Rutgers University Regional Biocontainment Laboratory

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• Contact Information
• Animal Capabilities
• Animal Models
• Pathogens
• Imaging Capabilities
• Laboratory and Analytical Support
• cGLP or cGMP Capabilities
• Specialized Areas or Major Equipment Available

Contact Information

Director: David S. Perlin, Ph.D.
Email: perlinds@njms.rutgers.edu
Website: http://njms.rutgers.edu/research/rbl/index.cfm

Animal Capabilities, including species and containment level(s)

BSL3: Mice, rats, guinea pigs, hamsters, rabbits, ferrets

Animal Models, including species, disease, and delivery method

• Mouse, pneumonic plague, aerosol or intranasal Mouse, bubonic plague, subcutaneous
• Mouse, anthrax, aerosol or intranasal
• Mouse, rabbit, tuberculosis (MDR/XDR TB), aerosol or intranasal
• Mouse, tularemia, intranasal, intradermal
• Mouse, glanders, IP, intranasal
• Hamster, glanders, IP, intransal
• Mouse, avian flu, intranasal
• Mouse, West Nile, mosquito
• Mouse, influenza A, intranasal
• Mouse, Chikungunya virus, intradermal
• Guinea pig, Influenza A, intranasal
• Mouse, canine distemper model for MS, aerosol or intranasal
• Rat, MDR Gram negative and positive bactera, skin and soft tissue infections
• Ferret, flu, SARS

Pathogens

• ​Category A Select Agent clearance: Bacillus anthracis, Yersina pestis, Francisella tularensis, Burkholderia mallei, Burkholderia pseudomallei, Brucella abortus, Brucella melitensis, Botulinum neurotoxin-producing species of Clostridium, Venezuelan equine encephalitis virus, monkeypox virus, SARS, YFV, H5N1 flu (pending)
• ​Category C and other pathogens: MDR/XDR-Mycobacterium tuberculosis, dengue. Other pathogens: MSSA, MRSA, VISA, M. tuberculosis (drug sensitive), Aspergillus spp., Candida spp., HIV, Cryptococcus spp., Plasmodium spp., canine distemper virus, H1N1 influenza A, vaccinia virus, Streptococcus pneumoniae, varicella zoster virus, human cytomegalovirus

Imaging Capabilities

Perkin Elmer FMT 1500 in vivo Whole Animal Imager

Laboratory and Analytical Support

• Immunology services: BD Accuri C6 Flow Cytometer BD FACScalibur Nikon fluorescent microscope
• Pathology services: Available following fixation
• ​Microbiology services: Routine target organ burdens by agar culture and real-time PCR for genomic equivalents; 5 color Agilent Real-Time Spectrofluorometer; CLSI MIC testing for antibiotics

Ability To Accommodate cGLP or cGMP studies?

No.

Specialized Areas or Major Equipment Available

• Extensive aerosol infection models
• Rreal-time PCR (PCR/NASBA/Molecular Beacons) for nucleic acid diagnostics
• Vaccine challenge
• PK/PD studies of drugs in infected tissues using the ThermoScientific Orbitrap XL MALDI-Mass Spectrometer