Understanding the Functions of Uncharacterized Genes in Infectious Disease Pathogens
What services does this resource provide?
The Functional Genomics Program for understanding the functions of uncharacterized genes in infectious disease pathogens aims to generate experimental data to determine the biochemical function(s) of hypothetical genes, unknown open reading frames, and noncoding RNAs.
The program applies state-of-the-art technologies to determine the biochemical and physiological roles of these gene components. Obtaining a more comprehensive understanding of uncharacterized genes in infectious disease pathogens will lead to improved genomic annotation and allow for the development of potential new targets for medical diagnostics, therapeutics and vaccines.
The program distributes data, software, and reagents generated from the research projects to the broader scientific community.
Where are services provided?
The research activities are carried out by
- Harvard University School of Public Health - Functionalizing Lists of Unknown TB Entities (FLUTE)
- Project description (NIH RePORTER)
- University of Chicago – Chicago Center for Functional Annotation (CCFA)
- Project description (NIH RePORTER)
- University of North Carolina at Chapel Hill (Orfeome)
- Project description (NIH RePORTER)
- University of Washington - Genes Unknown in Acinetobacter baumannii (GUnk)
- Project description (NIH RePORTER)
Access
Program-generated data and software are made available through publicly accessible Web and database sites, including the NIAID Bioinformatic Resource Centers.
Reagents may be obtained from the program participants listed above.
Information and Related Resources
- News and Announcements
- A multipronged investigation to define a blueprint for systematic functional analysis of pathogens
- Data Sharing and Release Guidelines
- Steering Committee
- Related NIAID-Supported Services