Why We're Different
[6.29.16]
What we're trying to do in behavioral genetics and medical genetics is explain differences. It's important to know that we all share approximately 99 percent of our DNA sequence. If we sequence, as we can now readily do, all of our 3 billion base pairs of DNA, we will be the same at over 99 percent of all those bases. That's what makes us similar to each other. It makes us similar to chimps and most mammals. We're over 90 percent similar to all mammals. There's a lot of genetic similarity that's important from an evolutionary perspective, but it can't explain why we're different. That's what we're up to, trying to explain why some children are reading disabled, or some people become schizophrenic, or why some people suffer from alcoholism, et cetera. We're always talking about differences. The only genetics that makes a difference is that 1 percent of the 3 billion base pairs. But that is over 10 million base pairs of DNA. We're looking at these differences and asking to what extent they cause the differences that we observe.
ROBERT PLOMIN is a professor of behavioral genetics at King's College London and deputy director of the Social, Genetic and Developmental Psychiatry Centre at the Institute of Psychiatry, Psychology and Neuroscience. Robert Plomin's Edge Bio Page
Deontology Or Trustworthiness?
[6.16.16]
DANIEL KAHNEMAN: The benefit that people get from taking a deontological position is that they look more trustworthy. Let's look at the other side of this. If I take a consequentialist position, it means that you can't trust me because, under some circumstances, I might decide to break the rule in my interaction with you. I was puzzled when I was looking at this. What is the essence of what is going on here? Is it deontology or trustworthiness? It doesn't seem to be the same to say we are wired to like people who take a deontological position, or we are wired to like people who are trustworthy. Which of these two is it?
MOLLY CROCKETT: What the work suggests is that we infer how trustworthy someone is going to be by observing the kinds of judgments and decisions that they make. If I'm interacting with you, I can't get inside your head. I don't know what your utility function looks like. But I can infer what that utility function is by the things that you say and do.
This is one of the most important things that we do as humans. I've become increasingly interested in how we build mental models of other people's preferences and beliefs and how we make inferences about what those are, based on observables. We infer how trustworthy someone is going to be based on their condemnation of wrongdoing and their advocating a hard-and-fast morality over one that's more flexible.
MOLLY CROCKETT is an associate professor of experimental psychology, fellow of Jesus College, and distinguished research fellow at the Oxford Centre for Neuroethics, University of Oxford. Molly Crockett's Edge Bio Page
DANIEL KAHNEMAN is the recipient of the Nobel Prize in Economics (2002), and the Presidential Medal of Freedom (2013). He is the Eugene Higgins Professor of Psychology Emeritus, Princeton, and author of Thinking, Fast and Slow. Daniel Kahneman's Edge Bio Page
Misunderstanding Positive Emotion
[5.25.16]
We know that in the physical ecosystem biodiversity is healthy and important. People can buy into that. We know that biodiversity fosters resistance to pathogens and invasive species. When you explain to someone that the human mind may not be so different, that it's important to have a diverse array of emotions—joy, sadness, love, admiration, guilt—and that these are all important pieces of our internal human emotional ecosystem, people can understand that. People appreciate that diversity is important, that maybe it's some sort of spice of mental life.
When you frame it that way, people are more readily able to not put such a premium on positive emotions and, in some situations, try to foster other kinds of experiences if they think it's part of a more diverse psychological life and repertoire. Framing it less as pushing positive emotions down, but as letting all emotions grow and thrive. They're all important sources of information for us and we have them for a reason. We have evolutionary goals; people can understand that. That's one way we've been thinking about trying to frame this. You don't just want to grow one kind of plant in your garden, you want to have a diverse array.
JUNE GRUBER is an assistant professor of psychology at the University of Colorado, Boulder, and director of the Positive Emotion and Psychopathology Laboratory. June Gruber's Edge Bio Page
THE REALITY CLUB: Robert Provine
The Social Construction of Stories
How Narratives Can Get in the Way of Being Happier [5.13.16]
I went for dinner with a friend who spent the whole of the evening complaining about her job, her boss, her colleagues, and her commute. Everything about her day-to-day experiences was miserable. Then, at the end of dinner, she said, "I love where I work." That's quite common. She was working for an organization where she'd always wanted to work, her parents were proud, her friends were jealous. How could she not be happy when she thought about the story of how happy she was where she was working? Her experiences—day-to-day and moment-to-moment—were telling her something quite different.
I'm interested in where these narratives come from, particularly those narratives that sometimes get in the way of us being happier. There's been a lot of psychological research on how stories are helpful for us; for example, in the case of experiencing adversity or trauma. If we look for explanation and reason through narrative, it helps us cope with the adverse consequences. There's been a lot of work on that. I'm interested more in the social constructions of the stories, in the things that evolution, society, our parents, or historical accident tell us about the lives that we ought to be leading, and in particular, how they might sometimes get in the way of us experiencing better lives.
PAUL DOLAN is a professor of behavioral science at the London School of Economics and Political Science and author of Happiness by Design. Paul Dolan's Edge Bio Page
THE REALITY CLUB: Elaine Pagels
Is Big Data Taking Us Closer to the Deeper Questions in Artificial Intelligence?
[5.4.16]
What we need to do in artificial intelligence is turn back to psychology. Brute force is great; we're using it in a lot of ways, like speech recognition, license plate recognition, and for categorization, but there are still some things that people do a lot better. We should be studying human beings to understand how they do it better.
People are still much better at understanding sentences, paragraphs, books, and discourse where there's connected prose. It's one thing to do a keyword search. You can find any sentence you want that's out there on the web by just having the right keywords, but if you want a system that could summarize an article for you in a way that you trust, we're nowhere near that. The closest thing we have to that might be Google Translate, which can translate your news story into another language, but not at a level that you trust. Again, trust is a big part of it. You would never put a legal document into Google Translate and think that the answer is correct.
GARY MARCUS is CEO and founder, Geometric Intelligence; professor of psychology, New York University; author, Guitar Zero: The New Musician and the Science of Learning. Gary Marcus's Edge Bio Page
A Characteristic Difference
When Experimental Philosophy Meets Psychology [4.26.16]
DANIEL KAHNEMAN: We're at the nub of the question. You come from philosophy, so there are certain things that are of interest to you. You want to convey two things at once: that the question is exciting, and that you have something new to say about it. It is true that I, as a psychologist, would come to the same question and conclude that it's an impossible question. Those are two impossible questions, and I certainly would not expect people to answer them in any way that is coherent.
My first assumption, coming to it as a psychologist, is that there is no coherence. You agree with me that there is no coherence. What makes it exciting from the point of view of philosophy is that there is no coherence. Whereas, as a psychologist, I take it for granted that there is no coherence, so it's less exciting. That could be one of the differences.
JOSHUA KNOBE: That's really helpful. The thing we showed is not just that it is incoherent but along which dimension it is incoherent. It seems like there was evidence already that there's something pulling us towards one side and something pulling us to the other side, and we want to know which thing is pulling us towards one side or the other. We suggested that it's this difference between abstract thinking and concrete thinking....
JOSHUA KNOBE is an experimental philosopher and professor of philosophy and cognitive science at Yale University. Joshua Knobe's Edge Bio Page
DANIEL KAHNEMAN is the recipient of the Nobel Prize in Economics (2002), and the Presidential Medal of Freedom (2013). He is the Eugene Higgins Professor of Psychology Emeritus, Princeton, and author of Thinking Fast and Slow. Daniel Kahneman's Edge Bio Page
Power Over Nature
New Phenomena That Will Change and Enrich Our Understanding of Fundamentals [4.20.16]
The big story of the 20th and the 21st century is that we’re learning to control the world better. With the development of quantum mechanics, we understand the fundamental principles of what matter is and how it behaves that’s adequate for all engineering purposes.
The limitation is just our imagination and our ability to calculate the consequences of the laws. We’re getting better at both of those as we gain experience. We have more imagination. As computing develops, we learn how to calculate the consequences of the laws better and better. There’s also a feedback cycle: when you understand matter better, you can design better computers, which will enable you to calculate better. It's kind of an ascending helix.
FRANK WILCZEK, currently the Herman Feshbach Professor of Physics at MIT, has received many prizes for his work in physics, including the Nobel Prize (2004) for work he did as a graduate student at Princeton University. Frank Wilczek's Edge Bio Page
LIFE (On Sale Now!)
The "Best of Edge" Book Series [3.14.16]
CONTENTS: Evolvability Richard Dawkins Genomic Imprinting David Haig A Full-Force Storm with Gale Winds Blowing Robert Trivers What Evolution Is Ernst Mayr Genetics Plus Time Steve Jones A United Biology E. O. Wilson Is Life Analog or Digital? Freeman Dyson Life: What a Concept! Freeman Dyson, J. Craig Venter, George Church, Dimitar Sasselov, Seth Lloyd, Robert Shapiro The Gene-Centric View: A Conversation Richard Dawkins, J. Craig Venter The Nature of Normal Human Variety Armand Marie Leroi Brains Plus Brawn Daniel Lieberman Mapping the Neanderthal Genome Svante Pääbo On Biocomputation J. Craig Venter, Ray Kurzweil, Rodney Brooks Engineering Biology Drew Endy Eat Me Before I Eat You: A New Foe for Bad Bugs Kary Mullis Duck Sex and Aesthetic Evolution Richard Prum Toxo Robert Sapolsky The Adjacent Possible Stuart Kauffman (with an introduction by John Brockman)
The Augmented Human Being
[3.30.16]
There are now 2000 gene therapies where you’ll take a little piece of engineered DNA, put it inside of a viral coat so all the viral genes are gone, and you can put in, say, a human gene or you can have nonviral delivery, but the important thing is that you’re delivering it either inside of the human or you’re taking cells out of the human and putting the DNA in and then putting them back in. But you can do very powerful things like curing inherited diseases, curing infectious diseases.
For example, you can edit out the receptor for the HIV virus and cure AIDS patients in a way that's not dependent upon vaccines and multidrug resistance, which has plagued the HIV AIDS story from the very beginning. You’re basically making a human being which is now augmented in a certain sense so that, unlike most humans, they are resistant to this major plague of mankind—HIV AIDS.
There are now people walking around who are genetically modified: There are some that are resistant to AIDS because they have had their T cells, or more generally, their blood cells modified. There are children that have been cured of blindness by gene therapy. None of this is CRISPR, but it’s in the same vein. CRISPR is overtaking it very quickly and it’s drafting behind all the beautiful work that’s been done with delivery of DNA, delivery of genetic components to patients.
GEORGE CHURCH is a professor of genetics at Harvard Medical School and director of the Personal Genome Project. George Church's Edge Bio Page
Forming the Minds That Will Make the Future
The Reality Club Conversation Continues [3.30.16]
[ Editor's Note: On March 9, 2016, Edge published a conversation with Howard Gardner called "Liberal Arts and Sciences in the 21st Century." The reaction from The Reality Club was immediate, strong, and engaging, with responses from Douglas Rushkoff, Patricia Churchland, Mark Pagel, Roger Schank, Neil Gershenfeld, Cristine Legare, and David Myers. Now, Gardner responds. . . . ]
Just as readers of Edge base our thoughts about higher education significantly on our own experiences, we also draw on our own more recent experiences as teachers—formal or informal—as scholars, and as human beings who continue to learn, engage, enjoy, and debate. There is no one best or one right way to engage in liberal arts learning: some benefit more from reading and writing, some from debating, some from lectures or Socratic seminars, some from travel and reflection, some from carrying out projects or tackling overwhelming challenges or creating works of art. Indeed, in my ideal school students would be exposed to several different pedagogical philosophies and practices. Not only would they benefit from this diversity, students would also have the chance to determine what works best for them and how they might optimally share with others what they’ve learned and what they can do.
HOWARD GARDNER is the John H. and Elisabeth A. Hobbs Professor of Cognition and Education at the Harvard Graduate School of Education. Gardner also directs the Good Project. Howard Gardner's Edge Bio Page
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