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Current Issue December 2016

01/09/2017

RESEARCH ARTICLE

Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegans

Lin Wang, Zhiyu Liu and colleagues identified a highly conserved ADAM protein, SUP-17/ADAM10, as an important factor in modulating BMP signaling in C. elegans and showed that proper localization and function of this ADAM protease require two conserved tetraspanin proteins, TSP-12 and TSP-14.

Image credit: Lin Wang, Zhiyu Liu and colleagues

Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegans

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