Research on Childhood Cancers
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New Mouse Model Closely Mimics Most Common Leukemia in InfantsPosted: December 30, 2016
Researchers have created a long-sought-after mouse model for an aggressive form of acute lymphoblastic leukemia that occurs commonly in infants and that the researchers believe can accelerate the development of new therapies for the disease.
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Early-phase trial demonstrates shrinkage in pediatric neural tumorsPosted: December 28, 2016
In an early-phase clinical trial of a new oral drug, selumetinib, children with the common genetic disorder neurofibromatosis type 1 (NF1) and plexiform neurofibromas, tumors of the peripheral nerves, tolerated selumetinib and, in most cases, responded to it with tumor shrinkage.
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TARGET Initiative Fueling Progress Against Childhood LeukemiaPosted: September 30, 2016
Research from TARGET, an NCI-funded program supporting genomic analyses of childhood cancers, has led to the launch of several clinical trials of targeted therapies to treat children with acute lymphoblastic leukemia.
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The Impact and Future of the Childhood Cancer Survivor Study: An Interview with Greg Armstrong, M.D.Posted: September 14, 2016
Dr. Greg Armstrong of the Childhood Cancer Survivor Study discusses this long-running study and its future.
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Toward Precision Therapy for Children with Cancer: An Interview with Dr. Javed KhanPosted: April 13, 2016
NCI’s Dr. Javed Khan discusses a new NCI clinical program and the promise and challenges of genome-guided therapy for children with cancer.
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Gene Fusion May Drive Rare Childhood Brain TumorPosted: February 22, 2016
Researchers have identified a genetic rearrangement that may drive the development of a rare benign brain tumor in children through three distinct biological mechanisms simultaneously.
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New Drug for Pediatric Neuroblastoma Shows Promise in Preclinical StudiesPosted: December 17, 2015
An international research team has identified a possible new treatment target for pediatric neuroblastoma and is planning an early-stage clinical trial of a drug that inhibits this target.
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Study Sheds Light on Role of Inherited Mutations in Childhood CancerPosted: December 8, 2015
In the most comprehensive study of its kind conducted to date, more than 8 percent of children with cancer were found to have inherited genetic mutations associated with a predisposition to the disease.
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For Some Children with Cancer, Genomic Information May Help Guide Treatment DecisionsPosted: September 18, 2015
Genomic methods, such as DNA sequencing, may help doctors manage the treatment of children and young adults with cancer.
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NCI Initiative to Speed Development of Childhood Cancer TherapiesPosted: September 8, 2015
NCI has awarded grants to five research teams to participate in its Pediatric Preclinical Testing Consortium, which is intended to help to prioritize which agents to pursue in pediatric clinical trials.
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Cancer Risk in Childhood Cancer Survivors Continues for DecadesPosted: August 31, 2015
Survivors of childhood cancer have an elevated risk of developing second, distinct cancers into their forties and beyond, according to a new study.
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Childhood Cancer Genomics Gaps and Opportunities: Identification of Research Priorities Workshop SummaryPosted: July 17, 2015
NCI convened a workshop of representative research teams that have been leaders in defining the genomic landscape of childhood cancers to discuss the influence of genomic discoveries on the future of childhood cancer research.
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Better Care for Children with Cancer Linked to Longer LifespansPosted: June 11, 2015
New data from the Childhood Cancer Survivor Study suggest that refinements in pediatric cancer treatment over the last few decades have helped to extend the lifespans of many survivors of childhood cancer.
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Treatment Prevents Chemotherapy Side Effects for Children with CancerPosted: May 13, 2015
Final results from a phase III randomized clinical trial show that addition of aprepitant to the anti-nausea drug ondansetron, with or without dexamethasone, effectively prevents chemotherapy-induced nausea and vomiting in pediatric patients.
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Childhood Cancer Survivor Study: An OverviewUpdated: August 31, 2016
Health problems that develop years later as a result of a cancer treatment are known as late effects. The Childhood Cancer Survivor Study (CCSS) was started in 1994 to better understand and address these late effects.
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Looking to the Future of Childhood Cancer ResearchPosted: March 31, 2015
NCI’s Dr. Malcolm Smith discusses future directions of childhood cancer research, including treatment directions and clinical trials.
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Genetic Studies Yield Clues to Treatment-Related Side Effects in Children with CancerPosted: February 26, 2015
Researchers have identified genetic variations in children with brain cancer that increased their risk of rapid hearing loss after treatment.
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Study Finds Small Increase in Cancer Risk after Childhood CT ScansPosted: July 10, 2012
A study published in the June 6, 2012, issue of The Lancet shows that radiation exposure from computed tomography (CT) scans in childhood results in very small but increased risks of leukemia and brain tumors in the first decade after exposure.
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More Chemotherapy May Help after Initial Treatment for Childhood Leukemia FailsPosted: June 7, 2012
A study suggests that at least some children diagnosed with acute lymphoblastic leukemia who respond poorly to initial chemotherapy may do better if they receive additional chemotherapy rather than a stem cell transplant.
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Lenalidomide and Radiation for Children with Brain CancersPosted: May 17, 2011
In this trial, patients up to age 18 who are newly diagnosed with diffuse intrinsic pontine gliomas (DIPG) or who have other high-grade gliomas that could not be completely resected will undergo radiation therapy and receive oral lenalidomide at increasing doses daily for 6 weeks, followed by lenalidomide alone.
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International Childhood Cancer Cohort Consortium
An alliance of several large-scale prospective cohort studies of children to pool data and biospecimens and study various modifiable and genetic factors in relation to cancer risk.