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This Week in PNAS

Letters (Online Only)

  • Relevance of Kondo physics for the temperature dependence of the bulk modulus in plutonium

    • Marc Janoschek,
    • Gerry Lander,
    • Jon M. Lawrence,
    • E. D. Bauer,
    • Jason C. Lashley,
    • Mark Lumsden,
    • Douglas L. Abernathy,
    • and J. D. Thompson
    PNAS 2017 114 (3) E268; published ahead of print January 10, 2017, doi:10.1073/pnas.1618967114

  • Reply to Janoschek et al.: The excited δ-phase of plutonium

    • Albert Migliori,
    • Per Söderlind,
    • Alexander Landa,
    • Franz J. Freibert,
    • Boris Maiorov,
    • B. J. Ramshaw,
    • and Jon B. Betts
    PNAS 2017 114 (3) E269; published ahead of print January 10, 2017, doi:10.1073/pnas.1619207114

Science and Culture

How science intersects with culture.

  • Science and Culture: Searching for shared inspiration, artists head to the world’s largest science experiment

    • Amber Dance
    PNAS 2017 114 (3) 421-422; doi:10.1073/pnas.1619999114

Core Concepts

A brief introduction to emerging topics in science.

Commentaries

  • Astrocytes fuel the fire of lymphocyte toxicity after stroke

    • Meaghan Roy-O’Reilly and
    • Louise D. McCullough
    PNAS 2017 114 (3) 425-427; published ahead of print January 6, 2017, doi:10.1073/pnas.1619813114
    See companion article on page E396 in issue 3 of volume 114

  • When bottom-up meets top-down

    • Zvi Shtein and
    • Oded Shoseyov
    PNAS 2017 114 (3) 428-429; published ahead of print January 3, 2017, doi:10.1073/pnas.1619392114
    See companion article on page 451 in issue 3 of volume 114

  • When protected areas prove insufficient: Cheetah and “protection-reliant” species

    • Joshua R. Ginsberg
    PNAS 2017 114 (3) 430-431; published ahead of print January 9, 2017, doi:10.1073/pnas.1619817114
    See companion article on page 528 in issue 3 of volume 114

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

Perspective

  • Opportunity for marine fisheries reform in China

    • Ling Cao,
    • Yong Chen,
    • Shuanglin Dong,
    • Arthur Hanson,
    • Bo Huang,
    • Duncan Leadbitter,
    • David C. Little,
    • Ellen K. Pikitch,
    • Yongsong Qiu,
    • Yvonne Sadovy de Mitcheson,
    • Ussif Rashid Sumaila,
    • Meryl Williams,
    • Guifang Xue,
    • Yimin Ye,
    • Wenbo Zhang,
    • Yingqi Zhou,
    • Ping Zhuang,
    • and Rosamond L. Naylor
    PNAS 2017 114 (3) 435-442; published ahead of print January 17, 2017, doi:10.1073/pnas.1616583114

Physical Sciences

Applied Physical Sciences

  • Stochastic initiation and termination of calcium-mediated triggered activity in cardiac myocytes

    • Zhen Song,
    • Zhilin Qu,
    • and Alain Karma
    PNAS 2017 114 (3) E270-E279; published ahead of print January 3, 2017, doi:10.1073/pnas.1614051114
    OPEN ACCESS ARTICLE

  • Programming function into mechanical forms by directed assembly of silk bulk materials

    • Benedetto Marelli,
    • Nereus Patel,
    • Thomas Duggan,
    • Giovanni Perotto,
    • Elijah Shirman,
    • Chunmei Li,
    • David L. Kaplan,
    • and Fiorenzo G. Omenetto
    PNAS 2017 114 (3) 451-456; published ahead of print December 27, 2016, doi:10.1073/pnas.1612063114
    See Commentary on page 428 in issue 3 of volume 114

  • Matrix stiffening promotes a tumor vasculature phenotype

    • Francois Bordeleau,
    • Brooke N. Mason,
    • Emmanuel Macklin Lollis,
    • Michael Mazzola,
    • Matthew R. Zanotelli,
    • Sahana Somasegar,
    • Joseph P. Califano,
    • Christine Montague,
    • Danielle J. LaValley,
    • John Huynh,
    • Nuria Mencia-Trinchant,
    • Yashira L. Negrón Abril,
    • Duane C. Hassane,
    • Lawrence J. Bonassar,
    • Jonathan T. Butcher,
    • Robert S. Weiss,
    • and Cynthia A. Reinhart-King
    PNAS 2017 114 (3) 492-497; published ahead of print December 29, 2016, doi:10.1073/pnas.1613855114
    OPEN ACCESS ARTICLE

Biophysics and Computational Biology

  • Cell morphology drives spatial patterning in microbial communities

    • William P. J. Smith,
    • Yohan Davit,
    • James M. Osborne,
    • Wook Kim,
    • Kevin R. Foster,
    • and Joe M. Pitt-Francis
    PNAS 2017 114 (3) E280-E286; published ahead of print December 30, 2016, doi:10.1073/pnas.1613007114

Chemistry

  • Statistical mechanical model of gas adsorption in porous crystals with dynamic moieties

    • Cory M. Simon,
    • Efrem Braun,
    • Carlo Carraro,
    • and Berend Smit
    PNAS 2017 114 (3) E287-E296; published ahead of print January 3, 2017, doi:10.1073/pnas.1613874114
    OPEN ACCESS ARTICLE

  • Directional emission from dye-functionalized plasmonic DNA superlattice microcavities

    • Daniel J. Park,
    • Jessie C. Ku,
    • Lin Sun,
    • Clotilde M. Lethiec,
    • Nathaniel P. Stern,
    • George C. Schatz,
    • and Chad A. Mirkin
    PNAS 2017 114 (3) 457-461; published ahead of print January 4, 2017, doi:10.1073/pnas.1619802114

Computer Sciences

  • On-demand high-capacity ride-sharing via dynamic trip-vehicle assignment

    • Javier Alonso-Mora,
    • Samitha Samaranayake,
    • Alex Wallar,
    • Emilio Frazzoli,
    • and Daniela Rus
    PNAS 2017 114 (3) 462-467; published ahead of print January 3, 2017, doi:10.1073/pnas.1611675114
    OPEN ACCESS ARTICLE

Engineering

  • Imaging individual neurons in the retinal ganglion cell layer of the living eye

    • Ethan A. Rossi,
    • Charles E. Granger,
    • Robin Sharma,
    • Qiang Yang,
    • Kenichi Saito,
    • Christina Schwarz,
    • Sarah Walters,
    • Koji Nozato,
    • Jie Zhang,
    • Tomoaki Kawakami,
    • William Fischer,
    • Lisa R. Latchney,
    • Jennifer J. Hunter,
    • Mina M. Chung,
    • and David R. Williams
    PNAS 2017 114 (3) 586-591; published ahead of print January 3, 2017, doi:10.1073/pnas.1613445114
    OPEN ACCESS ARTICLE

Social Sciences

Social Sciences

  • On-demand high-capacity ride-sharing via dynamic trip-vehicle assignment

    • Javier Alonso-Mora,
    • Samitha Samaranayake,
    • Alex Wallar,
    • Emilio Frazzoli,
    • and Daniela Rus
    PNAS 2017 114 (3) 462-467; published ahead of print January 3, 2017, doi:10.1073/pnas.1611675114
    OPEN ACCESS ARTICLE

Sustainability Science

  • Ancient human disturbances may be skewing our understanding of Amazonian forests

    • Crystal N. H. McMichael,
    • Frazer Matthews-Bird,
    • William Farfan-Rios,
    • and Kenneth J. Feeley
    PNAS 2017 114 (3) 522-527; published ahead of print January 3, 2017, doi:10.1073/pnas.1614577114

Biological Sciences

Anthropology

  • Brain enlargement and dental reduction were not linked in hominin evolution

    • Aida Gómez-Robles,
    • Jeroen B. Smaers,
    • Ralph L. Holloway,
    • P. David Polly,
    • and Bernard A. Wood
    PNAS 2017 114 (3) 468-473; published ahead of print January 3, 2017, doi:10.1073/pnas.1608798114

Biochemistry

  • Structural characterization of nonactive site, TrkA-selective kinase inhibitors

    • Hua-Poo Su,
    • Keith Rickert,
    • Christine Burlein,
    • Kartik Narayan,
    • Marina Bukhtiyarova,
    • Danielle M. Hurzy,
    • Craig A. Stump,
    • Xufang Zhang,
    • John Reid,
    • Alicja Krasowska-Zoladek,
    • Srivanya Tummala,
    • Jennifer M. Shipman,
    • Maria Kornienko,
    • Peter A. Lemaire,
    • Daniel Krosky,
    • Amanda Heller,
    • Abdelghani Achab,
    • Chad Chamberlin,
    • Peter Saradjian,
    • Berengere Sauvagnat,
    • Xianshu Yang,
    • Michael R. Ziebell,
    • Elliott Nickbarg,
    • John M. Sanders,
    • Mark T. Bilodeau,
    • Steven S. Carroll,
    • Kevin J. Lumb,
    • Stephen M. Soisson,
    • Darrell A. Henze,
    • and Andrew J. Cooke
    PNAS 2017 114 (3) E297-E306; published ahead of print December 30, 2016, doi:10.1073/pnas.1611577114

  • Resolution of single and double Holliday junction recombination intermediates by GEN1

    • Rajvee Shah Punatar,
    • Maria Jose Martin,
    • Haley D. M. Wyatt,
    • Ying Wai Chan,
    • and Stephen C. West
    PNAS 2017 114 (3) 443-450; published ahead of print January 3, 2017, doi:10.1073/pnas.1619790114

  • MYH9 binds to lncRNA gene PTCSC2 and regulates FOXE1 in the 9q22 thyroid cancer risk locus

    • Yanqiang Wang,
    • Huiling He,
    • Wei Li,
    • John Phay,
    • Rulong Shen,
    • Lianbo Yu,
    • Baris Hancioglu,
    • and Albert de la Chapelle
    PNAS 2017 114 (3) 474-479; published ahead of print January 3, 2017, doi:10.1073/pnas.1619917114

  • Identification of NAD+ capped mRNAs in Saccharomyces cerevisiae

    • Robert W. Walters,
    • Tyler Matheny,
    • Laura S. Mizoue,
    • Bhalchandra S. Rao,
    • Denise Muhlrad,
    • and Roy Parker
    PNAS 2017 114 (3) 480-485; published ahead of print December 28, 2016, doi:10.1073/pnas.1619369114
    OPEN ACCESS ARTICLE

  • Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4

    • Irina F. Sevrioukova and
    • Thomas L. Poulos
    PNAS 2017 114 (3) 486-491; published ahead of print December 28, 2016, doi:10.1073/pnas.1616198114

Cell Biology

  • SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes

    • Anne Norris,
    • Prasad Tammineni,
    • Simon Wang,
    • Julianne Gerdes,
    • Alexandra Murr,
    • Kelvin Y. Kwan,
    • Qian Cai,
    • and Barth D. Grant
    PNAS 2017 114 (3) E307-E316; published ahead of print January 4, 2017, doi:10.1073/pnas.1612730114

  • Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling

    • Andrew M. Kidger,
    • Linda K. Rushworth,
    • Julia Stellzig,
    • Jane Davidson,
    • Christopher J. Bryant,
    • Cassidy Bayley,
    • Edward Caddye,
    • Tim Rogers,
    • Stephen M. Keyse,
    • and Christopher J. Caunt
    PNAS 2017 114 (3) E317-E326; published ahead of print January 4, 2017, doi:10.1073/pnas.1614684114
    OPEN ACCESS ARTICLE

  • Matrix stiffening promotes a tumor vasculature phenotype

    • Francois Bordeleau,
    • Brooke N. Mason,
    • Emmanuel Macklin Lollis,
    • Michael Mazzola,
    • Matthew R. Zanotelli,
    • Sahana Somasegar,
    • Joseph P. Califano,
    • Christine Montague,
    • Danielle J. LaValley,
    • John Huynh,
    • Nuria Mencia-Trinchant,
    • Yashira L. Negrón Abril,
    • Duane C. Hassane,
    • Lawrence J. Bonassar,
    • Jonathan T. Butcher,
    • Robert S. Weiss,
    • and Cynthia A. Reinhart-King
    PNAS 2017 114 (3) 492-497; published ahead of print December 29, 2016, doi:10.1073/pnas.1613855114
    OPEN ACCESS ARTICLE

  • p53 pathway is involved in cell competition during mouse embryogenesis

    • Guoxin Zhang,
    • Yinyin Xie,
    • Ying Zhou,
    • Cong Xiang,
    • Lai Chen,
    • Chenxi Zhang,
    • Xiaoshuang Hou,
    • Jiong Chen,
    • Hui Zong,
    • and Geng Liu
    PNAS 2017 114 (3) 498-503; published ahead of print January 3, 2017, doi:10.1073/pnas.1617414114

  • TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation

    • Carlos R. Reis,
    • Ping-Hung Chen,
    • Nawal Bendris,
    • and Sandra L. Schmid
    PNAS 2017 114 (3) 504-509; published ahead of print January 3, 2017, doi:10.1073/pnas.1615072114

Developmental Biology

  • In vivo severity ranking of Ras pathway mutations associated with developmental disorders

    • Granton A. Jindal,
    • Yogesh Goyal,
    • Kei Yamaya,
    • Alan S. Futran,
    • Iason Kountouridis,
    • Courtney A. Balgobin,
    • Trudi Schüpbach,
    • Rebecca D. Burdine,
    • and Stanislav Y. Shvartsman
    PNAS 2017 114 (3) 510-515; published ahead of print January 3, 2017, doi:10.1073/pnas.1615651114

  • Adenylate cyclase A acting on PKA mediates induction of stalk formation by cyclic diguanylate at the Dictyostelium organizer

    • Zhi-Hui Chen,
    • Reema Singh,
    • Christian Cole,
    • Hajara Mohammed Lawal,
    • Christina Schilde,
    • Melanie Febrer,
    • Geoffrey J. Barton,
    • and Pauline Schaap
    PNAS 2017 114 (3) 516-521; published ahead of print January 5, 2017, doi:10.1073/pnas.1608393114
    OPEN ACCESS ARTICLE

Ecology

  • Ancient human disturbances may be skewing our understanding of Amazonian forests

    • Crystal N. H. McMichael,
    • Frazer Matthews-Bird,
    • William Farfan-Rios,
    • and Kenneth J. Feeley
    PNAS 2017 114 (3) 522-527; published ahead of print January 3, 2017, doi:10.1073/pnas.1614577114

  • The global decline of cheetah Acinonyx jubatus and what it means for conservation

    • Sarah M. Durant,
    • Nicholas Mitchell,
    • Rosemary Groom,
    • Nathalie Pettorelli,
    • Audrey Ipavec,
    • Andrew P. Jacobson,
    • Rosie Woodroffe,
    • Monika Böhm,
    • Luke T. B. Hunter,
    • Matthew S. Becker,
    • Femke Broekhuis,
    • Sultana Bashir,
    • Leah Andresen,
    • Ortwin Aschenborn,
    • Mohammed Beddiaf,
    • Farid Belbachir,
    • Amel Belbachir-Bazi,
    • Ali Berbash,
    • Iracelma Brandao de Matos Machado,
    • Christine Breitenmoser,
    • Monica Chege,
    • Deon Cilliers,
    • Harriet Davies-Mostert,
    • Amy J. Dickman,
    • Fabiano Ezekiel,
    • Mohammad S. Farhadinia,
    • Paul Funston,
    • Philipp Henschel,
    • Jane Horgan,
    • Hans H. de Iongh,
    • Houman Jowkar,
    • Rebecca Klein,
    • Peter Andrew Lindsey,
    • Laurie Marker,
    • Kelly Marnewick,
    • Joerg Melzheimer,
    • Johnathan Merkle,
    • Jassiel M'soka,
    • Maurus Msuha,
    • Helen O'Neill,
    • Megan Parker,
    • Gianetta Purchase,
    • Samaila Sahailou,
    • Yohanna Saidu,
    • Abdoulkarim Samna,
    • Anne Schmidt-Küntzel,
    • Eda Selebatso,
    • Etotépé A. Sogbohossou,
    • Alaaeldin Soultan,
    • Emma Stone,
    • Esther van der Meer,
    • Rudie van Vuuren,
    • Mary Wykstra,
    • and Kim Young-Overton
    PNAS 2017 114 (3) 528-533; published ahead of print December 27, 2016, doi:10.1073/pnas.1611122114
    See Commentary on page 430 in issue 3 of volume 114

Evolution

  • Higher rates of sex evolve during adaptation to more complex environments

    • Pepijn Luijckx,
    • Eddie Ka Ho Ho,
    • Majid Gasim,
    • Suyang Chen,
    • Andrijana Stanic,
    • Connor Yanchus,
    • Yun Seong Kim,
    • and Aneil F. Agrawal
    PNAS 2017 114 (3) 534-539; published ahead of print January 4, 2017, doi:10.1073/pnas.1604072114

  • Dinosaur incubation periods directly determined from growth-line counts in embryonic teeth show reptilian-grade development

    • Gregory M. Erickson,
    • Darla K. Zelenitsky,
    • David Ian Kay,
    • and Mark A. Norell
    PNAS 2017 114 (3) 540-545; published ahead of print January 3, 2017, doi:10.1073/pnas.1613716114
    OPEN ACCESS ARTICLE

  • Antibiotic stress selects against cooperation in the pathogenic bacterium Pseudomonas aeruginosa

    • Marie Vasse,
    • Robert J. Noble,
    • Andrei R. Akhmetzhanov,
    • Clara Torres-Barceló,
    • James Gurney,
    • Simon Benateau,
    • Claire Gougat-Barbera,
    • Oliver Kaltz,
    • and Michael E. Hochberg
    PNAS 2017 114 (3) 546-551; published ahead of print January 3, 2017, doi:10.1073/pnas.1612522114
    OPEN ACCESS ARTICLE

Genetics

  • Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

    • Michael H. Guo,
    • Satish K. Nandakumar,
    • Jacob C. Ulirsch,
    • Seyedeh M. Zekavat,
    • Jason D. Buenrostro,
    • Pradeep Natarajan,
    • Rany M. Salem,
    • Roberto Chiarle,
    • Mario Mitt,
    • Mart Kals,
    • Kalle Pärn,
    • Krista Fischer,
    • Lili Milani,
    • Reedik Mägi,
    • Priit Palta,
    • Stacey B. Gabriel,
    • Andres Metspalu,
    • Eric S. Lander,
    • Sekar Kathiresan,
    • Joel N. Hirschhorn,
    • Tõnu Esko,
    • and Vijay G. Sankaran
    PNAS 2017 114 (3) E327-E336; published ahead of print December 28, 2016, doi:10.1073/pnas.1619052114
    OPEN ACCESS ARTICLE

  • SIR2 suppresses replication gaps and genome instability by balancing replication between repetitive and unique sequences

    • Eric J. Foss,
    • Uyen Lao,
    • Emily Dalrymple,
    • Robin L. Adrianse,
    • Taylor Loe,
    • and Antonio Bedalov
    PNAS 2017 114 (3) 552-557; published ahead of print January 3, 2017, doi:10.1073/pnas.1614781114

  • ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations

    • Amity R. Roberts,
    • Louise H. Appleton,
    • Adrian Cortes,
    • Matteo Vecellio,
    • Jonathan Lau,
    • Laura Watts,
    • Matthew A. Brown,
    • and Paul Wordsworth
    PNAS 2017 114 (3) 558-561; published ahead of print January 3, 2017, doi:10.1073/pnas.1618856114
    OPEN ACCESS ARTICLE

Immunology and Inflammation

  • GAS6 is a key homeostatic immunological regulator of host–commensal interactions in the oral mucosa

    • Maria Nassar,
    • Yaara Tabib,
    • Tal Capucha,
    • Gabriel Mizraji,
    • Tsipora Nir,
    • Meirav Pevsner-Fischer,
    • Gili Zilberman-Schapira,
    • Oded Heyman,
    • Gabriel Nussbaum,
    • Herve Bercovier,
    • Asaf Wilensky,
    • Eran Elinav,
    • Tal Burstyn-Cohen,
    • and Avi-Hai Hovav
    PNAS 2017 114 (3) E337-E346; published ahead of print January 3, 2017, doi:10.1073/pnas.1614926114

  • CD74 is a novel transcription regulator

    • Naama Gil-Yarom,
    • Lihi Radomir,
    • Lital Sever,
    • Matthias P. Kramer,
    • Hadas Lewinsky,
    • Chamutal Bornstein,
    • Ronnie Blecher-Gonen,
    • Zohar Barnett-Itzhaki,
    • Vita Mirkin,
    • Gilgi Friedlander,
    • Lev Shvidel,
    • Yair Herishanu,
    • Elias J. Lolis,
    • Shirly Becker-Herman,
    • Ido Amit,
    • and Idit Shachar
    PNAS 2017 114 (3) 562-567; published ahead of print December 28, 2016, doi:10.1073/pnas.1612195114

  • Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia

    • Jay R. Thiagarajah,
    • Jeffrey Chang,
    • Jeremy A. Goettel,
    • Alan S. Verkman,
    • and Wayne I. Lencer
    PNAS 2017 114 (3) 568-573; published ahead of print January 3, 2017, doi:10.1073/pnas.1612921114

  • Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation

    • William A. McEwan,
    • Benjamin Falcon,
    • Marina Vaysburd,
    • Dean Clift,
    • Adrian L. Oblak,
    • Bernardino Ghetti,
    • Michel Goedert,
    • and Leo C. James
    PNAS 2017 114 (3) 574-579; published ahead of print January 3, 2017, doi:10.1073/pnas.1607215114

  • Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

    • Peiwen Chen,
    • Hao Zuo,
    • Hu Xiong,
    • Matthew J. Kolar,
    • Qian Chu,
    • Alan Saghatelian,
    • Daniel J. Siegwart,
    • and Yihong Wan
    PNAS 2017 114 (3) 580-585; published ahead of print January 3, 2017, doi:10.1073/pnas.1614035114

Medical Sciences

  • Imaging individual neurons in the retinal ganglion cell layer of the living eye

    • Ethan A. Rossi,
    • Charles E. Granger,
    • Robin Sharma,
    • Qiang Yang,
    • Kenichi Saito,
    • Christina Schwarz,
    • Sarah Walters,
    • Koji Nozato,
    • Jie Zhang,
    • Tomoaki Kawakami,
    • William Fischer,
    • Lisa R. Latchney,
    • Jennifer J. Hunter,
    • Mina M. Chung,
    • and David R. Williams
    PNAS 2017 114 (3) 586-591; published ahead of print January 3, 2017, doi:10.1073/pnas.1613445114
    OPEN ACCESS ARTICLE

  • Speedy A–Cdk2 binding mediates initial telomere–nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation

    • Zhaowei Tu,
    • Mustafa Bilal Bayazit,
    • Hongbin Liu,
    • Jingjing Zhang,
    • Kiran Busayavalasa,
    • Sanjiv Risal,
    • Jingchen Shao,
    • Ande Satyanarayana,
    • Vincenzo Coppola,
    • Lino Tessarollo,
    • Meenakshi Singh,
    • Chunwei Zheng,
    • Chunsheng Han,
    • Zijiang Chen,
    • Philipp Kaldis,
    • Jan-Åke Gustafsson,
    • and Kui Liu
    PNAS 2017 114 (3) 592-597; published ahead of print December 28, 2016, doi:10.1073/pnas.1618465114

Microbiology

  • Cell morphology drives spatial patterning in microbial communities

    • William P. J. Smith,
    • Yohan Davit,
    • James M. Osborne,
    • Wook Kim,
    • Kevin R. Foster,
    • and Joe M. Pitt-Francis
    PNAS 2017 114 (3) E280-E286; published ahead of print December 30, 2016, doi:10.1073/pnas.1613007114

  • Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges

    • Gerald Lackner,
    • Eike Edzard Peters,
    • Eric J. N. Helfrich,
    • and Jörn Piel
    PNAS 2017 114 (3) E347-E356; published ahead of print January 3, 2017, doi:10.1073/pnas.1616234114

  • Diverse evolutionary patterns of pneumococcal antigens identified by pangenome-wide immunological screening

    • Nicholas J. Croucher,
    • Joseph J. Campo,
    • Timothy Q. Le,
    • Xiaowu Liang,
    • Stephen D. Bentley,
    • William P. Hanage,
    • and Marc Lipsitch
    PNAS 2017 114 (3) E357-E366; published ahead of print January 4, 2017, doi:10.1073/pnas.1613937114

  • Impact of short-chain galactooligosaccharides on the gut microbiome of lactose-intolerant individuals

    • M. Andrea Azcarate-Peril,
    • Andrew J. Ritter,
    • Dennis Savaiano,
    • Andrea Monteagudo-Mera,
    • Carlton Anderson,
    • Scott T. Magness,
    • and Todd R. Klaenhammer
    PNAS 2017 114 (3) E367-E375; published ahead of print January 3, 2017, doi:10.1073/pnas.1606722113
    OPEN ACCESS ARTICLE

  • Characterization of cytopathic factors through genome-wide analysis of the Zika viral proteins in fission yeast

    • Ge Li,
    • Melissa Poulsen,
    • Csaba Fenyvuesvolgyi,
    • Yoko Yashiroda,
    • Minoru Yoshida,
    • J. Marc Simard,
    • Robert C. Gallo,
    • and Richard Y. Zhao
    PNAS 2017 114 (3) E376-E385; published ahead of print January 3, 2017, doi:10.1073/pnas.1619735114
    OPEN ACCESS ARTICLE

  • Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure

    • Cyril Le Nouën,
    • Thomas McCarty,
    • Michael Brown,
    • Melissa Laird Smith,
    • Roberto Lleras,
    • Michael A. Dolan,
    • Masfique Mehedi,
    • Lijuan Yang,
    • Cindy Luongo,
    • Bo Liang,
    • Shirin Munir,
    • Joshua M. DiNapoli,
    • Steffen Mueller,
    • Eckard Wimmer,
    • Peter L. Collins,
    • and Ursula J. Buchholz
    PNAS 2017 114 (3) E386-E395; published ahead of print January 3, 2017, doi:10.1073/pnas.1619242114
    OPEN ACCESS ARTICLE

  • Cryo-EM study of slow bee paralysis virus at low pH reveals iflavirus genome release mechanism

    • Sergei Kalynych,
    • Tibor Füzik,
    • Antonín Přidal,
    • Joachim de Miranda,
    • and Pavel Plevka
    PNAS 2017 114 (3) 598-603; published ahead of print January 4, 2017, doi:10.1073/pnas.1616562114
    OPEN ACCESS ARTICLE

Neuroscience

  • Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity

    • Minshu Li,
    • Zhiguo Li,
    • Yang Yao,
    • Wei-Na Jin,
    • Kristofer Wood,
    • Qiang Liu,
    • Fu-Dong Shi,
    • and Junwei Hao
    PNAS 2017 114 (3) E396-E405; published ahead of print December 19, 2016, doi:10.1073/pnas.1612930114
    OPEN ACCESS ARTICLE
    See Commentary on page 425 in issue 3 of volume 114

  • REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation–differentiation balance in the developing brain

    • Caitlin E. Monaghan,
    • Tamilla Nechiporuk,
    • Sophia Jeng,
    • Shannon K. McWeeney,
    • Jianxun Wang,
    • Michael G. Rosenfeld,
    • and Gail Mandel
    PNAS 2017 114 (3) E406-E415; published ahead of print January 3, 2017, doi:10.1073/pnas.1620230114

  • Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys

    • Takamichi Tohyama,
    • Masaharu Kinoshita,
    • Kenta Kobayashi,
    • Kaoru Isa,
    • Dai Watanabe,
    • Kazuto Kobayashi,
    • Meigen Liu,
    • and Tadashi Isa
    PNAS 2017 114 (3) 604-609; published ahead of print January 3, 2017, doi:10.1073/pnas.1610787114

Physiology

  • Stochastic initiation and termination of calcium-mediated triggered activity in cardiac myocytes

    • Zhen Song,
    • Zhilin Qu,
    • and Alain Karma
    PNAS 2017 114 (3) E270-E279; published ahead of print January 3, 2017, doi:10.1073/pnas.1614051114
    OPEN ACCESS ARTICLE

  • Tbx20 controls the expression of the KCNH2 gene and of hERG channels

    • Ricardo Caballero,
    • Raquel G. Utrilla,
    • Irene Amorós,
    • Marcos Matamoros,
    • Marta Pérez-Hernández,
    • David Tinaquero,
    • Silvia Alfayate,
    • Paloma Nieto-Marín,
    • Guadalupe Guerrero-Serna,
    • Qing-hua Liu,
    • Roberto Ramos-Mondragón,
    • Daniela Ponce-Balbuena,
    • Todd Herron,
    • Katherine F. Campbell,
    • David Filgueiras-Rama,
    • Rafael Peinado,
    • José L. López-Sendón,
    • José Jalife,
    • Eva Delpón,
    • and Juan Tamargo
    PNAS 2017 114 (3) E416-E425; published ahead of print January 3, 2017, doi:10.1073/pnas.1612383114

Plant Biology

  • ATG9 regulates autophagosome progression from the endoplasmic reticulum in Arabidopsis

    • Xiaohong Zhuang,
    • Kin Pan Chung,
    • Yong Cui,
    • Weili Lin,
    • Caiji Gao,
    • Byung-Ho Kang,
    • and Liwen Jiang
    PNAS 2017 114 (3) E426-E435; published ahead of print January 4, 2017, doi:10.1073/pnas.1616299114

Corrections (Online Only)

  • Correction for Novack-Gottshall, Love, not war, drove the Mesozoic marine revolution

    PNAS 2017 114 (3) E436; published ahead of print January 9, 2017, doi:10.1073/pnas.1620620114

  • Correction for Lin et al., DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure

    PNAS 2017 114 (3) E437; published ahead of print January 9, 2017, doi:10.1073/pnas.1620381114