Phenol

CASRN 108-95-2

RfD (mg/kg-day)	System	Basis	PoD	Composite UF	Confidence
3 x10^-1	Other	Decreased maternal weight gain	BMDL : 93 mg/kg-day	300	Medium/High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (31 pp, 194 K) last updated: 09/30/2002
Information reviewed but value not estimated.

Weight of Evidence for Cancer (PDF) (31 pp, 194 K) last updated: 09/30/2002

WOE Characterization	Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity)	Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Data are inadequate for an assessment of human carcinogenic potential	Revised Draft Guidelines for Carcinogen Risk Assessment (US EPA, 1999)

Basis:

Under Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999), the data regarding the carcinogenicity of phenol via the oral, inhalation, and dermal exposure routes are inadequate for an assessment of human carcinogenic potential. Phenol was negative in oral carcinogenicity studies in rats and mice, but questions remain regarding increased leukemia in male rats in the bioassay as well as the positive gene mutation data and the positive results in dermal initiation/promotion studies at doses at or above the maximum tolerated dose (MTD). No inhalation studies of an appropriate duration exist. Therefore, no quantitative assessment of carcinogenic potential via any route is possible.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

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