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Primate Resources for Researchers
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- National Primate Research Centers
- Monkey Research Resources
- Chimpanzee Research Resources
- Chimpanzee Management Program
- Specific-Pathogen-Free Macaque Resources
National Primate Research Centers
FUNDING OPPORTUNITY ANNOUNCEMENT: PAR-11-136 — Limited Competition: National Primate Research Centers (P51)
- Center Access Criteria and Procedures
- California National Primate Research Center
- New England National Primate Research Center
- Oregon National Primate Research Center
- Southwest National Primate Research Center
- Tulane National Primate Research Center
- Washington National Primate Research Center
- Wisconsin National Primate Research Center
- Yerkes National Primate Research Center
Monkey Research Resources
- Baboon Research Resources
- Caribbean Primate Research Center Program
- Squirrel Monkey Breeding and Research Resource
- Vervet Research Colony
Chimpanzee Research Resources
- Alamogordo Primate Facility
- Southwest National Primate Research Center
- University of Louisiana at Lafayette
- University of Texas
- Yerkes National Primate Research Center
- NIH-owned Chimpanzee Research Resource at the SNRPC
Chimpanzee Management Program
Specific-Pathogen-Free Macaque Resources
- Caribbean Primate Research Center SPF Rhesus Monkey Program
- Establishment of a SPF Rhesus Macaque Colony in Texas
- Expansion of a SPF Rhesus Colony in Louisiana
- Production of Pedigreed SPF Rhesus Macaques in California
- SPF Indian Rhesus Monkey Colony in Louisiana
- Specific-Pathogen-Free Rhesus Monkeys in Oregon
- Washington M. nemestrina SPF Breeding Colony
- Expansion of a SPF Rhesus Colony in Georgia
- SPF Indian Rhesus Monkey Colony in New England
Nonhuman Primate Research Reagents
- Creation of a Nonhuman Embryo Gene Expression Resource
- Genetic Typing Laboratory
- Gene-Targeted SNP discovery in rhesus macaques
- NIH Nonhuman Primate Reagent Resource
- Primate Genomics at the University of Washington
- Resource for Nonhuman Primate Immune Reagents
- Primate Resource Referral Service (Listed in the Information Resources section.)
- Wisconsin NPRC Library and Information Service (Listed in the Information Resources section.)
Center Access Criteria and Procedures
The National Primate Research Center (NPRC) facilities and resources enable NPRC staff scientists and investigators from the host institution and others across the country to collaborate on their research projects. The centers' specialized resources are intended to support investigators who receive their primary research project funding from NIH, but they also may be used by investigators who are funded by other federal, state, and local agencies, as well as by research foundations and the private sector. Together the NPRCs have more than 26,000 animals representing more than 20 species of nonhuman primates, mostly macaques.
Each NPRC has a Visiting Scientist Program that offers advanced training and research in nonhuman primate biology. Collaborative arrangements between investigators and center scientific staff are encouraged and can be developed on studies related to major human diseases, subject to the availability of resources and center staff time. Nonhuman primate blood samples, organs, and biological fluids are available through the NPRCs. The following standardized criteria and procedures have been implemented at each NPRC to facilitate utilization of center resources:
Access Criteria
- The nature and scope of the proposed research must be best conducted with nonhuman primates and be compatible with available center resources.
- The proposed research must have high scientific merit as determined by peer review.
- NIH–funded research takes precedence over research activities funded by other sources.
- Grants must contain appropriate budgets for the NPRC portion, including animal per diem costs.
- Availability of NPRC resources, including animals, space, research services and support, and special requirements—such as biosafety facilities— are also limiting factors that must be considered by the investigator.
- Because of potential contamination (e.g., viral, microbial), movement of animals into or out of the NPRC facilities is not allowed. Thus, the proposed research using live animals must use NPRC animals, and the research must be conducted at the NPRC.
Access Procedures
- An initial research proposal must be submitted by the researcher to the NPRC prior to submitting an application for funding. The director then consults with the research services, veterinary, and colony management staff members at the center to assess resource availability and project feasibility. (Note that special requests or conditions regarding animals of certain age, gender, weight, or other stipulations affect the NPRC's capability to meet the researcher's needs.)
- When resource availability and project feasibility have been established, the NPRC staff will provide budget information to the researcher regarding the center costs to be included in the formal research proposal.
- The scientific merit of the proposal must then be evaluated through the NIH peer review process or through a similar process at other agencies. However, small pilot projects with other funding sources may be considered. In the latter case, the peer review is conducted by the NPRC Research Advisory Committee.
- In addition to the scientific peer review, a protocol approved by the Institutional Animal Care and Use Committees (IACUC) at both the investigator's institution and the NPRC must be in place. Protocols must also be established to address biosafety concerns.
- When the investigator has received notification of funding, the NPRC director should be advised immediately so that the resources at the center may be reserved for the funded proposal.
- Biological materials such as blood samples, organ tissues, and biological fluids can be obtained by contacting the directors and staff of the NPRCs.
All publications resulting from research conducted at or with NPRC resources must bear an appropriate acknowledgment of ORIP support.
Inquiries
For additional information about the Visiting Scientist Program and resources available at a specific center, including applying to utilize a center's resources, contact the center director or appropriate contact person listed in this directory.
California National Primate Research Center
Research Emphasis/Objectives
The California National Primate Research Center (NPRC) is a research unit of the University of California, Davis. Its mission is to provide interdisciplinary programs in biomedical research on significant human health-related problems in which nonhuman primates are the most appropriate model for the research.
Current Research
The center has a diverse program of research utilizing nonhuman primates. Research projects encompass many aspects of biology and medicine, including AIDS and other infectious diseases; reproductive issues such as those associated with conception, pregnancy, and fetal growth and development; neurodegenerative conditions such as Alzheimer's disease; nutritional deficiencies; pulmonary disorders such as asthma, emphysema, and other chronic obstructive lung diseases; xenotransplantation; cell- and gene-based therapies; acute and chronic stress; temperament and biobehavioral organization; social relationships; neurobiology; cognitive function; and behavioral development.
Services Provided
Research units include brain, mind, and behavior; reproductive sciences; respiratory diseases; and virology and immunology; as well as an affiliate research program, core services, and the primate services and medicine division. Research opportunities are available for investigators from national and international institutions, as well as scientists within the UC Davis research community. The NPRC is also home to the Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases under the direction of Alice Tarantal, Ph.D.
To Outside Investigators
Specimens
Organs and tissues are provided when available; other biological samples are provided on special request. Shipping, collecting, and processing costs are charged to the requestor.
To Collaborating Scientists
Scientists wishing to conduct research at the center must have their projects reviewed and approved by the center director, research advisory committee, and campus animal care review committee. The center's services are available to collaborating scientists on a fee-for-service basis. Services include:
Core Science
Endocrine Core
Immunology Core
Inhalation Exposure Core
Computational Imaging Core
Pathogen Detection Core
Behavioral Assessment Core Contact Core Directors at 530-752-0447
Primate Medicine
Preventive medicine and epidemiologic evaluation, surgery, radiology, therapeutics, specialized medical procedures.
Diagnostic Pathology and Clinical Laboratory Services
Bacteriology, biochemistry, hematology, parasitology,pathology, virology.
Animals
Center breeding colony: cynomolgus macaque ( Macaca fascicularis ), rhesus macaque ( M.mulatta ). Center research colony: Callicebus moloch, M. mulatta, M. fascicularis .
Contact Information
California National Primate Research Center
University of California, Davis
Davis, CA 95616
Website: www.cnprc.ucdavis.edu
Grant No: P51 OD011107
Center Director and Contact
Dallas M. Hyde, Ph.D.
530-752-0420; Fax: 530-754-6228
E-mail: dmhyde@ucdavis.edu
Additional Contact
Jenny Short
530-752-7169
Principal Investigator
Harris A. Lewin, Ph.D.
The center is located on a 300-acre tract three miles from the main campus of the University of California, Davis. The university administers the center and provides its academic setting.
New England National Primate Research Center
Research Emphasis/Objectives
The New England National Primate Research Center support studies of HIV/SIV/AIDS, oncogenic herpesviruses, other infectious diseases, behavioral biology, neurodegenerative diseases, neurochemistry, brain imaging, and neuropharmacology.
Current Research
Use of simian immunodeficiency virus (SIV) as a model for AIDS in rhesus monkeys, host and viral determinants of AIDS pathogenesis, strategies for vaccine development, immune-based therapeutic strategies, pathogenesis of opportunistic infections. Elucidation of spontaneous diseases of nonhuman primates and development of new models for comparable human diseases. Neurobiology and behavioral pharmacology of cocaine abuse with emphasis on mechanisms of action, behavioral effects, and treatment. Use of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) model for Parkinson's disease, to develop imaging agents for chronic neurologic disorders, to monitor disease progression and effectiveness of therapeutic strategies. Drug discovery and development for central nervous system disorders.
Services Provided
To Outside Investigators
Specimens
Tissue specimens, organs, blood, skeletal structures, viral specimens, etc. Animals for approved research projects are provided from breeding colonies or other sources as required. Costs are normally assumed by the individual requesting the specimens.
To Collaborating Scientists
Scientists wishing to conduct research at the center must have projects reviewed and approved by the center's animal allocation committee. A brochure explaining the collaborative research program is available from the center. Most services are provided on a fee-for-service basis. They include veterinary services, animals and animal care, surgical and radiographic services, timed mating, biocontainment, pathology services, and professional and technical expertise.
Animals
Colonies of rhesus macaque ( Macaca mulatta ), cynomolgus macaque ( M. fascicularis ), common marmoset ( Callithrix jacchus ), and squirrel monkey ( Saimiri sciureus ). Other species can be obtained. Animals with exceptional characteristics (specific-pathogen-free, timed pregnancy, surgically altered, etc.) can be made available if needed.
Contact Information
New England National Primate Research Center
One Pine Hill Drive
P.O. Box 9102
Southborough, MA 01772-9102
Website: www.hms.harvard.edu/nerprc
Grant No.: P51 OD011103
Center Contact for Collaborative Research
Susan Westmoreland, VMD
508-624-8074
Email: susan_westmoreland@hms.harvard.edu
Additional Contact
Roger Spealman, Ph.D.
508-624-8037
Email: roger_spealman@hms.harvard.edu
Principal Investigator
Jeffrey Flier, MD
The center is located on 135 acres in Southborough, Massachusetts, about 30 miles from Boston. Harvard Medical School administers the center and provides its academic setting.
Oregon National Primate Research Center
Research Emphasis/Objectives
The Oregon National Primate Research Center (ONPRC) is engaged in a spectrum of studies based in the scientific research divisions of Reproductive & Developmental Sciences, Neuroscience, and Pathobiology & Immunology. This research is complimented by interdisciplinary programs in the areas of metabolic disease, stem cell therapy, addiction, child health, healthy aging and primate genetics. Collaborative research that is initiated by external investigators is managed through the Collaborative Research Unit (CRU).
Current Research
- Reproductive & Developmental Sciences: Regulation of the primate hypothalamus, pituitary, ovary, reproductive tract and maternal-fetal-placental unit, as related to improving the diagnosis and treatment of infertility, including in cancer patients, plus other reproductive health and pregnancy-related disorders. Assisted reproductive technologies to identify and improve gamete quality and to develop nonhormonal methods of contraception.
- Neuroscience: Neurological and genetic processes in neuroendocrine regulation, neurodegenerative diseases, addictive disorders, adult neurogenesis, developmental neurobiology, cognitive decline, and systems biology.
- Pathobiology & Immunology: Cellular and molecular events controlling pathogenesis and immune responses of clinically important infectious agents (HIV/SIV, herpes family viruses, Mycobacterium tuberculosis, yellow fever virus, Dengue, Chikungunya virus), novel vaccine development, and research in basic primate immunology, immune senescence and bioterrorism (Regional Center for Excellence).
- Metabolic Disease Program: Diet-induced maternal obesity, metabolic syndrome and insulin resistance, adipose biology and islet function.
- Stem Cell Therapy Program: Embryonic stem cell and induced pluripotent stem (iPS) cell approaches to study epigenetic, genetic, and cellular mechanisms of growth, development, and morphogenesis as related to regenerative medicine.
- Healthy Aging Program: Dietary modulation of age-related changes in immune function, circadian physiology, and learning and memory, efficacy of endocrine therapies for postmenopausal declines in cognition and emotional health.
Animal Colony
Rhesus macaques (Macaca mulatta), ~4,200; Japanese macaques (Macaca fuscata), ~350; cynomolgus macaques, ~100; Baboons (Papio anubis), relatively few. Specialized animal resources: Obese resource (Japanese and rhesus macaque models of diet-induced obesity); Aging resource (aged rhesus macaque cohort); Primate Genetics Program (colony ancestry, pedigree genetics, demographics and biostatistics); Behavioral Sciences Unit; Timed Mated Breeding Program; Infant Lab; and a BSL-3 animal research facility. Colony care and maintenance is the responsibility of the Division of Animal Resources, which includes 15 full-time veterinarians and ~110 support staff.
Services Provided
To Outside Investigators
Tissue specimens, organs, etc., as available from Pathology Services tissue procurement program. Costs are assumed by the requestor.
To Collaborating Scientists
Scientists wishing to conduct research at the ONPRC must have their projects approved by the Institutional Animal Care and Use Committee, the Institutional Biosafety Committee, and the Research Advisory Committee (RAC). The RAC does not typically evaluate proposals that undergo formal peer review by national review panels (i.e., NIH, DOD, etc.). Investigators interested in collaborative work who do not have an existing relationship with an ONPRC investigator should direct enquiries to the CRU, which is headed by the Associate Director for Research (contact information below). Collaborators have access to ONPRC research support cores, which are listed below. Most services are provided on a fee-for-service basis.
Pathology Services tissue procurement program
Necropsies, tissue distribution, consultation.
Imaging and Morphology
Confocal and laser-capture microscopy and stereology, tissue embedding and sectioning, immunohistochemistry, in situ hybridization.
Endocrine Technology Services
Steroid and protein hormone Luminex, ELISAs, IRMAs, and RIAs, assay development.
Medical Illustrations and Photography
Poster preparation and printing, graphics.
Molecular and Cellular Biology
DNA synthesis and sequencing, cDNA probes, real-time PCR, maintenance of cell lines, media preparation, lentivirus design and preparation.
Assisted Reproductive Technologies
Procedures related to in vitro fertilization, nuclear transfer, intracytoplasmic sperm injection, culture media, gamete preservation.
Magnetic Resonance Imaging
3T Siemens magnet, magnetic resonance spectroscopy, MRI training.
Research Immunology
Flow cytometry.
Molecular Virology
Virus identification, production, and quantification, reagent and standardized assay development.
Library
6,400 books, 10,150 bound journals, 70 journal subscriptions, 2,000 online journals, 113 databases, ILL and reference services.
Contact Information
Oregon National Primate Research Center
Oregon Health & Science University
505 N.W. 185th Avenue
Beaverton, OR 97006
Website: onprc.ohsu.edu
Grant No.: P51OD011092
Center Director and Contact
Nancy L. Haigwood, Ph.D.
503-690-5500; Fax: 503-690-5569
E-mail: HaigwooN@ohsu.edu
Associate Director for Research
Charles Roberts, Ph.D.
503-690-5259; Fax: 503-690-5569
E-mail: RobertsC@ohsu.edu
Principal Investigator
Joseph Robertson, M.D.
President, Oregon Health & Science University
Portland, Ore. 97239
The 160-acre center is located on the 24-acre Oregon Health Sciences University West campus 12 miles from downtown Portland. OHSU provides its academic setting.
Southwest National Primate Research Center
P51OD011133
Research Emphasis/Objectives
The Southwest National Primate Research Center (SNPRC) supports studies of nonhuman primate models of human diseases, including common chronic diseases and infectious diseases, and the effects that genetics and the environment have on physiological processes and susceptibility to specific diseases.
Current Research
Chronic Diseases
Genetic and environmental bases for susceptibility to atherosclerosis, hypertension, osteoporosis, obesity, and cancer; construction of baboon and rhesus gene maps; genome scans for disease-related genes; therapeutic monoclonal antibodies; development of new genetic analysis strategies and software.
Infectious Diseases and Biodefense
AIDS; hepatitis B, C, and E; herpes B and other herpes viruses; Chagas disease; hemorrhagic fevers; emerging viral diseases; vaccine and drug development and testing.
Development and Aging
Contraception; nutrient restriction or obesity in pregnancy and developmental programming; ingestive behavior; brain imaging; gene and stem cell therapies
Services Provided
To Outside Investigators
The SNPRC encourages the use of its resources by investigators from the national and international biomedical research communities. The SNPRC is also available for collaborative research initiatives involving center staff and outside investigators. In general, expenses are assumed by the initiating investigator, and collaborative research efforts are covered by grants acquired collaboratively.
Specimens
Banked serum, tissue, and DNA samples; fresh blood, serum, plasma, tissues, and organs.
Animals
Baboons, (Papiohamadryasanubis, P.h. cynocephalus), chimpanzees (Pan troglodytes), rhesus macaques (Macaca mulatta), common marmosets (Callithrixjacchus), miscellaneous primate species as required for specific research purposes. Also, rhesus macaques with an LDL receptor defect that causes familial hypercholesterolemia.
Veterinary Technical Services
Timed pregnancies, tether, radiography, sonography, endoscopy, experimental surgery, experimental diets, nursery, behavioral assessment. ABSL-3 and ABSL-4 laboratories are available for infectious disease research, including research with Select Agents.
Pathology Services
Necropsies, clinical chemistry, hematology, histology, bacteriology, virology, parasitology.
Immunology Services
Flow cytometry, cytokine and hormone Luminex assays, ELISA, ELISPOT, viral screening, cell separation.
Data Services
Colony database system, genetic analysis software, genetic typing services.
Contact Information
Texas Biomedical Research Institute
Southwest National Primate Research Center
P. O. Box 760549
San Antonio, TX 78245-0549
Website: http://www.txbiomed.org/primate-research-center
Center Director and Contact:
John L. VandeBerg, Ph.D.
Phone: 210-258-9430
E-mail: jlv@txbiomedgenetics.org
Principal Investigator
Kenneth P. Trevett, J.D.
The center is located on the 200-acre campus of the Texas Biomedical Research Institute, approximately 12 miles from downtown San Antonio and 7 miles from the University of Texas Health Science Center at San Antonio. Texas Biomed administers the center.
Tulane National Primate Research Center
Research Emphasis/Objectives
The Tulane National Primate Research Center is heavily focused on infectious disease research and also has a significant program in gene therapy/regenerative medicine that capitalizes on a unique colony of macaques with Krabbe disease.
Current Research
The major areas of infectious disease research at the Center are currently AIDS, Lyme disease, Tuberculosis and biodefense-related agents. The AIDS-related research is quite diverse, covering pathogenesis, vaccine development, microbicides, and the origins of AIDS. These are multidisciplinary studies involving investigators in several Divisions at the TNPRC and collaborators outside the Center. Common to these studies is a focus on disease pathogenesis and on using such findings to inform the development of vaccines, diagnostics and therapeutics. The regenerative medicine program involves both traditional viral-vector-mediated gene transfer as well as nonhuman primate mesenchymal and embryonic stem cells. For more information, visit: www.tnprc.tulane.edu
Services Provided - To Outside Investigators
Specimens: Tissue specimens, blood, and other bodily fluids are provided when available. Collection, processing, and shipping costs are normally assumed by the requestor.
Services Provided - To Collaborating Scientists
The TNPRC provides highly integrated clinical and laboratory support for studies using nonhuman primates. This includes a full-time staff of clinical veterinarians and technicians and core services commonly used for infectious disease and gene therapy research including: 1) Diagnostic Parasitology; 2) Vector-Borne Diseases (maintains arthropods that are important for the study of vector-borne diseases); 3) DNA Microarray and Gene Expression; 4) Anatomic Pathology; 5) Clinical Pathology; 6) Molecular Pathology; 7) Confocal Microscopy and Image Analysis; 8) Flow Cytometry; 9) Cellular Immunology; 10) Virus Characterization, Isolation, and Production; 11) Pathogen Detection and Quantification; 12) Infectious Disease Aerobiology; 13) Genetics and Genome Banking; 14) Vector Development and Production; and 15) Nonhuman Primate Stem Cell Production. For more information, visit www.tnprc.tulane.edu/research_resou.html .
Animals
Rhesus macaques (Macaca mulatta) of both Indian and Chinese origin are available. Other species can be obtained. Most of the rhesus macaques are specific-pathogen free (B virus, SIV, SRV, and STLV1 negative).
Contact Information
Tulane National Primate Research Center
18703 Three Rivers Road
Covington, LA 70433
Website: www.tnprc.tulane.edu
Grant No.: P51 OD011104
Center Director and Contact
Andrew A. Lackner, D.V.M., Ph.D., Dipl. A.C.V.P.
985-871-6201; Fax: 985-871-6569
E-mail: tnprc@tulane.edu
Additional Contact
Rudolf P. Bohm
985-871-6362
E-mail: TNPRC-VetMed@tulane.edu
Principal Investigator
Benjamin P. Sachs, M.B., B.S., DPH, FACOG
The Center is part of the Tulane University Health Sciences along with the School of Medicine and School of Public Health & Tropical Medicine and is located on 500 acres near Covington, Louisiana, 35 miles from the main campus.
Washington National Primate Research Center
Research Emphasis/Objectives
The Center’s mission is to support outstanding biomedical research directed towards significant human health issues and nonhuman primate health and biology.
The Center’s program emphasizes integration of research support, animal care and administrative activities to meet the needs of the nonhuman primate (NHP) research community. The Center’s scientists conduct a wide variety of fundamental andtranslational research protocols, investigate NHP biology and disease, support a broad affiliate scientist program, develop innovative technologies, and provide training to the scientific community and public.
Current Research
Scientists conduct basic and translational research supported by highly experienced support staff and withaccess to a variety of dedicated facilities required for NHP research protocols. The Center’s research divisions are described below:
AIDS-Related Diseases
Providing expertise and resources to better understand, prevent and treat HIV and AIDS.Scientists provide contributions to AIDS research including characterization of the virus-host interaction, restriction factors, immune response, and development of new vaccines and therapeutics.
Nonhuman Primate Systems Biology
Using high-throughput molecular profiling, statistical analysis and computational modeling to understand infection, pathogenesis, and immunology.
Global Programs
Focusing on conservation biology, field study training and international outreach activities. Areas of focus include NHP population status, genetic characterization, habitat viability, population management, disease risk and sustainability modeling.
Neuroscience
Using the NHP model to answer questions about the nervous system, vision and more. Current research includes applications of gene therapy toward color vision research, exploration of treatments for spinal cord injuries and paralysis using electronic neurochips, andtreatments for balance disorders using implanted devices.
Reproductive & Developmental Sciences
Exploring reproductive biology and cognitive development in NHPs. The division includes a new core service providing macaque embryonic stem cells.
Evolutionary Emergence of Infectious Diseases
Understanding how interspecies interaction leads to the emergence of disease.
Venture/Pilot Program
Providing specialized facilities, expertise and support to investigators with approved projects.
Services Provided
Affiliate Scientists/Outside Investigators
The Center is committed to providing complete access to resources for the research community to facilitate all aspects of nonhuman primate-related research. The Center provides substantial assistance for collaborative research projects, including scientific and technical assistance with protocol development, grant submission, data collection and interpretation, and manuscript preparation.
Primate Resource Referral Service (PRRS)
The Primate Resource Referral Service (PRRS) provides the communications/database network needed for efficient acquisition and sharing of existing captive NHPs and primate-related resources by investigators and institutions both nationally and internationally. The overall goal of this service is to maximize the use of existing captive primates, thereby reducing the total number of NHPs needed for research, and in turn, helping to promote the conservation of primate populations.
Comparative Pathology Services (CPS)
CPS provides sophisticated comparative pathology services to Center veterinarians, core scientists, UW researchers, and affiliate and outside investigators. The CPS pathologists also have adjunct faculty appointments in the UW Department of Comparative Medicine (DCM), and interact with pathologists and laboratory animal veterinarians of the DCM. With ancillary support and consultation provided by DCM pathologists together with their technicians and laboratories, WaNPRC and DCM pathologists provide an extent of expertise which neither entity could alone support. The CPS also provides a training resource for students enrolled in the DCM post-DVM training programs of laboratory animal medicine and anatomic pathology.
Tissue Distribution Program
The Tissue Distribution Program provides NHP tissue samples to a broad variety of biomedical scientists. This program is an NPRC leader in distribution of biologic samples to both academic and commercial biomedical researchers. Staff continue to modify tissue extraction, preservation, and shipping techniques to meet research needs and extend the use of this valuable NHP resource.
Colony Services
Services include NHP health care, surgical procedures, imaging facilities, genetic characterization, clinical laboratory, round-the-clock nursery care, computerized genealogic and clinical records using the Animal Research Management System (ARMS), psychological well-being, preventive medicine, and consultation.
Biostructure Technology Laboratory
Services include the following:
- The Neurohistology Section is equipped and staffed to assist researchers in the production of brain sections suitable for microscopic analysis and whole specimens for high-resolution MRI.
- The Microscopy/Image Processing Section is a shared instrument facility that provides semi-automatic acquisition, analysis and storage of images, both microscopic and macroscopic, for anatomical aspects of neurobehavioral studies at the WaNPRC and remote institutions via the Web.
- BrainInfo/NeuroMaps (http://braininfo.org) is an international web-based informatics resource that provides neuroscientists immediate access to detailed information about classical brain structures of the human, macaque, rat and mouse.
Bioengineering Services
Bioengineering Services provides technical support for neuroscience research using NHPs. This includes selection or design of equipment forexperiments, fabrication/modification/repairof customized instrumentation, andmaking designs available to the larger NHP research community.
Infant Primate Research Laboratory (IPRL)
The IPRL provides services to investigators using infant NHPs as animal models for behavioral and biological research. The IPRL is supported as a core facility of both the WaNPRC and the UW Center on Human Development and Disability.The IPRL provides around-the-clock care for pregnant females and infants in order to optimize survival and minimize morbidity. This effort increases the number of healthy animals available to the overall primate colony and reduces costs to investigators.
Timed Mating Breeding Program
In this program, the Center has the ability to produce gestation-known fetuses and infants for investigators through daily menses tracking using a noninvasive observational method. This is particularly important for our current studies requiring early gestation interventions or experimental treatments that may affect gestation length.
High-Throughput Molecular Profiling Core
This lab is a resource for scientists to obtain datasets by oligonucleotide microarray, next-generation sequencing, and proteomics. The core has particular expertise in applying these methods to NHP research, and has the instrumentation, computing infrastructure, personnel, and long-term experience necessary for running large numbers of samples and working with large volumes of data.
Biosafety Level 3 (BSL-3) Facility
The BSL-3 facility uses unidirectional airflow and high efficiency particle air (HEPA) filtration to control aerosols and remove infectious organisms from the air. This enables the Center to maintain a degree of readiness to rapidly respond to a human infectious disease outbreak, a principal function of all NPRCs.
Virology/Immunology Service Core
This core provides services in the following areas: (1) Sample processing, including isolation of plasma, serum and PBMC, and processing of various tissues, e.g., lymph node, vaginal wash, etc.; (2) Lymphocyte immunophenotyping and hematology; (3) Virus isolation by coculture; (4) Viral load determination by various PCR methods; (5) Serology, including ELISA, and immunoblots assays in multiple formats; and (6) Virus stocks and viral antigens.
Primate Diagnostic Services Laboratory (PDSL)
The PDSL helps to fulfill the Center’s mission to provide healthy, research-ready NHPs for biomedical research through regular monitoring for evidence of select simian viruses. Additionally, the PDSL plays a crucial role in the Center’s colony breeding programs through timely notification of colony managers of the virus infection status of all NHPs in the breeding colonies.
Animals
Pigtailed macaque (Macacanemestrina), Cynomolgus macaque (Macacafascicularis), rhesus monkey (Macacamulatta), squirrel monkey (Simiasciureus)
Collections
A broad variety of collections are archived encompassing developmental and physiologic data for the nonhuman primate.
Contact Information
Washington National Primate Research Center
University of Washington
I-421 Health Sciences
Box 357330
Seattle, WA 98195-7330
Website: www.wanprc.org
Grant No.: P51 OD010425
Center Director and Contact
David M. Anderson, D.V.M.
206-543-1430; Fax: 206-616-6771
E-mail: directorsoffice@wanprc.org
Tissue Distribution
206-616-8122
E-mail: necropsy@wanprc.org
Principal Investigator
Thomas M. Baillie, PhD, DSc
Dean, UW School of Pharmacy
Professor of Medicinal Chemistry
The center is located in the Warren G. Magnuson Health Sciences Center of the University of Washington and at the Western Facility Annex in Seattle.
Wisconsin National Primate Research Center
Research Emphasis/Objectives
The WNPRC's mission is to increase our understanding of basic primate biology and to improve human health and quality of life through research. To accomplish this, the WNPRC:
- Helps discover treatments, preventions and cures for human disease.
- Generates new knowledge of primate biology, from the molecular and whole animal levels to the understanding of primate ecosystems.
- Facilitates research progress by providing expertise, resources and training to scientists worldwide.
- Collects primate information and disseminates to the research community and to the public.
Quick Facts:
- Personnel: The WNPRC supports research by more than 250 core and affiliate scientists from the UW-Madison, across the U.S. and around the world. Many graduate students and post-doctoral trainees also conduct research through the Center.
- Funding: $91 million including core and affiliate scientists' total funding. Of that, $38.5 million supporting subprojects using Primate Center resources. Of that, $4.2 million in non-federal funding, primarily foundations and industry.
- Colony: 1,411 animals: 1,106 rhesus macaques, 260 common marmosets, 45 cynomolgus macaques.
Current Research
The WNPRC supports three areas of major emphasis and a diverse affiliate program.
Aging and Metabolic Diseases
- Effects of caloric restriction on aging
- Obesity
- Diabetes mellitus
- Osteoporosis
- Ocular aging (glaucoma, presbyopia)
- Neurodegeneration
- Gene expression profiling
- Parkinson's Disease
Immunogenetics and Virology
- Simian immunodeficiency virus
- HIV vaccines
- Simian immunodeficiency virus
- MHC-defined animals
- Cytotoxic T-cells
- Molecular MHC analysis
Reproduction and Development
- Embryonic stem cell biology
- Fertility regulation
- Embryonic differentiation
- Maternal-fetal health
- Reproductive neuroendocrinology
- Polycystic ovarian syndrome
- Endometriosis
- Reproductive tract gene therapy
Services Provided
To Outside Investigators
Researchers interested in conducting research through the WNPRC and using one of the below services or resources should first contact our Centralized Protocol Implementation Unit (CPI) .
CPI integrates and utilizes research service and animal service personnel and their talents to make research programs function in a precise and efficient manner. This integration serves as a gateway for the use of the NPRC and all its service units in research projects for both local and extramural principal investigators.
Research Services:
- Assay Services
- Genetics
- Immunology
- Virology
Research Resources:
- Aging Resource
- Stem Cell Resource
Animal Services:
- Behavioral Management Unit
- Colony Management Unit
- Compliance and Training Unit
- Veterinary Services Unit
- Pathology Services (tissue specimens, organs, other biological materials.)
To Collaborating Scientists
The center actively encourages researchers from the Midwest region and as well as national and international to use its facilities and services and to conduct collaborative studies. Scientists wishing to conduct research must have their projects reviewed and approved by the center director and advisory committees and have independent funding to cover costs. Most of the center's services are available on a fee-for-service basis.
Contact Information
Wisconsin National Primate Research Center
1220 Capitol Court
Madison, WI 53715-1299
Website: www.primate.wisc.edu
Grant No.: P51 OD011106
Center Director and Contact
Jon Levine, Ph.D.
608-263-3500; Fax: 608-265-2067
E-mail: levine@primate.wisc.edu
Additional Contacts
Jordana Lenon
Public Information and Outreach
608-263-7024
jlenon@primate.wisc.edu
Ray Hamel, M.L.S.
Library and Information Services
608-263-3512
E-mail: hamel@primate.wisc.edu
refdesk@primate.wisc.edu
Principal Investigator
Martin T. Cadwallader, Ph.D.
The center has approximately 120,000 square feet of laboratory, animal, office, and related support space on and near the University of Wisconsin-Madison campus. The UW-Madison Graduate School provides center's administrative support and academic setting.
Yerkes National Primate Research Center
Research Emphasis/Objectives
The Yerkes National Primate Research Center conducts biomedical and biobehavioral research to improve the health and well-being of human and nonhuman primates.
Current Research
Microbiology and Immunology
Advance molecular and biological processes for understanding, preventing, and treating infectious diseases; primate models for research on AIDS pathogenesis, treatment, and vaccines; and for other infectious diseases including malaria and TB.
Behavioral Neuroscience and Psychiatric Disorders
Conducts basic and translational research to understand the neurobiological mechanisms underlying behaviors relevant to developmental and psychiatric conditions such as autism spectrum disorders, anxiety-related disorders, depression, and post-traumatic stress disorders (PTSD).
Developmental and Cognitive Neuroscience
Examines the neurobiology of social behavior and cognition across the life span; genetic, biological, and environmental factors that regulate social behavior and cognition; how social experience affects physiological processes and brain function.
Neuropharmacology and Neurological Diseases
Focuses on neurochemistry and neuroanatomy of neurologic disease; mechanisms of drug addiction and dynamics of drug receptors; cognitive changes with aging and neurologic disease; oculomotor processing under normal and pathological conditions.
Services Provided
To Outside Investigators
Research proposals by investigators from other institutions are encouraged. Proposals should be submitted for review by the Scientific Advisory Committee (SAC) to ensure that resources are available. All proposals are reviewed by the Institutional Animal Care and Use Committee. Services available to outside investigators at approved rates include veterinary medicine, pathology, and biomedical engineering.
Animals
Rhesus macaque ( Macaca mulatta ), paigtailed macaques (M. nemestrina), cynomolgus macaque (M. fascicularis), sooty mangabey (Cercocebus atys), squirrel monkey (Saimiri sciureus), chimpanzees (Pan troglodytes).
Service Cores
Brain Imaging and Radiochemistry, Molecular Pathology, Center for AIDS Research (CFAR) Virology, Genomics, Biomarkers, NIH Tetramer, Confocal Microscope, Comparative AIDS Core, Flow Sorting, Rodent Vivarium.
Contact Information
Yerkes National Primate Research Center
Emory University
954 North Gatewood Road, N.E.
Atlanta, GA 30322
Website: www.yerkes.emory.edu
Grant No.: P51 OD011132
Center Director and Contact
Stuart Zola, Ph.D.
404-727-7707; Fax: 404-727-0623
E-mail: szola@rmy.emory.edu
Principal Investigator
Michael M. E. Johns, M.D.
Center facilities include the Main Station on 25 acres of the Emory University campus in Atlanta and the 117-acre Field Station for psychobiology research in nearby Lawrenceville.
Baboon Research Resources
P40OD010988
Research Emphasis/Objectives
The Baboon Research Resource conducts multidisciplinary studies on captive baboons and provides a resource of laboratory-born and laboratory-reared baboons for NIH-sponsored research programs. Additional objectives are to: maintain and provide available research facilities accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International; serve as a ready source of baboons ( Papio spp. ) of mixed ages and sex for use in biomedical and behavioral sciences; and provide professional staff necessary to support investigators' research needs.
Current Research
Current research activities involve characterizing the endogenous microorganisms of the conventional research baboon, improving methods for production of baboons in a captive environment, developing a specific-pathogen-free colony of baboons, developing vaccines, and testing genetic diversity among the baboon breeding population.
Services Provided
To Outside Investigators
The mission of the Oklahoma University Health Sciences Center (OUHSC) Baboon Research Resource is to support biomedical and behavioral research requiring the baboon as the animal model. The resource supports research investigators at the OUHSC and also serves as a national resource by supporting numerous investigators located at institutions across the United States. This resource enables NIH-funded investigators to purchase baboons for their research programs, subcontract with the resource to conduct the study on location at the OUHSC, or lease the baboons for conducting their studies and then return the baboons to the breeding colony. Together with the Oklahoma State University College of Veterinary Medicine, the Oklahoma State University Center for Health Sciences, and the Texas Tech University Health Sciences Center, the resource continues to further develop and improve the usefulness of the baboon as an animal model.
To Collaborating Scientists
Individuals interested in collaborative studies must provide a protocol to the principal investigator of the Baboon Research Resource. Approval of collaborative projects depends on the relevance of the proposed project to the objectives of the Baboon Research Resource, with preference given to NIH-funded studies. Complete animal husbandry, veterinary medical care, technical assistance, and pathology services are available to investigators who have approval from the principal investigator to use resource colony animals.
Animals
Adult, infant, and juvenile baboons are available.
Contact Information
Baboon Research Resources
University of Oklahoma Health Sciences Center
Division of Animal Resources
940 S. L. Young Boulevard, BMSB 203
Oklahoma City, OK 73190
Principal Investigator and Contact
Gary L. White, D.V.M., M.M.S.
405-271-5185; Fax: 405-271-2660
E-mail: gary-white@ouhsc.edu
Additional Contact
Richard W. Eberle, Ph.D.
405-744-8169; Fax: 405-744-5275
E-mail: reberle@okstate.edu
Caribbean Primate Research Center Program
P40OD012217 -Melween Martinez, DVM (PI)
U24OD10421- Carlos A. Sariol, MD (PI)
U42OD11128 - Carlos A. Sariol, MD (PI)
Research Emphasis/Objectives
Cayo Santiago
Short- and long-term studies of social and sexual behavior, population genetics, demography, reproductive biology, psychopharmacology, functional morphological and spontaneous diseases (arthritis, osteoporosis, adult-onset macular degeneration, glaucoma, diabetes, obesity, hypertension), and parasitoses of rhesus monkeys maintained under seminatural conditions. Colony size: 1000.
Sabana Seca Field Station
Headquarters of the Caribbean Primate Research Center (CPRC), specific-pathogen-free (SPF) rhesus breeding colony and biomedical research on spontaneous diseases (see above), reproductive biology and embryology, social behavior, endocrinology, medical genetics, vaccine development, and husbandry of Cayo Santiago-derived rhesus macaques maintained under a variety of housing configurations (individual cages, pens, and large corrals). Colony size: 2,700.
Laboratory for Primate Morphology and Genetics (formerly known as CPRC museum)
Anthropological and biomedical osteological research on 2,500 complete skeletons from 10 species of nonhuman primates, including more than 1,000 from Cayo Santiago rhesus monkeys of known identity, age, sex, matriline, and parity, and 175 skeletons from patas monkeys.
Virology Laboratories
Research on simian immunodeficiency virus (SIV, as a model for AIDS in rhesus monkeys) and on strategies for the development of vaccines against SIV and dengue viruses. This BL2/3 fully equipped laboratory also supports the SPF grants by performing serological testing of herpes, STLV-1, SRV, and SIV in rhesus macaques.
Services Provided:
CPRC welcomes collaborative research with established behavioral and biomedical investigators and encourages the use of its animal and osteological resources for dissertation research. Investigators are charged modest use fees for access to the animals, computerized database, and office space. All proposals receive rigorous peer review and are judged on scientific merit, feasibility, and potential overlap with ongoing studies. Protocols using live monkeys must be approved by the Institutional Animal Care and Use Committee (IACUC) of the home institution, as well as the University of Puerto Rico Medical Sciences Campus IACUC.
The CPRC has an on-site postmortem service for the non-human primate population that provides direct consultation and collaboration with veterinary clinicians and research investigators. Postmortem evaluation, which includes detailed gross and histopathological examination, is performed by a board certified anatomic pathologist. Post-mortem examination of animals includes collection of tissue samples for bacterial and/or viral cultures, molecular diagnostics and toxicology workup if necessary. Formalin fixed and fresh frozen tissues of all vital organs are archived. Other specialized procedures such as perfusions, interpretation of specials stains, immunohistochemistry are also available.
The CPRC also has rhesus monkeys available for sale for NIH Research Investigators. We are the second largest provider of conventional and SPF Indian-origin rhesus macaques (Macaca mulatta) for PHS sponsored research projects.
For additional information, please send an email to the following address: cprc.rcm@upr.edu.
Contact Information
Caribbean Primate Research Center Program
University of Puerto Rico Medical Sciences Campus
P.O. Box 1053
Sabana Seca, PR 00952-1053
Principal Investigator and CPRC Director Contact
Melween I. Martinez, DVM.
Main: 787-784-0322, Fax: 787-795-6700
E-mail: melween.martinez@upr.edu
Principal Investigator
Carlos A. Sariol, MD
787-758-2525 ext. 5112 or ext. 1189; Fax: 787-767-1442
E-mail: carlos.sariol1@upr.edu
Mailing Address
Caribbean Primate Research Center Program
University of Puerto Rico Medical Sciences Campus
P.O. Box 1053
SabanaSeca, PR 00952-1053
Squirrel Monkey Breeding and Research Resource
Research Emphasis/Objectives
Research objectives are to carry out multidisciplinary studies of reproduction in squirrel monkeys, to search for models relevant to human health, and to provide a resource of laboratory-born and -reared animals for NIH-sponsored research programs.
Current Research
Characterizing factors that influence captive reproduction with emphasis on developing methods to improve reproductive potential. A multidisciplinary approach—including behavioral studies, reproductive endocrinology, medical primatology, and genetics—is ongoing
Services Provided
To Outside Investigators
Tissues and body fluids are available. Such specimens are provided on a priority basis to NIH-sponsored research studies that are related to the objectives of this project. Costs of packaging and shipping are negotiated on an individual basis to be determined by the nature of the collaboration.
To Collaborating Scientists
Individuals interested in collaborative studies must provide a protocol to the principal investigator. Approval of collaborative projects depends on the relevance of the proposed project to the objectives of the ongoing research effort. Complete animal husbandry, medical care, and pathology services are available without charge to investigators who have received approval from the principal investigator to use resource colony animals.
Animals
The breeding colony currently contains approximately 450 squirrel monkeys of varying ages. Some offspring and reproductive culls are available.
Core Staff
Investigators conducting studies of medical primatology, reproductive endocrinology, data management, primate management and husbandry, primate behavioral psychology, and genetics.
Guest Investigators and Graduate Students
Guest investigators and graduate students interested in studies of factors influencing reproduction of squirrel monkeys in captivity are invited to send letters of interest. These letters will be considered based on the relevance of the applicant's interests to the ongoing research effort and the availability of resources to meet the needs of the guest investigator.
Contact Information
UT M.D. Anderson Cancer Center
Center for Neotropical Primate Research and Resources
Michale E. Keeling Center for Comparative Medicine and Research
Department of Veterinary Sciences
650 Cool Water Dr.
Bastrop, TX 78602
Website: www.kccmr.org
Principal Investigator and Contact
Christian R. Abee, D.V.M.
512-321-3991; Fax: 512-332-7312
E-mail: cabee@mdanderson.org
Vervet Research Colony
Research Emphasis/Objectives
The colony emphasizes development of the vervet as an alternative to the rhesus monkey for biomedical research applications. The objectives are to provide SPF animals, husbandry information, access to the pedigreed and genotyped colony for research manipulations, and access to the repository for hypothesis testing and pilot data generation.
Current Research
Current research includes assessment of: 1) genetic, neurobiological, and behavioral correlates of obesity, insulin resistance, diabetes, osteoporosis, and osteoarthritis; 2) genetic, developmental, and neurobiological influences on traits related to vulnerability for psychopathology; and 3) social, endocrine, and dietary effects on pregnancy outcomes and individual development across the lifespan.
Services Provided
This resource will provide approximately 100 animals per year for biomedical research, including some selected for particular traits (e.g., old age, insulin resistance, and impulsivity) or genotypes. Individuals wishing to collaborate on site can be provided with access to the colony for phenotypic or genetic assessment or for the conduct of discrete experiments. Technical support and complete anatomic and clinical pathology services are available. There is also scientific support for statistical genetic analyses.
Contact Information
Wake Forest University Primate Center
Wake Forest University School of Medicine
Medical Center Blvd.
Winston-Salem NC 27157-1040
E-mail: wfupc@wfubmc.edu
Web Site: http://www.wakehealth.edu/wfupc/
Principal Investigator and Contact
Jay R. Kaplan, Ph.D.
336-716-1522; Fax: 336-716-1515
E-mail: jkaplan@wfubmc.edu
Additional Contact
Matthew J. Jorgensen, Ph.D.
336-716-6935; Fax 336-716-1515
Alamogordo Primate Facility
Research Emphasis/Objectives
The Alamogordo Primate Facility (APF) houses chimpanzees that have been used in biomedical research, but no active, invasive research is conducted on the site.
Services Provided
The APF provides for the long-term care and husbandry of chimpanzees that have been used in biomedical research. Charles River Laboratories Inc. operates the facility under contract with the National Institutes of Health. To be used in continuing virological research, the animals must be transferred to active chimpanzee research settings.
Animals
All chimpanzees at the APF have been exposed to various microorganisms, such as hepatitis C virus and HIV. For this reason, they may be candidates for studies related to these diseases. The Office of Research Infrastructure Programs (ORIP) may remove infected animals from the APF to other accredited chimpanzee facilities for research purposes. Investigators interested in the chimpanzees at the APF should contact Dr. Harold Watson in ORIP's Division of Comparative Medicine to discuss research requirements. Dr. Watson can be reached at 301-435-0744.
Contact Information
Alamogordo Primate Facility
Holloman Air Force Base
Alamogordo, NM 88330
Contact
Harold Watson, Ph.D.
301-435-0744; Fax: 301-480-3819
E-mail: watsonh@mail.nih.gov
University of Louisiana at Lafayette
Research Emphasis/Objectives
The center maintains and provides available research facilities accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International; a ready source of chimpanzees of mixed ages and sex for use in biomedical and behavioral sciences, and also provides professional staff necessary to support investigators with their research needs.
Current Research
Vaccine development and testing; pharmacokinetic, pharmacodynamic, preclinical safety, and efficacy studies.
Services Provided
The University of Louisiana at Lafayette-New Iberia Research Center (UL Lafayette-NIRC) is an AAALAC-International-accredited nonhuman primate research facility dedicated to the support of basic and applied biomedical and behavioral research. All proposed programs must be approved by the presenting institution and the UL Lafayette-NIRC animal care and use committees. State-of-the-art biomedical support facilities are available that include access to ultrasound, radiography with automatic processor and computer imagery for diagnostic enhancement, and endoscopy and laparoscopy with video monitors, camera and color photo imagery.
Diagnostic Laboratory
A 12,000-square-foot laboratory is available for investigators' research support requirements. Capabilities within the laboratory include—but are not limited to—hematology, chemistry, microbiology, urinalysis, parasitology, and histology. Among the investigator support procedures are Ficoll gradient isolation of peripheral blood mononuclear cells, platelet aggregation profiles, nonhuman primate lymphocyte proliferation assay, and flow cytometry (lymphocyte enumeration). Emergency generator power is accessible in each laboratory unit and for all major instrumentation and critical freezers.
Animals
The center cares for approximately 360 chimpanzees and 5,500 New and Old World species of nonhuman primates. In addition to chimpanzees, the following species of nonhuman primates are being bred at the center: Vervet monkey ( Chlorocebus aethiops ), cynomolgus macaque ( Macaca fascicularis ), pigtailed macaque ( M. nemestrina ), rhesus macaque ( M. mulatta ).
Contact Information
University of Louisiana at Lafayette
New Iberia Research Center
4401 West Admiral Doyle Drive
New Iberia, LA 70560
Website: nirc.louisiana.edu
NIH-Owned Chimpanzee Research Resource at the SNPRC
U42OD011184
Research Emphasis/Objectives
This project, which is located at the Southwest National Primate Research Center (SNPRC) in San Antonio, Texas, supports NIH-owned chimpanzees and makes them available for qualified research by academic and commercial investigations. The research is primarily focused on vaccines and therapeutics for hepatitis C and on testing of therapeutic humanized monoclonal antibodies. However, the chimpanzees are available for other purposes as well.
Services Provided
Chimpanzees are available for use at the SNPRC in qualified research projects. SNPRC staff who are highly skilled and experienced in all procedures that are commonly used in research with chimpanzees conduct the experimental procedures and sample collection for investigators. Blood tissue, and DNA samples are archived and available to investigators. Fresh biological specimens also may be obtained.
Contact Information
Texas Biomedical Research Institute
Southwest National Primate Research Center
P. O. Box 760549
San Antonio, TX 78245-0549
Website: http://www.txbiomed.org/primate-research-center
Principal Investigator and Contact:
John L. VandeBerg, Ph.D.
Phone: 210-258-9430
Email: jlv@txbiomedgenetics.org
University of Texas
Research Emphasis/Objectives
Research objectives are to provide physically and behaviorally healthy chimpanzees for critical biomedical research and testing; to conduct relevant research projects of benefit to chimpanzee health, productivity, and well-being.
Current Research
Develop and improve techniques of captive management; investigate behavioral factors influencing improvements in the husbandry and well-being of chimpanzees; support collaborative programs in genetic management.
Services Provided
A demographically balanced group of approximately 100 physically and behaviorally healthy chimpanzees to meet current and future research and testing needs in the United States. The colony is housed in eight 4,500-square-foot outdoor corrals in multiple-male family groups. Complete facilities and services are available for visiting scientists. Chimpanzees are available to investigators supported by NIH grants and contracts.
Biological Materials
Tissues and body fluids are available when coordinated with preventive health care procedures.
Contact Information
University of Texas
M. D. Anderson Cancer Center
Department of Veterinary Sciences
650 Cool Water Drive
Bastrop, TX 78602
Website: http://mdanderson.org
Contact
William Satterfield, D.V.M.
512-321-3991; Fax: 512-332-5208
E-mail: wsatterf@mdanderson.org
Principal Investigator
Christian R. Abee, D.V.M.
Chimpanzee Management Program
Description
The NIH Chimpanzee Management Program (ChiMP) supports long-term, cost-effective housing and maintenance at ORIP-supported facilities for chimpanzees. ORIP provides programmatic oversight of the facilities and ensures they comply with the Animal Welfare Act, and policies concerning laboratory animal care and use. READ MORE >>
Contact Information
Office of Research Infrastructure Programs
Division Program Coordination, Planning, and Strategic Initiatives
Office of the Director
National Institutes of Health
One Democracy Plaza
6701 Democracy Boulevard, MSC 4874
Bethesda, Maryland 20892-4874
Contact
Harold Watson, Ph.D.
301-435-0744; Fax: 301-480-3819
E-mail: WatsonH@mail.nih.gov
Caribbean Primate Research Center SPF Rhesus Monkey Program
Research Emphasis/Objectives
Research objective are: i) to establish, and maintain, a specific-pathogen-free (SPF) rhesus macaque supply and breeding colony program and ii) to enhance the existing specific-pathogen-free (SPF) rhesus macaque supply and breeding colony program at the SabanaSeca Field Station of the Caribbean Primate Research Center (CPRC). The CPRC program will make a significant contribution to advancing AIDS research by providing high-quality and healthy SPF rhesus monkeys to NIH-sponsored research programs. The CPRC program uses genetically characterized, MHC-typed, Indian-origin monkeys from the CPRC's free-ranging colony on the island of Cayo Santiago. Previous surveys have shown that the Cayo Santiago macaques are free of several important viruses, including retroviruses and simian virus 40 (SV-40), and that the majority of immature animals are negative for B-virus (Herpesvirussimiae or Cercopithecineherpesvirus type 1). About 20-25 percent of these monkeys are also Mamu-A*01 positive. Currently, there is a shortage of SPF rhesus monkeys for biomedical research, and the demand for these animals is expected to increase dramatically in the future. The establishment and maintenance of this program at the SabanaSeca Field Station will help meet the increased demand for both SPF (B-virus, SRV-D, SIV, STLV-1, and SV-40-free) and Mamu-A*01 positive rhesus monkeys. Forty-five SPF females and nine SPF males (nine breeding groups) will be added to the colony each year through internal recruitment from Cayo Santiago and the SabanaSeca Field Station. MHC-typing and selective breeding will be used to increase the production of SPF Mamu-A*01 positive offspring.
Current Research
The virology laboratory conducts research on recombinant DNA vaccines using rhesus macaques and performs viral tests for herpes B-virus, STLV, and SIV. The BL 2/3 Virology Laboratory has allowed CPRC to establish the SPF program under the sponsorship of ORIP, and one of its major objectives is to support ongoing SPF programs. The laboratory serves as a platform of research in vaccine development (SHIV, SIV, Dengue) and in genetics. This laboratory provides services to the conventional and SPF CPRC colonies (viral serology/PCR) .With the support of R01 and U01 NIH grants, this laboratory is collaborating with mainland investigators in vaccine and pathogenesis studies involving rhesus macaques.
Services Provided
CPRC welcomes collaborative research with established behavioral and biomedical investigators and encourages the use of its animal and osteological resources for dissertation research. Investigators are charged modest use fees for access to the animals, computerized database, and office space. All proposals receive rigorous peer review and are judged on scientific merit, feasibility, and potential overlap with ongoing studies. Protocols using live monkeys must be approved by the Institutional Animal Care and Use Committee (IACUC) of the home institution, as well as the University of Puerto Rico Medical Sciences Campus IACUC.
Contact Information
University of Puerto Rico
Medical Sciences Campus
P.O. Box 1053
Sabana Seca, PR 00952-1053
Websites: http://cprc.rcm.upr.edu/
http://cprc.rcm.upr.edu/units/virologylab
Grant No.: U42 OD011128
Grant No.: U24 OD010421
Principal Investigator and Contact
U24OD10421- Carlos A. Sariol, MD (PI)
U42OD11128 - Carlos A. Sariol, MD (PI)
787-758-2525 ext. 5112 or ext. 1189; Fax: 787-767-1442
E-mail: carlos.sariol1@upr.edu
Mailing Address
Virology Laboratory
Office B-315
University of Puerto Rico School of Medicine
P.O. Box 365067
San Juan, PR 00936-5067
Establishment of a SPF Rhesus Macaque Colony in Texas
U42 OD 010442
Research Emphasis/Objectives
This project, which is located at the Southwest National Primate Research Center (SNPRC) in San Antonio, Texas, produces Indian-origin rhesus monkeys (Macaca mulatta) that are specific-pathogen-free (SPF) for herpes B virus, SIV, SRV, and STLV-1. The breeding colony produces high quality genetically characterized and MHC-typed animals for use in AIDS-related research conducted by NIH supported grantees. Occasionally, monkeys are available for other types of research or to non-NIH grantees.
Services Provided
Monkeys are available for sale to investigators who want to use the monkeys in research at the SNPRC and those who want to transport the monkeys for research conducted at other sites. ABSL-3 and ABSL-4 facilities are available at the SNPRC for infectious disease research, including research with Select Agents.
Contact Information
Texas Biomedical Research Institute
Southwest National Primate Research Center
P. O. Box 760549
San Antonio, TX 78245-0549
Website: http://www.txbiomed.org/primate-research-center
Principal Investigator and Contact:
John L. VandeBerg, Ph.D.
Phone: 210-258-9430
Email: jlv@txbiomedgenetics.org
Expansion of a SPF Rhesus Colony in Louisiana
Research Emphasis/Objectives
The objective of this grant is development and maintenance of a specific-pathogen-free (SPF) rhesus monkey (Macaca mulatta) breeding colony. Animals derived from the colony are limited to use for AIDS research. Nonhuman primates derived from the colony are seronegative for simian immunodeficiency virus (SIV), simian T -lymphotrophic virus (STLV-1), type D retrovirus (SRV), and Cercopithecineherpesvirus 1 (CHV1 or B-virus). The retroviruses (SIV, STLV-1 and SRV), when present in animals used for AIDS studies, may confound research data. B-virus is hazardous to humans and is being eliminated to protect personnel coming in contact with infected animals or their tissues.
Services Provided
SPF rhesus monkeys may be requested for AIDS research by contacting the principal investigator. The Tulane Resource Allocation Committee has responsibility for allocating animal resources to NIH-funded investigators. To apply for allocation of SPF rhesus monkeys, investigators must first complete an application form, which is available from the principal investigator.
Contact Information
Tulane National Primate Research Center
18703 Three Rivers Road
Covington, LA 70433
Grant No.: U24 OD011109
Principal Investigator
Rudolf P. Bohm, Jr., D.V.M.
985-671-6266; Fax: 985-871-6388
E-mail: TNPRC-VetMed@tulane.edu
Additional Contact
James L. Blanchard, D.V.M., Ph.D.
985-871-6285
E-mail: TNPRC-VetMed@tulane.edu
Production of Pedigreed SPF Rhesus Macaques in California
Research Emphasis/Objectives
The objective of this program is to produce pedigreed rhesus macaques of Indian origin that are free of selected viral pathogens. These agents include: Cercopithecine herpesvirus 1 (herpes B), simian immunodeficiency virus (SIV), simian T-lymphotropic virus 1, type D retrovirus, and simian foamy virus (SFV). These animals are of known pedigrees confirmed by microsatellite testing and are also typed for Mamu-A*01 alleles by the UC Davis Veterinary Genetics Laboratory. Colony status is confirmed by frequent viral screening through the Simian Retroviral Core Laboratory.
Current Research
Research programs are in place to use assisted reproductive technology strategies to expand numbers of Mamu-A*01 positive animals and other genotypes that may be of specific research interest. The center is also identifying additional viral pathogens to be excluded from the specific-pathogen-free (SPF) population. Genetic studies are under way to determine whether A*01 positive individuals are heterozygous or homozygous.
Services Provided
Animals
Scientists wishing to use pedigreed Indian origin rhesus macaques should contact the principal investigator. Scientists wishing to conduct research at the California National Primate Research Center should contact the director. Information for research access to the primate center is available on the center's website
Other Services
Pedigree analysis and MHC typing for rhesus macaque is available through the UC Davis Veterinary Genetics Laboratory.
Contact Information
California National Primate Research Center
University of California, Davis
One Shields Avenue
Davis, CA 95616-8542
Grant No.: U42 OD010990
Principal Investigator and Contact
Nicholas Lerche, D.V.M.
530-752-6490; Fax: 530-752-2880
E-mail: nwlerche@ucdavis.edu
Website: www.cNPRC.ucdavis.edu
SPF Indian Rhesus Monkey Colony in Louisiana
Research Emphasis/Objectives
The center's objective is development of a specific-pathogen-free (SPF) rhesus monkey ( Macaca mulatta ) breeding colony. Animals derived from the colony are limited to use for AIDS research. Nonhuman primates derived from the colony are seronegative for simian immunodeficiency virus (SIV), simian T-lymphotrophic virus (STLV-1), type D retrovirus (SRV), and Cercopithecine herpesvirus 1 (CHV1 or B-virus). The retroviruses (SIV, STLV-1, and SRV), when present in animals used for AIDS studies, may confound research data. B-virus is hazardous to humans and is being eliminated to protect personnel from coming in contact with infected animals or their tissues.
Services Provided
SPF rhesus monkeys may be requested for AIDS research by contacting the principal investigator. The Tulane Resource Allocation Committee has responsibility for allocating the animals to NIH-funded investigators. To apply for allocation of SPF rhesus monkeys must first complete an application form, which is available through the principal investigator.
Contact Information
Tulane National Primate Research Center
18703 Three Rivers Road
Covington, LA 70433
Grant No.: U42 OD010568
Principal Investigator
James L. Blanchard, D.V.M., Ph.D.
985-871-6285
E-mail: TNPRC-VetMed@tulane.edu
Additional Contact
Rudolf P. Bohm, Jr., D.V.M.
985-871-6266; Fax:985-871-6388
E-mail: TNPRC-VetMed@tulane.edu
Specific-Pathogen-Free Rhesus Monkeys in Oregon
Research Emphasis/Objectives
The ONPRC maintains a specific-pathogen-free (SPF) Indian-origin rhesus macaque breeding colony in support of AIDS-related biomedical research. The research objectives are to: maintain a breeding population sufficient to supply 100 NHPs for AIDS-related research annually; optimize the usefulness of this population for research by characterizing ancestry, parentage, and MHC type; and ensure the population remains SPF through state of the art surveillance technologies.
Current Research
The Center's SPF Indian-origin rhesus macaque breeding programs have target female breeder populations of 250 and 125 animals, respectively. All adults and juveniles are free of simian immunodeficiency virus, T-lymphotrophic virus 1, type D simian retroviruses, and Herpesvirussimiae. Frequent microbiologic monitoring is performed to ensure SPF status. Research objectives focus on maintaining pedigreed, genetically diverse female breeders and production of offspring with defined MHC class Ihaplotypes. Polymorphic microsatellite analyses are used to verify parentage, to select appropriate males, and to monitor genetic diversity in the colonies. The SPF definition is expanded in the U24-supported colony to include additional viral agents that are useful as models of opportunistic infections in AIDS research or as vectors for vaccine development such as cytomegalovirus, rhesus rhadinovirus, spumaretrovirus, and simian virus 40.
Services Provided
Animals
SPF juvenile Indian-origin rhesus macaques, are available for sale to NIH grantees and other qualifying investigators for AIDS-related research. Blood samples and other tissues and body fluids obtainable using routine, noninvasive clinical procedures are available to qualifying investigators with appropriate institutional approvals for research animal use. Cost estimates for collection, packaging, and shipping are available upon request. Allocation of animals produced under this cooperative agreement is determined by the ONPRC Animal UseCommittee in consultation with the NCRR program administrator to ensure equitable distribution.
Other Services
The Center's resources are available to collaborative NIH grantees with appropriate animal care and use (IACUC) approval and institutional contractual agreements. Resources include veterinary clinical services, biological safety level 3 laboratory and animal containment facilities, anatomic pathology, clinical pathology, microbiology, and flow cytometry. Further information is available from the Associate Director's office. Contact Charles Roberts, Ph.D., 503-690-5259, e-mail: robertsc@ohsu.edu
Contact Information
Oregon National Primate Research Center
Oregon Health Sciences University, West Campus
505 N.W. 185th Avenue
Beaverton, OR 97006-3499
Website: onprc.ohsu.edu
Grant No.:
U24 OD010850
Principal Investigator and Contact
Michael K. Axthelm, D.V.M.
503-690-5236; Fax: 503-690-5524
E-mail: axthelmm@ohsu.edu
U42 OD 010426
Principal Investigator and Contact
Cynthia J. Doane, D.V.M.
Fax: 503-614-3736
E-mail: doanec@ohsu.edu
P51 OD011092
Head, Non-Human Primate Resources, Division of Animal Resources
Kirk Andrews, D.V.M.
503-614-376; Fax: 503-614-3736
E-mail: andrekir@ohsu.edu
Washington M. nemestrina SPF Breeding Colony
Research Emphasis/Objectives
Nonhuman primate (NHP) species have proven to be invaluable resources for AIDS research in several fields, including vaccine development, therapeutic agent discovery, and pathogenesis. Well-defined models of AIDS currently exist in pigtailed macaques (M. nemestrina), utilizing a large number of primate lentiviruses and other infectious agents. SPF M. nemestrinaare an essential resource for the research community as it works to address these critical issues.
A critical need exists to increase the number of pigtailed macaques available to the national research community. The Center, works with partners both within and outside NIH, has embarked on a program to increase the size of it's M. nemestrina breeding colony over time, thereby increasing the supply of this resource to address important issues in research and medicine.
Current Research
Expand an M. nemestrina breeding colony free of Mycobacterium tuberculosis (TB); simian immunodeficiency virus; simian retrovirus, all subtypes; simian T-lymphoptrophic virus, and Cercopithecineherpesvirus 1 for application to AIDS-related NIH research projects.
Contact Information
Washington National Primate Research Center
University of Washington
Box 357330; Health Sciences Center, Room I-421
Seattle, WA 98195-7330
Website: http://www.wanprc.org/
Grant No.: U42 OD011123
Principal Investigator
David M. Anderson, D.V.M.
206-616-4583; Fax: 206-616-1710
E-mail: danderson@u.washington.edu
Expansion of a SPF Rhesus Colony in Georgia
Research Emphasis/Objectives
The Yerkes Center objective is to establishspecific-pathogen-free (SPF) rhesus monkey (Macacamulatta) breeding colony at its Field Station facilities. AIDS research. The animals derived from the colony are seronegative for simian immunodeficiency virus (SIV), simian T -lymphotrophic virus (STLV-1), type D retrovirus (SRV), and Cercopithecineherpesvirus 1 (CHV1 or B-virus). In addition, all animal are genetically characterized both in respect to pedigree information and selected MHC alleles. The nonhuman primates derived from this colony are available for AIDS-related studies by NIH grantees, and all of the above listed attributes are important for AIDS research.
Services Provided
SPF rhesus macaques may be requested for AIDS research by contacting the principal investigator. The Yerkes Resource Allocation Advisory Committee has responsibility for allocating animal resources to NIH-funded investigators. To apply for allocation of SPF rhesus monkeys, investigators must first complete an application form, which is available from the principal investigator.
Contact Information
Yerkes National Primate Research Center
Emory University
954 North Gatewood Road, NE
Atlanta, GA 30322
Grant No.: U24 OD011023
Principal Investigator
James G Else, DVM, MPVM
404-727-9710; Fax: 404-727-3756
E-mail: jelse@emory.edu
Additional Contact
Maria Crane, DVM
404-727-8653
E-mail: mmcrane@emory.edu
SFP Indian Rhesus Monkey Colony in New England
Research Emphasis/Objectives
The Simian Immunodeficiency Virus (SIV)-infected Indian-origin rhesus monkey (Macacamulatta) is the premiere animal model of human AIDS and has led to important advances in our understanding of disease pathogenesis, the role of viral determinants on disease progression, the impact of host immunity in controlling viral replication, and vaccine development. Rhesus macaques free of infection with Macacineherpesvirus 1 (B virus), Simian T lymphotropic Virus (STLV-1), Simian Retrovirus Type D (SRV-D), and SIV are essential to eliminate confounding variables associated with viral co-infections, to reduce the occupational health risks of working with macaques, and for overall colony health. The New England Primate Research Center (NEPRC) first established its specific-pathogen free (SPF) rhesus breeding colony in 1988, and the NEPRC SPF rhesus breeding colony is notable for its long history of i) high reproductive efficiency, ii) freedom from breaks in SPF status, and iii) providing animals for AIDS-related investigations.The goal of this project is to enhance the NEPRC SPF breeding colony production of well-characterized, SPF offspring for AIDS-related studies.
Services Provided
SPF rhesus monkeys may be requested for AIDS research by contacting the center. The NEPRC Procurement, Allocation, and Re-Use Committee has responsibility for allocating the animals to NIH-funded investigators. To apply for allocation of SPF rhesus monkeys must first complete an application form, which is available from the center.
Contact Information
New England Primate Research Center
1 Pine Hill Drive
Southborough, MA 01772
Grant No.: U42 OD010849
Center Director and Contact for Collaborative Research
Susan Westmoreland, VMD
508-624-8074
E-mail: susan_westmoreland@hms.harvard.edu
Additional Contact
Roger Spealman, Ph.D.
508-624-8037
E-mail: roger_spealman@hms.harvard.edu
Creation of a Nonhuman Embryo Gene Expression Resource
R24OD012221
Research Emphasis/Objectives
The Primate Embryo Gene Expression Resource (PREGER) contains a collection of nearly 200 amplified cDNA libraries from rhesus monkey oocytes and embryos representing a wide variety of experimental conditions. The purpose of PREGER is to provide interested investigators with access to molecular reagents needed for gene expression analysis in nonhuman primate embryos, at vastly reduced cost and labor.
Current Research
The resource is being expanded to incorporate samples of stem cells for studies related to stem cell biology. Determinants of oocyte quality are being sought through a novel suppression-subtraction hybridization method developed for application to the cDNA libraries contained in the resource.
Services Provided
The resource can produce and distribute amplified cDNA libraries in solution, phage libraries, dot blot hybridization membranes for gene expression analysis, primer sequences, and available human or rhesus monkey cDNA probes. The resource also houses an online searchable gene expression database, and a website containing methods, contacts, bibliography, and other tools. Registered users also receive a periodic newsletter about relevant advances in primate embryology. Collaborative arrangements in which gene expression patterns of specific genes are examined, or users contribute new experimentally manipulated samples that can then be analyzed in conjunction with a broader core set of samples, thereby reducing investigator expense, are also welcomed.
Contact Information
The Fels Institute for Cancer Research and Molecular Biology
Temple University School of Medicine
3307 North Broad Street
Philadelphia, PA 19140
Website: www.preger.org
Principal Investigator and Contact
Keith Latham, Ph.D.
215-707-7577; Fax: 215-707-1454
E-mail: klatham@temple.edu
Genetic Typing Laboratory
Research Emphasis/Objectives
Objectives of the laboratory are to: Identify and characterize previously unknown polymorphisms (including PCR-amplified mitochondrial DNA, Y-chromosome, and microsatellite DNA or STR loci); study the effectiveness of alternative genetic management strategies and the effect of demographic factors on the population/genetic structure of captive groups of primates; identify marker loci for genes that influence susceptibility to retroviral, B-virus, and other infections; and employ both ancient and contemporary mitochondrial DNA and microsatellite DNA loci for studies of ancestor-descendant relationships.
Services Provided
To Collaborating Scientists and Graduate Students
All principal investigators of NIH-supported specific-pathogen-free (SPF) breeding programs or their designees are eligible to request genetic marker analysis on rhesus macaques ( Macaca mulatta ), crab-eating macaques ( M. fascicularis ), pigtailed macaques ( M. nemestrina ), and other species of Macaca and Papio in SPF colonies; identify paternity; calculate kinship and inbreeding coefficients; determine country of origin; estimate parameters of genetic diversity, genetic subdivision, and founder representation within the colony; collaborate with principal investigators on colony management strategies and on research involving those data; and amplify and sequence noncoding control region of mitochondrial DNA extracted from modern and prehistoric (e.g., skeletal) material.
Contact Information
University of California, Davis
Department of Anthropology
209 Young Hall
Davis, CA 95616
Website: www.anthro.ucdavis
Principal Investigator
David Glenn Smith, Ph.D.
530-752-6343, 8570, or 6665; Fax: 530-752-8885
Message: 530-752-0745
E-mail: dgsmith@ucdavis.edu
Additional Contacts
John W. McDonough
530-752-8570
E-mail: jwmed@ucdavis.edu
Debra George
530-752-8570
E-mail: dageorge@ucdavis.edu
Gene-Targeted SNP discovery in rhesus macaques
Extension of R24 RR017444-09
Resource’s Research Emphasis and Objectives
This resource is focused on nonhuman primate genomics. Current work involves an improved sequence and assembly of the rhesus macaque genome and SNP discovery for this species. Past funding resulted in the Rhesus Macaque Genome Array for mRNA expression studies.
Services Provided:
Sequences, annotations and SNPs for the rhesus macaque. Further information can be found here:
http://www.unmc.edu/rhesusgenechip/
Contact Information
Rob Norgren (PI)
Phone: 402-559-8891
FAX: 402-559-7328
Email address: rnorgren@unmc.edu
Website: University of Nebraska Nonhuman Primate Genome Center (UN-NHPGC)
Website address: http://www.unmc.edu/rhesusgenechip/
Mail address:
University of Nebraska Medical Center
Department of Genetics, Cell Biology and Anatomy
985805 Nebraska Medical Center
Omaha, NE 68198-5805
NIH Nonhuman Primate Reagent Resource
Research Emphasis/Objectives
The objective of the NIH Nonhuman Primate Reagent Resource is to facilitate the use of nonhuman primate models of disease by providing reagents for targeting cell subsets or immune pathways in vivo. This is accomplished by developing new reagents specific for nonhuman primate proteins and by optimizing existing reagents for in vivo use in the nonhuman primate species.
Current Research
Current research is exploring the in vivo effectiveness of mouse/human, mouse/rhesus, fully-human and fully-rhesus recombinant monoclonal antibodies directed against cell targets. The goal is to develop reagents for administration to nonhuman primates that provide the optimal efficiency and duration of effect.
Services Provided
The resource provides antibodies for in vivo administration and for in vitro diagnostics in nonhuman primates. A database of commercial reagents that cross react with 12 different nonhuman primate species is maintained on the website. The resource also provides nonhuman primate recombinant proteins, reference reagents and cell lines.
Contact Information
Beth Israel Deaconess Medical Center
Division of Viral Pathogenesis
Center for Life Sciences 1038
3 Blackfan Circle
Boston, MA 02115
Website: http://NHPReagents.bidmc.harvard.edu
Principal Investigator
Keith A. Reimann, D.V.M.
617-735-4476; Fax: 617-735-4527
E-mail: kreimann@bidmc.harvard.edu
Additional Contact
Jodi A. Saia, M.Ed., Program Administrator
617-735-4459; Fax: 617-735-4527
E-mail: jsaia@bidmc.harvard.edu
Primate Genomics at the University of Washington
R24OD011157 and R24OD011172
Research Emphasis/Objectives
The center's objective is to develop the resources necessary to apply the technologies of functional genomics to nonhuman primate research. Central to this effort is the construction of macaque cDNA libraries, large-scale expressed sequence tag (EST) sequencing, and the production of macaque oligonucleotide microarrays.
Current Research
The resources being developed are tested in the context of integrated model systems, with particular emphasis on SIV infection of the rhesus macaque. The goal is to develop and make available physical and informational genomic resources to foster hypothesis-driven research using nonhuman primates and to increase understanding of a primary model for AIDS research.
Services Provided
cDNA libraries or clones from a variety of macaque tissues, macaque EST database, macaque oligonucleotide microarray.
Contact Information
Washington National Primate Research Center
University of Washington
Box 358070
Seattle, WA 98195-8070
Website: www.macaque.org
Principal Investigator
Michael G. Katze, Ph.D.
206-732-6136; Fax: 206-732-6056
E-mail: honey@u.washington.edu
Additional Contact
Shawn Iadonato, Ph.D.
206-378-0400; Fax: 206-378-0408
E-mail: siadonato@illumigen.com
Resource for Nonhuman Primate Immune Reagents
Research Emphasis/Objectives
Research objectives include characterizing, cloning, and quality testing nonhuman primate cytokines and immune cell-associated molecules in vitro and in vivo. Derivation of cytokines with extended bioavailability. This resource provides nonhuman primate immune reagents, such as cytokines, chemokines, soluble receptors as well as cDNA and expression clones for a variety of primate immune molecules. The website is: http://pathology.emory.edu/Villinger/index.htm
Current Research
Ongoing preparation of recombinant rhesus IL-2, IL-4, IL-7, IL-10, IL-12, IL-15, and Ig fusion cytokines. Custom preparation of cytokine- and cell-associated molecule expression vectors. Testing of adjuvant effect of defined immune enhancers in nonhuman primates. Cloning of new cytokines, receptors, and signaling molecules (IL-17, 21, 23, IL-7Ra, IL-15Ra, TIM3, FoxP3, etc.).
Services Provided
Distribution of nonhuman primate cytokine/immune molecule cDNAs for analysis and expression. Custom preparation of cytokine- and cell-associated molecule expression vectors. Custom preparation of recombinant cytokines. Custom cloning of new molecules from nonhuman primates. Expertise in cytokine analysis.
Contact Information
Department of Pathology and Laboratory Medicine
Emory University School of Medicine
1639 Pierce Drive, WMRB Room 2339
Atlanta, GA 30322
Website: pathology.emory.edu/Villinger/index.htm
Principal Investigator
François Villinger, D.V.M., Ph.D.
404-712-2838; Fax: 404-712-1771
E-mail: fvillin@emory.edu
Additional Contact
Chadi Filfili
404-712-1767; Fax: 404-712-1771
E-mail: rnhpir@emory.edu