Latest Summaries
Hyponatremia in Older Patients Who Begin Second-Generation AntidepressantsFree
- Allan S. Brett, MD
Excess risk for hyponatremia at 30 days was small but statistically significant.
VTE Induced by Podoplanin in Patients with Primary Brain Tumors
- David Green, MD, PhD
Risk for venous thromboembolism rose as podoplanin expression increased.
Is Cardiovascular Disease in COPD Patients Affected by Which Long-Acting Bronchodilator Is Used?
- David J. Amrol, MD
β-agonists and antimuscarinic agents confer similar CV risk in patients with chronic obstructive pulmonary disease.
- Candida auris Emerging Worldwide, Multidrug Resistant, and Lethal
- Stephen G. Baum, MD
A yeast not identified before 2009 has emerged on several continents almost simultaneously and carries a high mortality.
Late-Life Depression, Venlafaxine Response, and Genetic Variants
- Joel Yager, MD
A polymorphism on a norepinephrine transporter gene is associated with remission, earlier response, and greater change in symptoms.
More Bad News About Obesity
- Barbara Geller, MD
In an epigenome-wide association study, higher weight was linked to methylation of loci on genes that predict weight gain and involve lipid and inflammation pathways.
Self-Reliance and Suicidality in Men
- Joel Yager, MD
In an epidemiological study of Australian men, self-reliance was the only marker of “dominant masculinity” associated with suicidal thinking.
Less-Frequent Intravenous Zoledronic Acid for Patients with Skeletal Metastases
- Michael R. McClung, MD, FACP, FACE
Study shows interdose interval can be extended from 4 weeks to 12 weeks without compromising efficacy at preventing skeletal-related events.
HBV Reactivation in Patients with Isolated HBcAb Positivity Undergoing Stem Cell Transplant
- Atif Zaman, MD, MPH
High rates of hepatitis B virus reactivation underscore the importance of close patient monitoring.
Microbial Translocation and Gut Inflammation Inhibits Control of Acute SIV Replication
- Keith Henry, MD
Within days after acute SIV infection of macaques, plasma levels of microbial DNA increased significantly, perhaps crippling the host's ability to contain the infection.
Few Trauma Patients Meeting Guideline Criteria for Transfer Are Transferred
- Daniel M. Lindberg, MD
Patient and hospital factors associated with nontransfer include commercial insurance status and more resources.
Use of Direct-Acting Oral Anticoagulants in the Real World
- Joel M. Gore, MD
Analysis of registry data reveals that many patients are not receiving the recommended doses — and the recommended care.
Elevated Lactate in Children with Suspected Infection Confers Increased Mortality Risk
- Katherine Bakes, MD
Children with lactate levels >36 mg/dL (4.0 mmol/L) had a threefold increase in odds of 30-day mortality.
How Soon Can Patients with New Stents Undergo Surgery?
- Joel M. Gore, MD
A study of Danish registry data suggests that a delay of a year may be unnecessary.
Risks for GI Bleeding with Direct Oral Anticoagulants
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
Risks were lower with apixaban than with dabigatran or rivaroxaban.
Lacosamide vs. Controlled-Release Carbamazepine Monotherapy as Initial Epilepsy Treatment
- Robert C. Knowlton, MD, MSPH
Lacosamide was no less effective for new-onset seizures in patients with clinically suspected partial epilepsy.
Racial and Ethnic Disparities in Gastric Cancer Risk
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
Black non-Hispanic, Hispanic, and Asian/Pacific Islander people had a 40% to 50% higher risk for gastric cancer than white people in a regional U.S. population.
Emergency Department Visits for Adverse Drug Events Remain High
- Daniel D. Dressler, MD, MSc, SFHM, FACP
In older adults, antithrombotic drugs, antidiabetes drugs, and opioids accounted for three fourths of these visits.
Recurrent Throat Infections in Children: Surgery or Watchful Waiting?Free
- Deborah Lehman, MD
A systematic review finds that tonsillectomy provides some short-term benefits over watchful waiting for children with mild to moderate throat infections, but it's not clear if the benefits persist.
A Blood Test for Variant Creutzfeldt-Jakob Disease?
- Rajesh T. Gandhi, MD
Two small studies find that the prions can be detected in blood.
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NEJM Open Forum discussion
NEJM Open Forum discussion of Journal Watch General Medicine Year in Review 2016 Free
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