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- Therapeutics, Targets, and Chemical Biology | AuthorChoiceMaud-Emmanuelle Gilles, Federica Maione, Mélissande Cossutta, Gilles Carpentier, Laure Caruana, Silvia Di Maria, Claire Houppe, Damien Destouches, Ksenya Shchors, Christopher Prochasson, Fabien Mongelard, Simona Lamba, Alberto Bardelli, Philippe Bouvet, Anne Couvelard, José Courty, Enrico Giraudo and Ilaria CasconeCancer Res December 15 2016 76 (24) 7181-7193; DOI:10.1158/0008-5472.CAN-16-0300
These findings highlight an actionable target in pancreatic cancer that coordinates tumor progression and angiogenesis, in which inhibition might be therapeutically exploited to improve drug delivery and efficacy.
- Tumor and Stem Cell BiologyPeng Cheng, Jia Wang, Indrayani Waghmare, Stefania Sartini, Vito Coviello, Zhuo Zhang, Sung-Hak Kim, Ahmed Mohyeldin, Marat S. Pavlyukov, Mutsuko Minata, Claudia L.L. Valentim, Rishi Raj Chhipa, Krishna P.L. Bhat, Biplab Dasgupta, Concettina La Motta, Madhuri Kango-Singh and Ichiro NakanoCancer Res December 15 2016 76 (24) 7219-7230; DOI:10.1158/0008-5472.CAN-15-2860
These findings define a core pathway controling the clonogenic and tumorigenic potential of an aggressive mesenchymal subtype of stem-like cells in glioblastoma.
- Molecular and Cellular PathobiologySarah Chiang, Britta Weigelt, Huei-Chi Wen, Fresia Pareja, Ashwini Raghavendra, Luciano G. Martelotto, Kathleen A. Burke, Thais Basili, Anqi Li, Felipe C. Geyer, Salvatore Piscuoglio, Charlotte K.Y. Ng, Achim A. Jungbluth, Jörg Balss, Stefan Pusch, Gabrielle M. Baker, Kimberly S. Cole, Andreas von Deimling, Julie M. Batten, Jonathan D. Marotti, Hwei-Choo Soh, Benjamin L. McCalip, Jonathan Serrano, Raymond S. Lim, Kalliopi P. Siziopikou, Song Lu, Xiaolong Liu, Tarek Hammour, Edi Brogi, Matija Snuderl, A. John Iafrate, Jorge S. Reis-Filho and Stuart J. SchnittCancer Res December 15 2016 76 (24) 7118-7129; DOI:10.1158/0008-5472.CAN-16-0298
This study reports molecular biomarkers for a rare form of breast cancer by identifying IDH2 and PIK3CA driver mutations that may help diagnose this disease and possibly direct its more effective treatment.
- ReviewsAnurag K. Singh and Joseph P. McGuirkCancer Res November 15 2016 76 (22) 6445-6451; DOI:10.1158/0008-5472.CAN-16-1311
- ReviewsEileen Shiuan and Jin ChenCancer Res November 15 2016 76 (22) 6452-6457; DOI:10.1158/0008-5472.CAN-16-1521
- ReviewsCaroline H. Johnson, Mary E. Spilker, Laura Goetz, Scott N. Peterson and Gary SiuzdakCancer Res November 1 2016 76 (21) 6146-6152; DOI:10.1158/0008-5472.CAN-16-0309
- ReviewsJ. Jason Morton, Gregory Bird, Yosef Refaeli and Antonio JimenoCancer Res November 1 2016 76 (21) 6153-6158; DOI:10.1158/0008-5472.CAN-16-1260
OnlineFirst Articles
- CypB/STAT3/miR-520d-5p Feedback Loop Regulates GC GrowthTing Li, et al.
- Estrogen Metabolism and Breast Cancer RiskJoshua N. Sampson, et al.
- Sunitinib enhances treatment resistant BC metastasisJoseph W Wragg, et al.
- miR-194 promotes prostate cancer metastasisRajdeep Das, et al.
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