Marshall W. Nirenberg Lecture
This lecture, established in 2011, recognizes Marshall Nirenberg for his work to decipher the genetic code, which resulted in his receiving the 1968 Nobel Prize in Physiology or Medicine. Nirenberg’s research career at the NIH spanned more than 50 years, and his research also focused on neuroscience, neural development, and the homeobox genes. The Nirenberg lecture recognizes outstanding contributions to genetics and molecular biology.
Lecture Title Forthcoming
The information for this lecture has not yet been made available. Please check back soon for an updated overview.
The AML genome(s): Mutations in four dimensions
For many years, Dr. Ley's laboratory has used mouse models of acute myeloid leukemia (AML) to establish key principles of AML pathogenesis. The lab established that the initiating event for Acute Promyelocytic Leukemia is the PML-RARA fusion gene created by the t(15;17) that is found in nearly all patients with this disease. The roles of cooperating mutations and the cellular milieu for APL pathogenesis have also been established.
Lost in Translation: Do males and females read their genomes differently?
Dr. Page's laboratory seeks to understand fundamental differences between males and females in health and disease, both within and beyond the reproductive tract. Most recently, the Page lab discovered that XY and XX sex chromosomes account for subtle differences in the molecular biology of male and female cells and tissues throughout the body. These findings emerged from the lab’s comparative genomic and evolutionary studies of the sex chromosomes of humans, other mammals, and birds.
Optical deconstruction of fully-assembled biological systems
Dr. Deisseroth’s lecture will report on the development of optogenetics and CLARITY technologies. In the optogenetics domain, he will discuss strategies for targeting microbial opsins and light to meet the challenging constraints of the freely-behaving mammal, newly engineered microbial opsin genes spanning a range of optical, kinetic, and ion permeability properties, high-speed behavioral and neural activity-readout tools compatible with real-time optogenetic control, and the application of these tools to develop circuit-based insights into anxiety, depression, and motivated behaviors.
The page was last updated on Thursday, January 29, 2015 - 2:28pm
