EPA Science Advisory Board (SAB)

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IRIS Assessment for Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

EPA Designated Federal Officer (DFO):Diana Wong
202-564-2049
wong.diana-m@epa.gov
Responsible Committee/Panel:Chemical Assessment Advisory Committee (CAAC) Augmented for the RDX Review

See EPA’s PDF page to learn more about PDF files.


BACKGROUND
The National Center for Environmental Assessment (NCEA) in the EPA’s Office of Research and Development (ORD) develops toxicological reviews/assessments for various chemicals for IRIS. NCEA is developing a draft IRIS assessment for Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and has asked the SAB to peer review the draft document. The draft will be a reassessment of RDX. NCEA’s draft Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) currently posted to the IRIS database includes an oral reference dose (RfD) (posted in 1988), and a cancer descriptor and oral cancer slope factor (posted in 1990). Epidemiological data, experimental animal data, and other relevant data from studies of the noncancer and cancer effects of RDX are being evaluated in this reassessment. The reassessment is expected to include an updated RfD and oral cancer assessment.

Agency Charge . (PDF, 7 pp., 300,445 bytes)

Agency Review Document(s):

PDF for IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) - External Review Draft (September, 2016). (PDF, 163 pp., 2,297,443 bytes)

PDF for IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), Supplemental Information - External Review Draft (September 2016). (PDF, 161 pp., 2,328,820 bytes)