Tetrahydrofuran

CASRN 109-99-9

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (26 pp, 242 K) last updated: 02/21/2012

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
9 x10-1 Developmental Decreased pup body weight gain BMDL1SD : 928
mg/kg-day 		1000 Low/Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (26 pp, 242 K) last updated: 02/21/2012

RfC (mg/m3) System Basis PoD Composite UF Confidence
2 Nervous, Hepatic Increased liver weight and centrilobular cytomegaly, CNS effects (narcosis) BMCL10 : 246 x10-12
mg/m3 		100 Medium/High

Cancer Assessment


Weight of Evidence for Cancer (PDF) (26 pp, 242 K) last updated: 02/21/2012

WOE Characterization Framework for WOE Characterization
Suggestive evidence of carcinogenic potential Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under EPA’s Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for THF provides "suggestive evidence of carcinogenic potential."
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (26 pp, 242 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (26 pp, 242 K)

Not assessed under the IRIS Program.

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Critical Effect Systems

Developmental
Developmental
Hepatic
Hepatic
 
Nervous
Nervous

Chemical Structure for
Tetrahydrofuran

Tetrahydrofuran

Synonyms

  • 1,4-epoxy butane
  • 109-99-9
  • THF
  • Tetrahydrofuran
  • diethyleneoxide

    • more synonyms