Chromium(VI)
CASRN 18540-29-9
- Toxicological Review (PDF) (70 pp, 195 K)
- IRIS Summary (PDF) (34 pp, 203 K)
- Status: Chromium(VI) is in step 1 at this time; see Quick Check.
Health Hazard Assessments for Effects Other than Cancer
Reference Dose for Oral Exposure (RfD) (PDF) (34 pp, 203 K)
last updated: 09/03/1998
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Reference Concentration for Inhalation Exposure (RfC) (PDF) (34 pp, 203 K)
last updated: 09/03/1998
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Cancer Assessment
Weight of Evidence for Cancer (PDF) (34 pp, 203 K)
last updated: 09/03/1998
WOE Characterization | Framework for WOE Characterization |
---|---|
A (Human carcinogen) (Inhalation route) | Guidelines for Carcinogen Risk Assessment (US EPA, 1986) |
D (Not classifiable as to human carcinogenicity) (Oral route) | Guidelines for Carcinogen Risk Assessment (US EPA, 1986) |
Carcinogenic potential cannot be determined (Oral route) | Proposed Guidelines for Carcinogen Risk Assessment (US EPA, 1996) |
Known/likely human carcinogen (Inhalation route) | Proposed Guidelines for Carcinogen Risk Assessment (US EPA, 1996) |
- Under the current guidelines (EPA, 1986), Cr(VI) is classified as Group A - known human carcinogen by the inhalation route of exposure. Carcinogenicity by the oral route of exposure cannot be determined and is classified as Group D. Under the proposed guidelines (EPA, 1996), Cr(VI) would be characterized as a known human carcinogen by the inhalation route of exposure on the following basis. The oral carcinogenicity of Cr(VI) cannot be determined. No data were located in the available literature that suggested that Cr(VI) is carcinogenic by the oral route of exposure.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (34 pp, 203 K)
Information reviewed but value not estimated.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (34 pp, 203 K)
Inhalation Unit Risk:
1.2 x10 -2 per µg/m3
Extrapolation Method:
Multistage, extra risk
Tumor site(s): Respiratory
Tumor type(s): Lung cancer (Mancuso, 1975)
Chromium(VI) is being reassessed.
Assessment Manager(s): Catherine Gibbons (gibbons.catherine@epa.gov), Alan Sasso (sasso.alan@epa.gov)
Step | Assessment Materials Released to the Public | Release Date | Public Meeting Date |
---|---|---|---|
1 | Problem Formulation Materials | 04/2014 | 06/2014 |
1 | Preliminary Assessment Materials | 08/2014 | 10/2014 |
4 | Public Comment Draft | TBD | TBD |
4 | Peer Review Draft | TBD | TBD |
7 | Post Final Assessment | TBD |
Please note: Any future dates displayed under Release Date are estimates and subject to change.
Sep 2013: Hexavalent Chromium Workshop (Other)
Jul 2011: IRIS Toxicological Review Of Hexavalent Chromium (2010 External Review Draft) (Report)
Dec 2010: IRIS Toxicological Review Of Hexavalent Chromium (Peer Review Plan) (Report)
Oct 2008: IRIS Toxicological Review Of Hexavalent Chromium (Interagency Science Consultation Draft) (Report)
Apr 1990: Noncarcinogenic Effects Of Chromium: Update To Health Assessment Document (Report)
Aug 1984: Health Assessment Document For Chromium. Final Report (Report)
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