US EPA

X-ray CT-based Assessment of Variations in Human Airway Geometry: Implications for Evaluation of Particle Deposition and Dose to Different Populations

EPA Grant Number: R827351C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R827351
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: EPA NYU PM Center: Health Risks of PM Components
Center Director: N/A
Title: X-ray CT-based Assessment of Variations in Human Airway Geometry: Implications for Evaluation of Particle Deposition and Dose to Different Populations
Investigators: Cohen, Beverly S. , Hoffman, Eric
Institution: New York University School of Medicine , University of Iowa
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air

Objective:

Few data are available regarding the regional deposition of particulate matter (PM) in the lungs of people at special risk of environmentally-related lung disease (e.g., those with respiratory diseases, the elderly). The objective of this research project is to investigate the potential for retrieval of morphometric data from three-dimensional images of conducting airways obtained by x-ray computerized tomography (CT), and to explore the potential for the use of stereolithography (STL) to produce hollow airway casts for experimental verification of particle deposition models. This project also will test and validate theoretical and empirical models used to predict detailed particle deposition in living individuals, and ultimately, will allow application of the derived, validated dosimetry models to airways representative of various potentially susceptible subgroups.

Publications and Presentations:

Publications have been submitted on this subproject: View all 1 publications for this subproject | View all 104 publications for this center

Supplemental Keywords:

particulate matter, PM, particulate deposition, exposure, computerized tomagraphy, CT, x-ray, human airway, morphometric data, three-dimensional images, stereolithography, volume, sheep., RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, ENVIRONMENTAL MANAGEMENT, particulate matter, Environmental Chemistry, Health Risk Assessment, Risk Assessments, Environmental Monitoring, Physical Processes, Atmospheric Sciences, Risk Assessment, ambient air quality, particulates, atmospheric particulate matter, air toxics, chemical characteristics, toxicology, atmospheric particles, ambient air monitoring, acute lung injury, environmental risks, exposure, epidemelogy, airborne particulate matter, air pollution, human exposure, atmospheric aerosol particles, aerosol composition, PM, X-ray tomagraphy, airway contractile properties, exposure assessment

Progress and Final Reports:

1999 Progress Report
2000 Progress Report
2001 Progress Report
2002 Progress Report
2003 Progress Report
Final Report

Main Center Abstract and Reports:

R827351    EPA NYU PM Center: Health Risks of PM Components

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827351C001 Exposure Characterization Error
R827351C002 X-ray CT-based Assessment of Variations in Human Airway Geometry: Implications for Evaluation of Particle Deposition and Dose to Different Populations
R827351C003 Asthma Susceptibility to PM_2.5
R827351C004 Health Effects of Ambient Air PM in Controlled Human Exposures
R827351C005 Physicochemical Parameters of Combustion Generated Atmospheres as Determinants of PM Toxicity
R827351C006 Effects of Particle-Associated Irritants on the Cardiovascular System
R827351C007 Role of PM-Associated Transition Metals in Exacerbating Infectious Pneumoniae in Exposed Rats
R827351C008 Immunomodulation by PM: Role of Metal Composition and Pulmonary Phagocyte Iron Status
R827351C009 Health Risks of Particulate Matter Components: Center Service Core
R827351C010 Lung Hypoxia as Potential Mechanisms for PM-Induced Health Effects
R827351C011 Urban PM_2.5 Surface Chemistry and Interactions with Bronchoalveolar Lavage Fluid (BALF)
R827351C012 Subchronic PM2.5 Exposure Study at the NYU PM Center
R827351C013 Long Term Health Effects of Concentrated Ambient PM_2.5
R827351C014 PM Components and NYC Respiratory and Cardiovascular Morbidity
R827351C015 Development of a Real-Time Monitoring System for Acidity and Soluble Components in Airborne Particulate Matter
R827351C016 Automated Real-Time Ambient Fine PM Monitoring System