About NIAID ChemDB

The ChemDB HIV, Opportunistic Infection and Tuberculosis Therapeutics Database is a tool developed by NIAID to compile and annotate preclinical data on compounds with potential therapeutic action against HIV/AIDS and related opportunistic infections. This database is continually updated with information extracted from published literature, including the structure and activity of compounds that have been tested against HIV, HIV enzymes or opportunistic pathogens.

Entries in the database are organized according to chemical properties and biological activity. Biological activity is broken down into three categories: activity against HIV in a cellular system, activity against HIV enzymes in a cell-free system, and activity against opportunistic pathogens associated with AIDS.

Opportunistic pathogens included in this database are:

• SIV
• FIV
• Human Cytomegalovirus (HCMV)
• Epstein-Barr virus
• Herpes simplex virus 1
• Herpes simplex virus 2
• Kaposi sarcoma virus
• Hepatitis A virus
• Hepatitis B virus
• Hepatitis C virus
• Mycobacterium spp.
• Pneumocystis carinni
• Cryptococcus spp.
• Candida spp.
• Aspergillus spp.
• Microsporidia
• Toxoplasma gondii
• Cryptosporidium parvum
• Plasmodium spp.*

*Pathogen recently added to our database, so data maybe incomplete

Inclusion or absence of a compound within this database does not imply endorsement or lack thereof by DAIDS, NIAID, NIH or DHHS. Use of this database is for scientific research purposes only and the data should not be used as the basis for any clinical decision.

The ChemDB HIV, Opportunistic Infection and Tuberculosis Therapeutics Database team cannot provide samples of any compound described in this database. In some cases, samples may be available through the NCI/DTP Open Chemical Repository.

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