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Potential Metabolic Activation of a Representative C2-Alkylated Polycyclic Aromatic Hydrocarbon 6-Ethylchrysene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells

Meng Huang, Clementina Mesaros, Suhong Zhang, Ian A. Blair, and Trevor M. Penning*

    Articles ASAP (As Soon As Publishable)

    ASAP articles are edited and published online ahead of issue. See all ASAP articles.

    Aryl Hydrocarbon Receptor Activation Contributes to Benzanthrone-Induced Hyperpigmentation via Modulation of Melanogenic Signaling Pathways

    Sabiya Abbas, Shamshad Alam, Krishna P. Singh, Mahadeo Kumar, Shailendra K. Gupta, and Kausar M. Ansari
    Publication Date (Web): December 28, 2016 (Article)
    DOI: 10.1021/acs.chemrestox.6b00364
    Figure

    Carbamate Insecticides Target Human Melatonin Receptors

    Marina Popovska-Gorevski, Margarita L. Dubocovich, and Rajendram V. Rajnarayanan
    Publication Date (Web): December 27, 2016 (Article)
    DOI: 10.1021/acs.chemrestox.6b00301
    Figure

    Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Linking and Kinase Inhibition

    Jeannie M. CamarilloJody C. Ullery, Kristie L. Rose, Lawrence J. Marnett
    Publication Date (Web): December 15, 2016 (Article)
    DOI: 10.1021/acs.chemrestox.6b00374
    Figure

    DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine

    Alessia StornettaMaike Zimmermann, George D. Cimino, Paul T. Henderson, Shana J. Sturla
    Publication Date (Web): December 12, 2016 (Perspective)
    DOI: 10.1021/acs.chemrestox.6b00380
    Figure

    Cytotoxicity of Tirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide)-Induced DNA Damage in Chicken DT40 Cells

    Takahito Moriwaki, Saki Okamoto, Hiroyuki SasanumaHideko Nagasawa, Shunichi Takeda, Shin-ichiro Masunaga, Keizo Tano
    Publication Date (Web): December 12, 2016 (Article)
    DOI: 10.1021/acs.chemrestox.6b00417
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    Just Accepted Manuscripts

    Just Accepted manuscripts are peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing. See all Just Accepted Manuscripts.

    Crowd-sourced verification of computational methods and data in systems toxicology: a case study with a heat-not-burn candidate modified risk tobacco product

    Carine Poussin, Vincenzo Belcastro, Florian Martin, Stéphanie Boué, Manuel C Peitsch, and Julia Hoeng
    Publication Date (Web): January 13, 2017 (Article)
    DOI: 10.1021/acs.chemrestox.6b00345
    Figure

    APPLICATION OF 2-AMINOTHIAZOLINE-4-CARBOXYLIC ACID AS A FORENSIC MARKER OF CYANIDE EXPOSURE

    Monika Rużycka, Joanna Giebułtowicz, Marcin Fudalej, Paweł Krajewski, and Piotr Wroczyński
    Publication Date (Web): January 12, 2017 (Article)
    DOI: 10.1021/acs.chemrestox.6b00219
    Figure

    Modulation of cytotoxicity by transcription-coupled nucleotide excision repair is independent of the requirement for bioactivation of acylfulvene

    Claudia Otto, Graciela Spivak, Claudia Marie Nathalie Aloisi, Mirco Menigatti, Hanspeter Nägeli, Philip C. Hanawalt, Marina Tanasova, and Shana J Sturla
    Publication Date (Web): January 11, 2017 (Article)
    DOI: 10.1021/acs.chemrestox.6b00240
    Figure

    Virtual cross-linking of the active nemorubicin metabolite PNU-159682 to double-stranded DNA

    Matteo Scalabrin, Luigi Quintieri, Manlio Palumbo, Federico Riccardi Sirtori, and Barbara Gatto
    Publication Date (Web): January 9, 2017 (Article)
    DOI: 10.1021/acs.chemrestox.6b00362
    Figure

    Honokiol inhibits DNA polymerases β and λ and increases bleomycin sensitivity of human cancer cells

    Prakasha Gowda, Zucai Suo, and Thomas E Spratt
    Publication Date (Web): January 9, 2017 (Article)
    DOI: 10.1021/acs.chemrestox.6b00451
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    Current Issue

    The latest published issue of Chemical Research in Toxicology. See all articles.

    Introduction: Mass Spectrometry and Emerging Technologies for Biomarker Discovery in the Assessment of Human Health and Disease

    Emre M. Isin and Robert J. Turesky
    Publication Date (Web): December 19, 2016 (Editorial)
    DOI: 10.1021/acs.chemrestox.6b00429
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    Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology

    Hiroshi Yamazaki, Hiroshi Suemizu, Marina Mitsui, Makiko Shimizu, and F. Peter Guengerich
    Publication Date (Web): June 23, 2016 (Review)
    DOI: 10.1021/acs.chemrestox.6b00136
    Figure

    Mass Spectrometric and Functional Aspects of Drug–Protein Conjugation

    Arun Tailor, James C. Waddington, Xiaoli Meng, and B. Kevin Park
    Publication Date (Web): September 30, 2016 (Review)
    DOI: 10.1021/acs.chemrestox.6b00147
    Figure

    Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

    Volker M. Lauschke, Delilah F. G. Hendriks, Catherine C. Bell, Tommy B. Andersson, and Magnus Ingelman-Sundberg
    Publication Date (Web): September 23, 2016 (Review)
    DOI: 10.1021/acs.chemrestox.6b00150
    Figure

    Computational Metabolomics: A Framework for the Million Metabolome

    Karan Uppal, Douglas I. Walker, Ken Liu, Shuzhao Li, Young-Mi Go, and Dean P. Jones
    Publication Date (Web): September 14, 2016 (Review)
    DOI: 10.1021/acs.chemrestox.6b00179
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    Most Read articles are refreshed daily and are based on full text downloads (PDF and HTML) from the previous 30 days and previous 12 months. Below is a Top 5 excerpt from the previous 30 days.

    Biomonitoring Human Albumin Adducts: The Past, the Present, and the Future

    Gabriele Sabbioni and Robert J. Turesky
    Publication Date (Web): December 18, 2016 (Perspective)
    DOI: 10.1021/acs.chemrestox.6b00366
    Figure

    Prospects for Applying Synthetic Biology to Toxicology: Future Opportunities and Current Limitations for the Repurposing of Cytochrome P450 Systems

    James B. Y. H. Behrendorff and Elizabeth M. J. Gillam
    Publication Date (Web): November 29, 2016 (Perspective)
    DOI: 10.1021/acs.chemrestox.6b00396
    Figure

    Development and Validation of a Computational Model for Androgen Receptor Activity

    Nicole C. Kleinstreuer, Patricia Ceger, Eric D. Watt, Matthew Martin, Keith Houck, Patience Browne, Russell S. Thomas, Warren M. Casey, David J. Dix, David Allen, Srilatha Sakamuru, Menghang Xia, Ruili Huang, and Richard Judson
    Publication Date (Web): November 18, 2016 (Article)
    DOI: 10.1021/acs.chemrestox.6b00347
    Figure

    A Comparison of Mainstream and Sidestream Marijuana and Tobacco Cigarette Smoke Produced under Two Machine Smoking Conditions

    David Moir, William S. Rickert, Genevieve Levasseur, Yolande Larose, Rebecca Maertens, Paul White and Suzanne Desjardins
    Publication Date (Web): December 7, 2007 (Article)
    DOI: 10.1021/tx700275p
    Figure

    Chemical Composition of Aerosol from an E-Cigarette: A Quantitative Comparison with Cigarette Smoke

    Jennifer Margham, Kevin McAdam, Mark Forster, Chuan Liu, Christopher Wright, Derek Mariner, and Christopher Proctor
    Publication Date (Web): September 18, 2016 (Article)
    DOI: 10.1021/acs.chemrestox.6b00188
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    View the most recent ACS Editors' Choice articles from Chemical Research in Toxicology.

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