Johns Hopkins University students in a laboratory.Johns Hopkins University

Two of the cornerstones of science advancement are rigor in designing and performing scientific research and the ability to reproduce biomedical research findings. The application of rigor ensures robust and unbiased experimental design, methodology, analysis, interpretation, and reporting of results. When a result can be reproduced by multiple scientists, it validates the original results and readiness to progress to the next phase of research. This is especially important for clinical trials in humans, which are built on studies that have demonstrated a particular effect or outcome.

In recent years, however, there has been a growing awareness of the need for rigorously designed published preclinical studies, to ensure that such studies can be reproduced. This webpage provides information about the efforts underway by NIH to enhance rigor and reproducibility in scientific research.

Richard Siegel, M.D., Ph.D., (right) NIAMS Clinical Director and Chief of the Autoimmunity Branch, discusses research results with postdoctoral fellow Martin Pelletier, Ph.D.Bill Branson