The Systems Biology for Infectious Diseases Research Programs develop and validate predictive models of infectious disease initiation, progression, and outcomes.
These models are derived from the study of the architecture and dynamics of systems-wide host/pathogen molecular interaction networks during infection, using integrated datasets generated from a combination of “omics” technologies. The research findings will provide a deeper understanding of the overall complexity of the biological, biochemical, and biophysical molecular processes within microbial organisms as well as their interaction with the host.
The programs provide data and reagents that result from the research conducted and provide training for the broader infectious disease scientific community to promote the use of the systems biology approach.
Where Services Are Provided?
General infectious disease systems biology research is carried out by
- FluDyNeMo, New York University (Contact PI: Elodie Ghedin)
- Project description (NIH RePORTER)
- FluOMICS, Icahn School of Medicine at Mt. Sinai (Contact PI: Adolfo Garcia-Sastre) )
- Project description (NIH RePORTER)
- Omics4TB, Center for Infectious Disease Research (Contact PIs: Alan Aderem, David Sherman)
- Project description (NIH RePORTER)
- Omics-LHV, University of Wisconsin Madison (Contact PI: Yoshihiro Kawaoka)
- Project description (NIH RePORTER)
- The Malaria Host-Pathogen Interaction Center, Emory University
Systems biology studies work specific to antibacterial resistance is carried out by
- Baylor College of Medicine (Contact PI: Tor Savidge)
- Project description (NIH RePORTER)
- Boston College (Contact PI: Tim van Opijnen)
- Project description (NIH RePORTER)
- Los Angeles Biomedical Institute at Harbor-UCLA Med (Contact PI: Michael Yeaman)
- Project description (NIH RePORTER)
- University of Michigan (Contact PI: Vincent Young)
- Project description (NIH RePORTER)
- University of California San Diego (Contact PI: Bernhard Palsson)
- Project description (NIH RePORTER)
- Sloan-Kettering Institute for Cancer Research (Contact PI: Eric Pamer)
- Project description (NIH RePORTER)
Access
Data and software generated by Centers is being made available through publicly accessible Web and database sites, including the NIAID Bioinformatics Resource Centers.
Reagents are being made available through the program participants listed above.
Training in systems biology and “omics” technologies may be provided by the Centers. Please contact individual Centers for information regarding training opportunities.
Information and Related Resources
- News and Announcements
- Scientists seek a way to predict antibiotic resistance - November 2016
- Baylor and Texas Children’s receive $7.5 million NIH grant to combat common bacteria infection, antibiotic resistance – September 2016
- Scientists Receive $9.5M NIH Grant to Combat Antibiotic Resistance—April 2016
- Don’t let the bad bugs win: U-M team seeks to outsmart C. difficile with new $9.2 million effort—March 2016
- Recent Publications
- Quantifying influenza virus diversity and transmission in humans - FluDynemo, Elodie Ghedin
- Data Sharing Guiding Principles for the NIAID/DMID Systems Biology Program
- Steering Committee for FluOMICS, Omics4TB, FluDyNeMo, and Omics-LHV programs
- Related NIAID-Supported Services