NARMS in Action

Antibiotic resistance in other parts of the world affects treatment options in the United States. Two studies explore this link for Salmonella enterica resistant to quinolones, a class of antibiotics commonly used to treat Salmonella infections:

• The first study examined the global story of emerging and highly resistant Salmonella serotype Kentucky. Salmonella Kentucky’s resistance to antibiotics has been reported in patients from Europe, most of whom had traveled to Africa and the Middle East. Learn about ciprofloxacin-resistant Salmonella Kentucky causing illness among people in the United States who acquired infections while traveling.
• The second study used surveillance data to determine that Salmonella serotype Enteritidis infections resistant to quinolone antibiotics are associated with recent international travel. Learn how this analysis broadens our understanding of infection sources

It can be difficult to find the source of a foodborne outbreak, especially when the outbreak is caused by Salmonella serotype Typhimurium, which can contaminate many different kinds of foods. This study looked at the genes that code for antibiotic resistance in Typhimurium and the plasmids (structures inside some cells that carry and spread resistance genes) that carry them as clues to the sources of outbreaks.

The authors examined resistance plasmids found in Salmonella Typhimurium isolated from retail meat, food animals, and humans. They found one type of plasmid in chicken and a different one in beef, but both types of plasmids were found in Typhimurium causing human infections. This shows that the type of plasmid may provide clues into the source of human infections. Learn more about this study, which demonstrates how bacterial genetic testing can help disease detectives find the source of an outbreak and stop it in its tracks.