Computational Toxicology Communities of Practice
EPA's Computational Toxicology Communities of Practice is composed of hundreds of stakeholders from over 50 public and private sector organizations (ranging from EPA, other federal agencies, industry, academic institutions, professional societies, nongovernmental organizations, environmental non-profit groups, state environmental agencies and more) who have an interest in using advances in computational toxicology and exposure science to evaluate the safety of chemicals.
The Communities of Practice is open to the public. Monthly webinars are held at EPA's RTP campus, on the fourth Thursday of the month (occasionally rescheduled in November and December to accommodate holiday schedules), from 11am-Noon EST/EDT. Remote participation is available. For more information or to be added to the meeting email list, contact: Monica Linnenbrink (linnenbrink.monica@epa.gov).
Past Webinar Presentations
Presentation File | Presented By | Date |
---|---|---|
Richard Judson, EPA's National Center for Computational Toxicology (NCCT) | 2016/11/17 | |
Evaluating the Zebrafish Embryo Toxicity Test for Pesticide Hazard Screening (Video) | Scott Glaberman, Assitant Professor, Department of Biology, University of South Alabama Stephanie Padilla, Branch Chief and Senior Scientist, Genetics and Cellular Toxicology Branch, Integrated Toxicology Division |
2016/10/27 |
Food-Use Chemicals in ToxCast: Identification, Curation, and Evaluation(25 pp, 1 MB) (Video) | Agnes Karmaus, Integrated Laboratory Systems Inc. Contractor supporting the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) | 2016/9/22 |
Adverse Outcome Pathway Knowledge Base(57 pp, 6 MB) (Video) | Stephen Edwards, EPA's National Health and Environmental Effects Research Laboratory (NHEERL) | 2016/8/25 |
Non-Targeted Screening Research(48 pp, 25 MB) (Video) | Jon Sobus, EPA's National Exposure Research Laboratory | 2016/7/28 |
An Introduction to the iCSS Chemistry Dashboard (Video) | Antony Williams and Kamel Mansouri, EPA’s National Center for Computational Toxicology | 2016/5/26 |
Using MEAs to screen chemicals for potential neurotoxicity and developmental neurotoxicity (Video) | Timothy Shafer, EPA’s National Health and Environmental Effects Research Laboratory | 2016/4/28 |
ToxCast Profiling in a Human Stem Cell Assay for Developmental Toxicity | Tom Knudsen, National Center for Computational Toxicology | 2016/3/24 |
Analysis of High-throughput screening data from Amplex UltraRed (AUR) Thyroperoxidase (TPO) assays | Katie Paul Friedman, Bayer Crop Science Toxicologist & Eric Watt, ORISE Postdoc Fellow for US EPA National Center for Computational Toxicology | 2016/2/25 |
High-throughput screening of chemical effects on steroidogenesis using H295R cells and demonstration of how to find the data using the iCSS Dashboard | Agnes L. Karmaus, Ph.D. ORISE Postdoctoral Research Fellow for NCCT | 2016/1/28 |
The High-Throughput Toxicokinetic (HTTK) R package (Video) | John Wambaugh, Ph.D., EPA, National Center for Computational Toxicology | 2015/12/10 |
Toxicological tipping points- distinguishing between adaptive responses and those that result in adverse health and environmental outcomes (Video) | Imran Shah, Ph.D., EPA, National Center for Computational Toxicology | 2015/11/12 |
Mechanisms of acute toxicity and using ToxCast data to predict acute toxicity(72 pp, 14 MB) (Video) | Daniel Wilson, Ph.D., DABT, Science Leader at Toxicology and Environmental Research and Consulting, The Dow Chemical Company | 2015/10/22 |
Overview of the Collaborative Estrogen Receptor Activity Prediction Project (CERAPP) | Kamel Mansouri, PhD, ORISE Post-Doc at US EPA | 2015/09/24 |
Overview and Demo of the New iCSS Dashboard (Video) | Matt Martin, PhD, US EPA ORD, NCCT | 2015/08/24 |
Introducing a budding consortium focused on using alternative species for chemicals testing (Video) | John Colbourne, Ph.D., from the University of Birmingham | 2015/07/23 |
A Systems Biology Approach to Environmental Biology (also view Video) | Philipp Antczak, Ph.D. University of Liverpool | 2015/06/25 |
Using the Library of Integrated Network-Based Cellular Signatures (LINCS) to Characterize the Mechanism of Action of Small-Molecule Therapeutics (also view Video) | Aravind Subramanian, Ph.D. The Broad Institute of MIT and Harvard | 2015/05/28 |
An overview of EPA’s Endocrine Disruption Screening Program’s plans for using biological activity data identified through high-throughput screening combined with high-throughput exposure estimates to prioritize chemicals for estrogen-related activity (also view Video) | Patience Brown, presenting for David Dix, EPA | 2015/04/23 |
EPA’s Society of Toxicology Annual Meeting Participation | Monica Linnenbrink, Christina Baghdikian, and Intaek Hahn, EPA | 2015/03/19 |
Exploring the Potential Utility of High-throughput Bioassays Associated with U.S. EPA ToxCast Program for Effects-based Monitoring and Surveillance (also view Video) | Anthony Schroeder, Postdoctoral Associate, National Health and Environmental Effects Research Laboratory, EPA | 2015/01/22 |
Highlights of the New ToxCast Data Pipeline | Filer, Dayne ORISE Fellow and Richard Judson PhD, US EPA Office of Research and Development (ORD), National Center for Computational Toxicology (NCCT) | 2014/12/11 |
Updates about EPA’s High-Throughput Exposure Prediction Research (ExpoCast) Project (also view Video) | Wambaugh, John, PhD, US EPA ORD, NCCT | 2014/11/20 |
Bioactivity profiling using primary human cell systems in support of predictive toxicology (also view Video) | Houck, Keith, PhD, US EPA ORD, NCCT | 2014/10/23 |
An Interspecies Comparison of Toxicity Pathways Mediating Neurodevelopmental Toxicity in Neurospheres - and Novel Computational Approaches for High Content Image Analyses (HCA) (also view Video) | Fritsche, Ellen, M.D. from IUF - Leibniz Research Institute of Environmental Medicine, Germany | 2014/09/25 |
Functional Substitution: Advancing Safer Alternatives Through Use-Based Thinking (also view Video) | Tickner, Joel, PhD, University of Massachusetts Lowell Department of Community Health and Sustainability | 2014/07/31 |
In Vitro Screening For Inter-Individual and Population Vulnerability in Pesticide Mixtures | Abdo, Nour, DVM, MPH, Ph.D. Candidate, Department of Environmental Sciences and Engineering, UNC Chapel Hill | 2014/06/26 |
Developmental Toxicity of Phase I and II ToxCast™ Chemicals to Worms and Fish | Boyd, Windy, PhD, National Institute of Environmental Health Sciences (NIEHS) | 2014/05/22 |
Strynar, Mark, PhD, EPA, ORD, National Exposure Research Laboratory (NERL) and Shuang Liang, EPA, ORD, NERL, Research Triangle Park, NC | 2014/04/24 | |
RASL-Seq: A Gene Expression Platform to Identify Toxicity Mechanisms and Adaptive Responses (also view Video) | Gerhold, David, PhD, National Institutes of Health (NIH), NCATS | 2014/03/20 |
ToxCast: Chemical List(s), Chemical Space, and Chemotype Information (also view Video) | Richard, Ann, PhD, US EPA/ORD/NCCT, Research Triangle Park, NC | 2014/02/27 |
Exploring consumer exposure pathways and patterns of use for chemicals in the environment through the Chemical/Product Categories Database (CPCat) (also view Video . | Dionisio, Kathie, Sc.D., US EPA, ORD NERL, Research Triangle Park, NC | 2014/01/23 |
Mathematically Simplifying PBPK Mixture Systems | LeFew, William, PhD, US EPA, ORD, National Health and Environmental Effects Research Laboratory (NHEERL)/ISTD, Research Triangle Park, NC | 2013/11/21 |
Incorporating Population Variability and Sensitive Subpopulations into Dosimetry for High-Throughput Toxicity Testing | Wetmore, Barbara , PhD, from the Hamner Institute | 2013/10/21 |
Adverse Outcome Pathway Wiki | Edwards, Stephen, US EPA, Research Triangle Park, NC | 2013/09/26 |
A Computational Tool for Defining Conservation of Molecular Initiating Events Across Species | LaLone, Carlie, PhD, US EPA, Duluth, MN | 2013/08/22 |
Cheminformatics and Toxicogenomics for Toxicology Prediction and Mechanistic Insight (also view Video or listen to Audio - For audio, at the prompt, enter your name and email address, choose your player and click to listen) | Daston, George, Research Fellow at Proctor & Gamble | 2013/07/25 |
High Throughput Heuristics Can Forecast Human Exposure to Environmental Chemicals | Wambaugh, John, PhD, US EPA, ORD, NCCT, Research Triangle Park, NC | 2013/06/27 |
Profiling 976 ToxCast Chemicals Across 331 Enzymatic and Receptor Signaling Assays | Sipes, Nisha, PhD, US EPA, ORD, NCCT, Research Triangle Park, NC | 2013/05/23 |
T3DB - The Toxin, Toxin-Target Database | Wishart, David, PhD, University of Alberta,Edmonton, AB, Canada | 2013/04/25 |
CSS Dashboard | Martin, Matthew, PhD, US EPA, ORD, NCCT, Research Triangle Park, NC | 2013/03/28 |
High-Resolution Metabolomics for Environmental Chemical Surveillance and Bioeffect Monitoring | Jones, Dean, PhD, Department of Medicine, Emory University | 2013/02/28 |
Application of Computational Toxicology to Prospective and Diagnostic Ecological Risk Assessment | Villeneuve, Dan, PhD, Research Toxicologist, US EPA Mid-Continent Ecology Division | 2013/01/24 |
Translating Airway Gene Expression into Biomarkers for Tobacco Smoke Exposure and Lung Cancer Detection | Spira, Avrum, M.D., M.Sc., Boston University Medical Center | 2012/12/13 |
Toxicity Screening using Zebrafish Embryos: Form and Function | Padilla, Stephanie, PhD, US EPA, ORD, NHEERL | 2012/09/27 |
Quantitative High Throughput Models for Exposure-Based Chemical Prioritization | Wambaugh, John, PhD, US EPA, ORD, NCCT,Research Triangle Park, NC | 2012/08/23 |
A freely-available, graphical user interface for ToxPi (Toxicological Prioritization Index) | Rusyn, Ivan, MD, PhD, University of North Carolina and David Reif, PhD, US EPA, ORD, NCCT | 2012/07/26 |
State of the Art High-Throughput Approaches to Genotoxicity: Flow Micronucleus, Ames II, GreenScreen and Comet | Aardema, Marilyn J., PhD, Chief Scientific Advisor, Toxicology, Leon Stankowski, PhD, Principal Scientist/Program Consultant, and Kamala Pant, Principal Scientist, BioReliance | 2012/06/28 |
Development and Application of In Vitro Models for Screening Drugs and Environmental Chemicals that Predict Toxicity in Animals and Humans | McKim, James , PhD, DABT, Founder and Chief Science Officer, CeeTox | 2012/05/25 |
Discovering Environmental Causes of Disease: From Exposure Biology to the Exposome | Rappaport, Stephen M., PhD, University of California, Berkeley | 2012/04/26 |
The Texas-Indiana Virtual STAR Center: Zebrafish Models for Developmental Toxicity Screening | Bolin, Maria Bondesson, PhD, University of Houston, Center for Nuclear Receptors and Cell Signaling | 2012/03/22 |
Predictive Hepatic Model Systems from Life Technologies: Strateties in Toxicology & Screening | Ferguson, Stephen, Life Technologies | 2012/01/26 |
Targeted Testing in Tox21 | DeVito, Michael, PhD, National Institute of Environmental Health Sciences | 2011/12/25 |
Vala Sciences Inc: Providing Innovative Strategies for High Content Imaging and Analysis | McDonough, Patrick M., PhD/VP of Biological Sciences, Vala Sciences Inc, | 2011/11/17 |
An Interactive Web Application for ToxPi | Reif, David M., PhD, US EPA, ORD, NCCT | 2012/10/27 |
ExpoCastDB: A Publicly Accessible Database for Observational Exposure Data | Sumit Gangwal, PhD, US EPA, ORD, NCCT | 2011/09/22 |
Computational Toxicology and Prenatal Development | Knudsen, Thomas B., PhD, EPA, ORD, NCCT | 2011/08/25 |
Computational Toxicology and High-Throughput Risk Assessment | Judson, Richard, US EPA, ORD, NCCT | 2011/07/28 |
Advancing the Next Generation of Risk Assessment | Cote, Ila, US EPA, ORD, NCCT | 2011/06/23 |
Predictive Model of Reproductive Toxicity Using ToxCast High Throughput Screening | Martin, Matt, US EPA, ORD | 2011/05/26 |
EPA's Computational Toxicology Communities of Practice Series: Using Life Cycle Assessment for Risk Management | Curran, Mary Ann, US EPA, ORD | 2011/04/28 |
NTP Workshop: Role of Environmental Chemicals in the Development of Diabetes and Obesity | Thayer, Kris, NIEHS/NTP | 2011/03/24 |
Chemical Safety for Sustainability: EPA Research to Meet 21st-Century Needs | Morris, Jeff, US EPA | 2011/02/24 |
Experiencing REACH Exposure Assessments | Lander, Debbie, E.I, DuPont de Nemours and Company | 2011/01/27 |
Overview of ToxCast Phase II Chemicals | Richard, Ann, US EPA | 2010/12/16 |
Toxicant Analysis via High-content Screening of Cellular Circuits | Westwick, John, Odyssey Thera | 2010/11/18 |
Chemical Screening Visualization Tool: Resource for Rapid Chemical Assessment | Chen, Mario, Dupont | 2010/10/28 |
Comprehensive Exposure Narrative | McKoneTom, University of California Los Angeles School of Public Health | 2010/09/21 |
Computational Toxicology Communities of Practice: Older Presentations