The Food and Drug Administration recently announced that methylsynephrine (also known as oxilofrine) “does not meet the statutory definition of a dietary supplement ingredient.” So what does this mean? Products containing methylsynephrine are adulterated and can’t be marketed legally as dietary supplements. Methylsynephrine is also prohibited in sport because it’s a pharmaceutical drug (not currently approved in the U.S) and a stimulant that increases blood pressure and affects heart rate. What’s more, some supplements have been found to contain methylsynephrine in amounts equal to or greater than pharmaceutical doses. 

The consequences of taking methylsynephrine in large amounts or in combination with other stimulants aren’t entirely known, but one product containing this ingredient and other stimulants has been linked to nausea, vomiting, agitation, increased heart rate, chest pain, and cardiac arrest. If you’re considering taking a dietary supplement with methylsynephrine or oxilofrine on the label, you might want to think twice. For more from FDA, please see “Methylsynephrine in Dietary Supplements.” 

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