Oral Human Papillomavirus Infection in HIV-Infected Men
Recruitment status was Recruiting
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Human papillomavirus (HPV)-infection belong to the most common sexually transmitted diseases worldwide. HIV-infected men having sex with men /MSM) are strongly associated with a higher prevalence of genitoanal HPV-infection, and perianal HPV-infections have been detected in up to 90% of HIV-positive men. The data concerning the incidence of oral HPV-infection in HIV-positive men, especially in the era of highly antiretroviral therapy, are conflicting. Thus, this prospective study mainly focuses on the incidence and prevalence of oral HPV-infection, spectrum of HPV-types, and oral high-risk HPV viral load in HIV-positive men.
Condition | Intervention |
---|---|
Papillomavirus Infections HIV Infections |
Procedure: Oral swabs for HPV-typing and high-risk HPV-determination |
Study Type: | Observational |
Study Design: | Observational Model: Case Control Time Perspective: Prospective |
Official Title: | Incidence, Prevalence, Spectrum of HPV-Types, and Viral Load Determination of High-Risk Human Papillomavirus Infection of the Oral Cavity in HIV-Infected Men Who Have Sex With Men |
Estimated Enrollment: | 500 |
Study Start Date: | March 2006 |
Estimated Study Completion Date: | April 2010 |
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Procedure: Oral swabs for HPV-typing and high-risk HPV-determination
Human papillomavirus (HPV)-infection belong to the most common sexually transmitted diseases worldwide. Estimated prevalences of subclinical genital HPV-infection in the immunocompetent sexually active population range from 10 to above 50%. Genetic or iatrogenic immunosuppression is known to play a decisive role in the initiation of a variety of cutaneous neoplasias and their precursor lesions. In this context, HPV-associated anogenital malignancies occur with high frequency in patients with HIV-infection. In several studies, perianal HPV-infections have been detected in up to 90% of HIV-positive men and a high incidence of anal dysplasia has been reported in these patients. The data concerning the incidence of oral HPV-infection in HIV-positive men, especially in the era of highly antiretroviral therapy, are conflicting. Thus, this prospective study mainly focuses on the incidence and prevalence of oral HPV-infection, spectrum of HPV-types, and oral high-risk HPV viral load in HIV-positive men.
![](https://webarchive.library.unt.edu/web/20130228141054im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
HIV-infected men who have sex with men
Inclusion Criteria:
- HIV-infected men who have sex with men
Exclusion Criteria:
- None
![](https://webarchive.library.unt.edu/web/20130228141054im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
Contact: Alexander Kreuter, MD | 0049/234/5093439 | a.kreuter@derma.de |
Germany | |
Department of Dermatology, Ruhr University Bochum | Recruiting |
Bochum, NRW, Germany, 44791 | |
Contact: Alexander Kreuter, MD 0049/234/5093439 a.kreuter@derma.de | |
Principal Investigator: Alexander Kreuter, MD | |
Principal Investigator: Norbert Brockmeyer, MD | |
Institute of Virology, University of Cologne | Recruiting |
Köln, NRW, Germany, 50935 | |
Contact: Ulrike Wieland, MD | |
Principal Investigator: Ulrike Wieland, MD |
Principal Investigator: | Alexander Kreuter, MD | Department of Dermatology, Ruhr University Bochum |
Principal Investigator: | Norbert Brockmeyer, MD | Department of Dermatology, Ruhr University Bochum |
Principal Investigator: | Ulrike Wieland, MD | Institute of Virology, University of Cologne |
![](https://webarchive.library.unt.edu/web/20130228141054im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
Additional Information:
No publications provided
Responsible Party: | Kompetenznetz HIV/AIDS, BMBF |
ClinicalTrials.gov Identifier: | NCT00421486 History of Changes |
Other Study ID Numbers: | 01 KI 0501 |
Study First Received: | January 10, 2007 |
Last Updated: | January 16, 2009 |
Health Authority: | Germany: Ethics Commission |
Keywords provided by Deutsche Luft und Raumfahrt:
Oral human papillomavirus infection HIV-infection High-risk HPV viral load |
Oral human papillomavirus infection in HIV-positive men Treatment Experienced Treatment Naive |
Additional relevant MeSH terms:
HIV Infections Acquired Immunodeficiency Syndrome Warts Papillomavirus Infections Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases |
Immunologic Deficiency Syndromes Immune System Diseases Slow Virus Diseases DNA Virus Infections Skin Diseases, Viral Tumor Virus Infections Neoplasms Skin Diseases, Infectious Skin Diseases |
ClinicalTrials.gov processed this record on February 26, 2013