Microscopy
Advancement in energy, environment and biology research relies heavily on micro-, nano- and atomic-scale chemical and structural imaging. Many microscopy instruments have high-resolution imaging capabilities including complementary chemical, structural and phase information, in-situ imaging in native environments and imaging of dynamic processes with high temporal-resolution. See a complete list of Microscopy instruments.
Resources and Techniques
- Nanoscale and sub-nanoscale imaging allows users to elucidate chemical processes and acquire structural data for a variety of samples such as nanostructures and cell-surface proteins.
- Tomography yields three-dimensional reconstruction of transmission electron microscopy images generated for biological samples as well as for soft materials and samples with 3D structural heterogeneity.
- Environmental particle analysis offers knowledge about non-volatile atmospheric particle composition and hydration properties using high-pressure scanning electron microscopy equipped with energy-dispersive x-ray analysis capability.
- Environmental mode imaging techniques enable sample preservation to eliminate extensive preparation procedures that can introduce artifacts and make possible live-cell imaging and in situ imaging in liquids or controlled gas environments with high resolution microscopy.
- Dynamic imaging capability enables real-time studies of nanosecond-scale dynamic processes with unprecedented spatial resolution, such as protein-protein interactions, with contrast at the single-molecule level.
Quiet Wing for Advanced Microscopy
Seven microscopes are housed in the Quiet Wing, a space specially designed to reduce external factors, such as vibrations and electromagnetic fields, that can impede capture of high-resolution images. Read more about the Quiet Wing and its instrumentation.
A new DTEM – Dynamic Transmission Electron Microscope – is under development at EMSL in collaboration with scientific colleagues at Pacific Northwest National Laboratory. It will be housed in the Quiet Wing. To learn more about this system, the science it will advance and its historical development, visit the DTEM page.
Advancement in energy, environment and biology research relies heavily on micro-, nano- and atomic-scale chemical and structural imaging. Many microscopy instruments have high-resolution imaging capabilities including complementary chemical, structural and phase information, in-situ imaging in native environments and imaging of dynamic processes with high temporal-resolution. See a complete list of Microscopy instruments.
Resources and Techniques
- Nanoscale and sub-nanoscale imaging allows users to elucidate chemical processes and acquire structural data for a variety of samples such as nanostructures and cell-surface proteins.
- Tomography yields three-dimensional reconstruction of transmission electron microscopy images generated for biological samples as well as for soft materials and samples with 3D structural heterogeneity.
- Environmental particle analysis offers knowledge about non-volatile atmospheric particle composition and hydration properties using high-pressure scanning electron microscopy equipped with energy-dispersive x-ray analysis capability.
- Environmental mode imaging techniques enable sample preservation to eliminate extensive preparation procedures that can introduce artifacts and make possible live-cell imaging and in situ imaging in liquids or controlled gas environments with high resolution microscopy.
- Dynamic imaging capability enables real-time studies of nanosecond-scale dynamic processes with unprecedented spatial resolution, such as protein-protein interactions, with contrast at the single-molecule level.
Quiet Wing for Advanced Microscopy
Seven microscopes are housed in the Quiet Wing, a space specially designed to reduce external factors, such as vibrations and electromagnetic fields, that can impede capture of high-resolution images. Read more about the Quiet Wing and its instrumentation.
A new DTEM – Dynamic Transmission Electron Microscope – is under development at EMSL in collaboration with scientific colleagues at Pacific Northwest National Laboratory. It will be housed in the Quiet Wing. To learn more about this system, the science it will advance and its historical development, visit the DTEM page.
Analytical: Chromatograph, Agilent
Zeta Potential Analyzer
Dynamic TEM (available approx. Oct. 2017)
Non-Linear Ultrasonic Testing and Microstructural-based Modeling towards the Development of Prognostic Damage Maps for Reactor
An In-situ Investigation of a-AlOOH Dissolution under High pH Conditions
Fundamental Understanding of Nucleation Processes to Assess Solution Stability and Phase Growth and Genesis
Morphology and Protein Profile of Bacterium-Membrane-Formed Nanovesicles
Investigating interactions and aggregate structures of boehmite particles toward understanding of bulk rheology
Optimize your research with EMSL capabilities
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Description
Capability Details
• Electron microscopes with tomography, cryo, scanning, photoemission and high-resolution (sub-nanometer) imaging capabilities
• Focused ion beam/scanning electron microscopes for specialized sample preparation and three-dimensional topographic and chemical imaging
• Nuclear magnetic resonance microscopy with 10-40-_m resolution to study the anatomy, metabolism and transport processes of live cell cultures, biofilms and tissue samples
• Dual Raman confocal microscope for analysis of radiological samples
• Single-molecule fluorescence tools to study molecular interactions in real time
• Scanning probe microscopy with capabilities ranging from examination of dynamic nanoscale processes in condensed environments to high resolution studies of catalysis materials in ultra-high vacuum.
Instruments
Publications
Science Highlights
Instruments
Leads
Dr. Lea provides scientific and technical expertise and leadership in support of EMSL’s user program, strategy and scientific productivity through leadership of microscopy capability and Quiet Wing for advanced microscopy. He also oversees...