TOXICOLOGICAL PROFILE FOR
1,4-OXATHIANE
Criteria and Standards Division
Office of Drinking Water
U.S. Environmental Protection Agency
Washington, DC 20460
June, 1989
-------
TOXICOLOGICAL PROFILE
FOR
1,4-OXATHIANE
June 1989
Criteria and Standards Division
Office of Drinking Water
U.S. Environmental Protection Agency
Washington, DC 20460
-------
1,4-OXATHIANE
A. GENERAL
1. CAS Number: 15980-15-1
2. RTECS Number:
3. General Name/Synonyms: 1,4-Thioxane
4. Molecular Formula: C4H8OS
5. Molecular Weight: 104.17
6. Structure:
O
B. PHYSICAL AND CHEMICAL PROPERTIES
1. State: Colorless liquid
2. Vaoor Pressure: No information was found.
3. Melting Point: No information was found.
4. Boiling Point: 147°C at 755 mmHg
5. Specific Gravity: 1.1174
6. Solubility; No information was found.
-1-
Mayhew and Muni (1986)
Weast (1988)
Weast (1988)
-------
7. Log Kn...: No information was found.
8. UV Absorption: No information was Found.
C. PHYSICAL/CHEMICAL EQUILIBRIUM FACTORS
1. Bioconcentration Factors (BCF): No information was found.
2. Kwa: No information was found.
3. K,,,.: No information was found.
D. ENVIRONMENTAL FATE
1. Photolysis: No information was found.
2. Leaching; No information was found.
3. Route of Water Contamination; No information was found.
4. Hydrolysis: No information was found.
5. Plant Uptake: No information was found.
6. Microbial Degradation: No information was found.
7. Persistence in Soil/Water: No information was found.
8. Byproducts: No information was found.
9. Vaporization: No information was found.
-2-
-------
E. ACUTE TOXICITY IN MAMMALS
Animal/strain/sex Route
LDM (mg/kg)
Effects
Reference
Rat/-a/- Oral
Rat/Fischer 344/F Oral
2830
3000
U)
I
Antemortem observations
Included coma,
polypnea, lacrimation,
dyspnea, lethargy,
ataxla, cyanosis,
squinting, paralysis,
eplstaxis, wheezing,
decreased body temperature,
piloerectlon, hunched
posture, and alopecia.
These abnormalities were
generally seen in all
groups on day 0 and day 1.
Except for alopecia, no
abnormal signs were seen
after day 3.
Necropsy of animals found
dead revealed discolored
(black, red, blue/purple, or
dark yellow) and gel or
liquid contents (black,
amber, yellow, dark orange,
dark red, or green/gray) of
the intestines of nearly all
animals; gaseous stomachs and
intestines; brown gel or
liquid contents of stomachs;
and distended and discolored
urinary bladders.
Smyth et al. (1951)
Mayhew and Muni (1986)
-------
E. ACUTE TOXICITY IN MAMMALS (continued)
Animal/strain/sex Route IDW (mg/kg) Effects Reference
Rat/ Necropsy of animals at
(cont.) terminal sacrifice revealed
no abnormalities.
Rat/Sherman/M-F Inhalation 4000 ppm/4h Carpenter et al. (1949)
*Data not provided.
-------
F. SKIN AND EYE IRRITATION AND SENSITIZATION IN MAMMALS
No Information was found.
G. SUBCHRONIC TOXICITY IN MAMMALS
No Informal ton was found.
H. REPRODUCTION AND TERATOGENICITY IN MAMMALS
No Information was found.
I. MUTAGENICITY/GENOTOXICITY
Data are presented In tabular form on page 5.
J. CHRONIC/CARCINOGENICITY STUDIES IN MAMMALS
No information was found.
K. PHARMACOKINETICS IN MAMMALS
No information was found.
L. HUMAN HEALTH EFFECTS
No information was found.
-5-
-------
M. EXISTING STANDARDS/CRITERIA
No Information was found.
-6-
-------
I. HUTAGENICITY/GENOTOXICITY
Test
Strain
Activation
Dose/concent rat i on
Toxic effects
Reference
Ames mutagenicity
assay
Salmonella
typhimuriun
TA98, TA100,
TA1535, TA1537.
TA1538
S9
5. 1. 0.2. 0.04,
0.008. 0.0016
Ml/plate
No mutagenicity
detected with or
without metabolic
activation.
Sano and Korte (1985)
-------
N. REFERENCES
Carpenter CP, Smyth HF, Pozzani UC. 1949. The assay of acute vapor toxicity
and the grading and interpretation of results on 96 chemical compounds. J.
Ind. Hyg. Toxicol. 31:343-346.
Mayhew DA, Muni IA. 1986. Dermal, Eye, and Oral lexicological Evaluations.
Phase II. Acute Oral LD50 Determinations of Benzothiazole, Diathiane, and
Oxathiane. Fort Detrick, MD: U.S. Army Medical Research and Development
Command. Available from DTK. AD-A172647.
Sano S, Korte D. 1985. Mutagenic Potential of 1,4-Thioxane. Fort Detrick,
MD: U.S. Army Research and Development Command. Institute Report No. 206.
Smyth HF, Carpenter CP, Weil CS. 1951. Rang-finding toxicity data: List IV.
Am. Med. Assoc. Arch. Ind. Hyg. Occup. Med. 4:119-122.
Weast RC. 1988. CRC Handbook of Chemistry and Physics. 69th Ed. Boca
Raton, FL: CRC Press, Inc.
-8-
------- |