The increased risk of a terrorist attack in the United States involving chemical agents has created new challenges for many departments and agencies across the federal government. Within the U.S. Department of Health and Human Services (HHS), the NIH is taking a leadership role in pursuing the development of new and improved medical countermeasures designed to prevent, diagnose, and/or treat the conditions caused by potential and existing chemical threat agents. Many of these same chemicals not only pose as a terrorist threat agent, they may also be released from transportation and storage facilities during industrial accidents or natural disasters. The overarching goal of the CounterACT program is to integrate cutting-edge research with the latest technological advances in science and medicine for a more rapid and effective response during these chemical emergencies.
The CounterACT program is a translational research program supporting basic, translational, and clinical research aimed at the discovery or identification of better therapeutic medical countermeasures and/or diagnostic technologies against chemical threat agents, and facilitates their movement through the drug development and regulatory processes in collaboration with other federal departments, agencies, and initiatives, such as the Biomedical Advanced Research and Development Authority (HHS BARDA) and the FDA Medical Countermeasures Initiative (MCMi). CounterACT is part of the HHS Public Health Emergency Medical Countermeasures Enterprise (PHEMCE), which coordinates MCM-related efforts across HHS and USG interagency partners.This NIH-led program includes a comprehensive network of Research Centers of Excellence, individual co-operative research projects, small business innovation research grants, contracts, and interagency agreements with the Department of Defense.
The CounterACT program is funded by a special Congressional supplement to the NIH budget through the Office of the Director (NIH OD) under the oversight of the Office of Biodefense Research at the NIAID. This is a trans-NIH effort, involving partnerships with the NEI, NIAID, NIAMS, NICHD, NIEHS, NLM, NHLBI, and NINDS to execute the overall NIH Medical Research Program Directed Against Chemical Threats.
Special consideration will be given to research relevant to people who are particularly vulnerable, including pregnant women, infants, the young, the elderly, and individuals with pre-existing medical conditions. Animal models and studies that address these vulnerabilities as well as long term effects after an acute exposure event are of interest. An animal model is defined as a specific combination of an animal species, challenge agent, and route of exposure that produces a disease process or pathological condition that in multiple important aspects corresponds to the human disease or condition of interest.
David A. Jett, Ph.D.
Director, CounterACT
National Institutes of Health, NINDS
301.496.6035
jettd@ninds.nih.gov
D. Yeung, Ph.D.
Project Manager, CounterACT
National Institutes of Health, NINDS
301.443.7534
dy70v@nih.gov
Gennady E. Platoff Jr., Ph.D.
Biodefense Research Countermeasures
Office of Biodefense Research & Surety
National Institutes of Health, NIAID
301.451.4416
platoffg@niaid.nih.gov
Shardell M. Spriggs, Ph.D.
Health Program Specialist, CounterACT
National Institutes of Health, NINDS
301.443.8189
shardell.spriggs@nih.gov
Renee Waltzer [C]
Operations Coordinator, CounterACT
National Institutes of Health, NINDS
301.496.6425
renee.waltzer@nih.gov
Houmam Araj, Ph.D.
Program Director, Vision Research Program
National Institutes of Health, NEI
301.451.2020
arajh@nei.nih.gov
Pertti (Bert) J. Hakkinen, Ph.D.
Acting Head, Office of Clinical Toxicology, and
Senior Toxicologist, and Toxicology and Environmental
Health Science Advisor (to the Director) Specialized Information Services
National Institutes of Health, NLM
301.827.4222
pertti.hakkinen@nih.gov
Andrea L. Harabin, Ph.D.
Program Director, Acute Lung Injury and Critical Care
National Institutes of Health, NHLBI
301.435.0222
harabina@nhlbi.nih.gov
Elizabeth Maull, Ph.D.
Toxicologist, Biomolecular Screening Branch
National Institutes of Health, NIEHS, NTP
919.316.4668
maull@niehs.nih.gov
Srikanth S. Nadadur, Ph.D.
Health Scientist Administrator, Cardiovascular Health
National Institutes of Health, NIEHS
919.541.5327
nadadurs@niehs.nih.gov
David Siegel, M.D., F.A.A.P.
Medical Officer, Obstetric & Pediatric Pharmacology Branch
National Institutes of Health, NICHD
siegelda@mail.nih.gov
Randall Stewart, Ph.D.
Program Director, Channels, Synapses, and Circuits
National Institutes of Health, NINDS
301.496.1917
stewartr1@mail.nih.gov
Hung Tseng, Ph.D.
Health Scientist Administrator, Div. of Skin and Rheumatic Diseases
National Institutes of Health, NIAMS
301.594.5032
tsengh@mail.nih.gov
CounterACT Application Examples (U01 and U54): Milestones
CounterACT Efficacy Research Facility (CERF)
CounterACT Preclinical Development Facility (CPDF)
CounterACT Neurotherapeutics Screening (CNS) Program
NIH Molecular Libraries Program: Pathways to Discovery
Related publications
Researchers and Projects
Meetings & Workshops
2015
2014