Book

Guidelines and Recommendations

List of tables, figures, and boxes -- Abbreviations (in Guideline and Provider Supplement) -- Summary -- Introduction -- Evidence of need for additional HIV prevention methods -- Evidence of the safety and efficacy of antiretroviral prophylaxis -- Identifying indications for PrEP -- Providing PrEP -- Persons with documented HIV infection -- Discontinuing PrEP -- Special clinical considerations -- Improving medication adherence -- Reducing HIV risk behaviors -- Financial case-management issues for PrEP -- Decision support, training and technical assistance -- Related DHHS guidelines -- Appendix 1. HIV Test tables -- Appendix 2. Grading of strength of recommendations and quality of evidence -- Appendix 3. Participants in PrEP guidelines development and review -- References.

This document contains the 2014 U.S. Public Health Service Clinical Practice Guideline for Preexposure Prophylaxis for the Prevention of HIV Infection. The guideline is the first federal resource that provides comprehensive evidence-based information about the provision of daily oral antiretroviral preexposure prophylaxis (PrEP), including how to identify patients with indications for PrEP, guidance for safe prescribing practices, monitoring clinical safety for patients taking PrEP medications, and supporting medication adherence and the reduction of HIV risk behaviors. The guideline is intended for use by clinicians in the United States providing medical care for persons without HIV infection who are at substantial risk of acquiring it by their sexual or injection drug use behaviors. For these patients, the U.S. Public Health Service recommends offering PrEP as a prevention option.

For the Clinical Providers’ Supplement that accompanies this Clinical Practice Guideline, see Preexposure prophylaxis for the prevention of HIV infection – 2014 : clinical providers’ supplement.