Methyl isobutyl ketone (MIBK)

CASRN 108-10-1

Toxicological Review (PDF) (68 pp, 547 K)
IRIS Summary (PDF) (23 pp, 162 K)
Status: Methyl isobutyl ketone (MIBK) is not being reassessed by IRIS at this time.

Reference Dose for Oral Exposure (RfD) (PDF) (23 pp, 162 K) last updated: 04/25/2003
Information reviewed but value not estimated.

RfC (mg/m³)	System	Basis	PoD	Composite UF	Confidence
3	Developmental, Musculoskeletal	Reduced fetal body weight, skeletal variations, and increased fetal death in mice, and skeletal variations in rats.	NOAEL (HEC): 1026 mg/m³	300	Low/Medium

Weight of Evidence for Cancer (PDF) (23 pp, 162 K) last updated: 04/25/2003

WOE Characterization	Framework for WOE Characterization
Data are inadequate for an assessment of human carcinogenic potential	Revised Draft Guidelines for Carcinogen Risk Assessment (US EPA, 1999)

Basis:

Under the draft revised cancer guidelines (U.S. EPA, 1999), the data for MIBK are inadequate for an assessment of human carcinogenic potential. No data were located regarding the existence of an association between cancer and MIBK exposure in humans, but studies of the in vivo and in vitro genotoxicity of MIBK overwhelmingly provided negative responses.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

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