century Cures Act.
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For Childhood Eye Cancer, Researchers Investigating “Packaged” CAR T CellsFor children with the eye cancer retinoblastoma, researchers are studying a CAR T-cell therapy in which the engineered immune cells are packaged in a biodegradable material called a hydrogel and then injected directly into tumors.
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Smoking Initiation Shifting from Teens to Young AdultsThe age at which people tend to start smoking has shifted upwards, with more young adults than teens trying smoking for the first time or becoming regular smokers, according to a new study.
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Why Is Colorectal Cancer Rising Rapidly among Young Adults?Diagnoses of colorectal cancer continue to increase in younger adults. In September 2020, more than 400 leading scientists and patient advocates participated in an NCI/NIEHS-sponsored symposium to identify research priorities that address important questions about this concerning trend.
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Radiopharmaceuticals: Radiation Therapy Enters the Molecular AgeResearchers are developing a new class of cancer drugs called radiopharmaceuticals, which deliver radiation therapy directly and specifically to cancer cells. This Cancer Currents story explores the research on these emerging therapies.
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Nivolumab Improves Survival for Some Patients with Advanced Stomach CancerFor some people with advanced stomach cancer, the drug nivolumab (Opdivo) plus chemotherapy may improve how long they live, results from a large clinical trial show. The trial also included patients with gastric cancers that involve the esophagus.
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For Esophageal Cancer, Immunotherapy Likely to Play Larger RoleFor some people with advanced esophageal cancer, the immunotherapy drugs pembrolizumab (Keytruda) and nivolumab (Opdivo) may become part of early treatment for the disease, according to results from two large clinical trials.
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FDA Approves Blood Tests That Can Help Guide Cancer TreatmentFDA has recently approved two blood tests, known as liquid biopsies, that gather genetic information to help inform treatment decisions for people with cancer. This Cancer Currents story explores how the tests are used and who can get the tests.
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Large Study Confirms that HPV Vaccine Prevents Cervical CancerWidespread HPV vaccine use dramatically reduces the number of women who will develop cervical cancer, according to a study of nearly 1.7 million women. Among girls vaccinated before age 17, the vaccine reduced cervical cancer incidence by 90%.
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Saying YES: Inspiring a Diverse Generation of Cancer ScientistsDrs. Ned Sharpless and Sanya Springfield highlight NCI’s YES program, which is encouraging young students from underrepresented populations to become interested and engaged in cancer research.
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A More Treatable Kind of Metastatic Cancer?People with oligometastatic cancer have only a few metastatic tumors. Researchers are studying whether treating these individual tumors directly with surgery or stereotactic body radiation therapy (SBTR or SABR) can help patients live longer or improve their quality of life.
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Study Reinforces Treatment Idea for Cancer with Microsatellite InstabilityCancer cells with a genetic feature called microsatellite instability-high (MSI-high) depend on the enzyme WRN to survive. A new NCI study explains why and reinforces the idea of targeting WRN as a treatment approach for MSI-high cancer.
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Melanoma Cells Are More Likely to Spread after a Stopover in Lymph NodesMelanoma cells that pass through the lymphatic system before entering the bloodstream are more resistant to cell death and spread more readily than cells that enter the bloodstream directly. The finding could lead to new treatment approaches.
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Reducing Cancer’s Global Burden: A Conversation with NCI’s Dr. Satish GopalDr. Satish Gopal, director of NCI’s Center for Global Health, discusses opportunities for making progress against cancer worldwide, particulary in low- and middle-income countries, many of which are seeing increasing cancer incidence and deaths.