ACYF's senior leadership role is nominated by the President and confirmed by the United States Senate. Elizabeth Darling currently serves as the Commissioner of the Administration on Children, Youth and Families (ACYF).
ACYF is divided into two bureaus responsible for different issues involving children, youth and families and a crosscutting unit charged with research and evaluation. Each bureau has an associate commissioner appointed by the President.
In addition, the United States and its territories are divided into 10 regions, each having an office responsible for ACYF programs located in that region.