National Toxicology Program

Webinar Series

Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish

Webinar 2: Ontologies 101
February 16, 2017 — 11:30 a.m.-12:30 p.m. Eastern Time

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If you registered to view Webinar 1, you are already registered to view Webinars 2 and 3.

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The small size and rapid development of the zebrafish make it a useful vertebrate model for assessing potential effects of chemicals on development in a medium to high-throughput manner. However, a lack of harmonization in several key protocol components hinders the broader adoption of the zebrafish model for toxicological screening. In an effort to address this issue, NTP launched the Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) program.

SEAZIT is addressing the issues of variability among laboratories in the endpoints measured, as well as the nomenclature used for each endpoint. NICEATM is organizing a webinar series in support of the SEAZIT program that will consider how these issues might be addressed by implementation of standardized nomenclature systems, also known as ontologies.

• Webinar 1 (February 2): Introduction to Zebrafish Screening
  This webinar provided an overview of the SEAZIT program and reviewed the variability found in zebrafish screening data.
  Speakers:
  • Nigel Walker, Ph.D., Deputy Division Director for Research, National Toxicology Program
    Presentation: An Overview of SEAZIT
  • David Reif, Ph.D., Associate Professor, Bioinformatics Research Center and Center for Human Health and the Environment, Department of Biological Sciences, North Carolina State University
    Presentation: Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish
  • Jon Hamm, Ph.D., Senior Staff Toxicologist, Integrated Laboratory Systems, Inc.
    Presentation: SEAZIT: Current and Proposed Activities
• Webinar 2 (February 16): Ontologies 101
  This webinar will define ontologies and describe how they are employed to improve data analysis.
  Speaker: Lyle Burgoon, Ph.D., Leader, Bioinformatics and Computational Toxicology Group, U.S. Army Engineer Research and Development Center
• Webinar 3 (March 2): A Review of Relevant Ontologies and Application of Reasoners
  This webinar will provide information on relevant zebrafish, phenotype, and anatomy ontologies and provide an example of the application of ontologies and reasoners.
  Speaker: Melissa Haendel, Ph.D., Director, Ontology Development Group, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University

All webinars will begin at 11:30 a.m. Eastern Standard Time.

The webinars are free and open to the public, but registration is required to attend. Registration for any webinar will automatically register the participant for all subsequent webinars. Additional details about the webinars will be posted on this page when available.

View Federal Register notice announcing webinar series (December 29, 2016) – View notice as webpage

Individuals with disabilities who need accommodation to participate in this event should email Elizabeth Maull or contact her at telephone: (919) 316–4668. TTY users should contact the Federal TTY Relay Service at (800) 877–8339. Requests should be made at least five business days in advance of the event.