TOXICOLOGICAL PROFILE FOR
BENZOTHIAZOLE
Criteria and Standards Division
Office of Drinking Water
U.S. Environmental Protection Agency
Washington, DC 20460
June 1989
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TOXICOLOGICAL PROFILE
FOR
BENZOTHIAZOLE
June 1989
Criteria and Standards Division
Office of Drinking Water
U.S. Environmental Protection Agency
Washington, DC 20460
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BENZOTHIAZOLE
A. GENERAL
1. CAS Number: 95-16-9
2. RTECS Number: DL0875000
3. General Name/Svnonvms: Benzosulfanazole
l-Thia-3-azaindene
4. Molecular Formula-: C7H5NS
5. Molecular Weight: 135.18
6. Structure:
B. PHYSICAL AND CHEMICAL PROPERTIES
1. State: Yellow liquid with unpleasant odor.
2. Vapor Pressure: No information was found.
3. Melting Point: 2.0°C
4. Boilino Point: 227-228°C at 765 mmHg
and 131°C at 34 mmHg
5. Specific Gravity; 1.246
6. Solubility: Slightly soluble in water;
freely soluble in alchohol
and carbon disulfide. Soluble
in ether, acetone, and benzene.
Sax and Lewis (1987)
Weast (1988)
Windholz et al.
(1983)
Sax and Lewis (1987)
Windholz (1983);
Weast (1988)
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7. Log Kn.n.: No information was found.
8. UV Absorption: No information was found.
C. PHYSICAL/CHEMICAL EQUILIBRIUM FACTORS
1. Bioconcentration Factors (BCR: No information was found.
2. Kwa: No information was found.
3. !<„: No information was found.
D. ENVIRONMENTAL FATE
1. Photolysis: No information was found.
2. Leaching: No information was found.
3. Route of Water Contamination: No information was found.
4. Hydrolysis: No information was found.
5. Plant Uptake: No information was found.
6. Microbial Degradation: No information was found.
7. Persistence in Soil/Water: No information was found.
8. Byproducts: No information was found.
9. Vaporization: No information was found.
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E. ACUTE TOXICITY IN MAMMALS
Animal/strain/sex Route
(mg/kg)
Effects
Reference
Rat/F344/M Oral
F Oral
493
466
i
OJ
Antemortem observations included
lethargy; ataxia; prostration;
lacrimation; squinting; body
cool to touch; loose, few, or no
stools; crusty eye/muzzle; and
yellow/brown stained or damp fur
in the peri anal region.
Necropsy of animals found dead
revealed dark contents of
stomach and small intestine;
multiple focal, black
discolorations of glandular
stomachs; diffuse, pale
discoloration of livers; diffuse,
pale, or red discoloration of lungs;
and a distended urinary bladder.
Necropsy of terminal sacrifice
animals revealed enlarged, dark
red spleens; an ovarian cyst; a
diaphragmatic hernia; and small
testes.
Mayhew and Muni (1986)
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F. SKIN AND EYE IRRITATION AND SENSITIZATION IN MAMMALS
No information was found.
G. SUBCHRONIC TOXICITY IN MAMMALS
No information was found.
H. REPRODUCTIVE EFFECTS AND TERATOGENICITY IN MAMMALS
No information was found.
I. MUTAGENICITY/GENOTOXICITY
Data are presented in tabular form on page 5.
J., CHRONIC/CARCINOGEN1CITY STUDIES IN MAMMALS
No information was found.
K. PHARMACOKINETICS IN MAMMALS
No information was found.
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I. MUTAGENICITY/GENOTOXICITY
Test
Strain
Activation
Dose/concent ra t i on
Toxic effects
Reference
Ames mutagenicity
assay
Salmonella
typhimurium
TA 98, TA 100,
TA 1535,
TA 1537,
TA 1538.
S9
1, 0.2, 0.04,
0.008, 0.0016,
0.00032, pL/plate
Benzothiazole
was not
mutagenic
with and without
metabolic
activation.
Sano and Korte (1985)
I
en
I
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L. HUMAN HEALTH EFFECTS
No information was found.
M. EXISTING STANDARDS/CRITERIA
No information was found.
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N. REFERENCES
Mayhew DA, Muni IA. 1986. Dermal, Eye, and Oral Toxicological Evaluations.
Phase II. Acute Oral LD50 Determinations of Benzothiazole, Diathiane, and
Oxathiane. Fort Detrick, MD: U.S. Army Medical Research and Development
Command. Available from DTIC. AD-A172647.
Sano S, Korte D. 1985. Mutagenic Potential of Benzothiazole. Fort Detrick,
MD: U.S. Army Medical Research and Development Command. Report No. 205.
Available from DTIC. AD-A164696.
Sax NI, Lewis RJ. 1987. Hawley's Condensed Chemical Dictionary, llth Ed.
New York, NY: Van Nostrand Reinhold Company.
Weast RC. 1988. CRC Handbook of Chemistry and Physics. 69th Ed. Boca
Raton, FL: CRC Press, Inc.
Windholz M, Budavari S, Blumetti RF, Otterbein ES, eds. 1983. The Merck
Index -- An Encyclopedia of Chemicals, Drugs, and Biologicals. 10th Ed.
Rahway, NJ: Merck and Company, Inc., p. 158.
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