Andrew Lipton

Andrew S Lipton
Staff Member Title: 
Senior Research Scientist
Contact Email: 
as.lipton@pnnl.gov
Details: 

Technician/NMR operator, Syracuse University, 1987-1988

Postdoctoral Fellow, PNNL, 1993-1996

Senior Research Scientist, PNNL, 1996-2001

Senior Research Scientist II, PNNL, 2001-present

Education: 

Ph.D., Physical Chemistry, University of South Carolina, Columbia, SC, 1993

B.S., Chemistry, Syracuse University, Syracuse, NY, 1987

Awards & Honors: 

Research recognized by Chemical and Engineering News as one of the key biochemistry developments in 2001

PNNL Outstanding Performance Awards, 1999, 2001, 2013

Research Interests: 

Associated with EMSL from its inception as a resource for solid-state NMR users, Dr. Lipton has aided EMSL users in obtaining experimental NMR data of other quadrupolar nuclides in various environments such as bio-inorganic, protein, or mineral samples. Some of the nuclides studied include strontium, calcium, magnesium, deuterium, and copper. Most recently, he has been working on new methods for extracting structural information in the solid-state via NMR methods. These include combining the NMR experiment with molecular theory utilizing NWChem on the EMSL supercomputer, as well as new pulse sequence methods and novel probe development. One of his main research focuses is studying the anti-ferromagnetic manganese cluster in photosystem II (PSII) and model systems using a combination of cryogenic solid-state NMR, EPR, and molecular theory. He is also continuing his interest in Zn2+ binding metalloproteins, particularly in metallo-lactamases that are responsible for antibiotic resistance in microbes. Recently he has begun work on humics, soils and intact plant material utilizing solid-state NMR to follow terrestrial carbon cycling.

Capabilities: 
NMR and EPR
Instrument(s): 
500 MHz NMR Shasta (Solids)
850 MHz NMR Ellis (Solids)

Publications

2015

  • L Dithmer, AS Lipton, K Reitzel, TE Warner, D Lundberg, UG Nielsen. 2015. "Characterization of phosphate sequestration by a lanthanum modified bentonite clay: A solid- state NMR, EXAFS and PXRD study." Environmental Science & Technology 49(7)4559-4566. 10.1021/es506182s
  • L Vugmeyster, D Ostrovsky, T Villafranca, J Sharp, W Xu, AS Lipton, G Hoatson, RL Vold. 2015. "Dynamics of Hydrophobic Core Phenylalanine Residues Probed by Solid-State Deuteron NMR ." Journal of Physical Chemistry B 119(47)14892-14904. 10.1021/acs.jpcb.5b09299
  • SSC Pushparaj, C Forano, V Prevot, AS Lipton, G Rees, JV Hanna, UG Nielsen. 2015. "How the method of synthesis governs the local and global structure of zinc aluminum layered double hydroxides." Journal of Physical Chemistry C 119(49)27695-27707. 10.1021/acs.jpcc.5b09490

2014

  • LB Petersen, AS Lipton, V Zorin, UG Nielsen. 2014. "Local environment and composition of magnesium gallium layered double hydroxides determined from solid-state 1H and 71Ga NMR spectroscopy." Journal of Solid State Chemistry 219242-246. 10.1016/j.jssc.2014.07.023

2013

  • Y Han, G Hou, CL Suiter, J Ahn, IJL Byeon, AS Lipton, SD Burton, I Hung, PL Gorkov, Z Gan, WW Brey, DM Rice, AM Gronenborn, TE Polenova. 2013. "Magic Angle Spinning NMR Reveals Sequence-Dependent Structural Plasticity, Dynamics, and the Spacer Peptide 1 Conformation in HIV-1 Capsid Protein Assemblies." Journal of the American Chemical Society 135(47)17793-17803. 10.1021/ja406907h
  • JH Kwak, JH Lee, SD Burton, AS Lipton, CHF Peden, J Szanyi. 2013. "A common intermediate for N2 formation in enzymes and zeolites: side-on Cu-nitrosyl complexes." Angewandte Chemie International Edition 52(38)9985-9989. 10.1002/anie.201303498
  • JS McCloy, BJ Riley, AS Lipton, CF Windisch, NM Washton, MJ Olszta, CP Rodriguez. 2013. "Structure and Chemistry in Halide Lead-Tellurite Glasses." Journal of Physical Chemistry C 117(7)3456-3466. 10.1021/jp310820t
  • KT Mueller, M Pruski, NM Washton, AS Lipton. 2013. "Science Drivers and Technical Challenges for Advanced Magnetic Resonance."
  • L Vugmeyster, D Ostrovsky, AS Lipton. 2013. "Origin of Abrupt Rise in Deuteron NMR Longitudinal Relaxation Times of Protein Methyl Groups Below 90 K." Journal of Physical Chemistry B 117(20)6129-6137. 10.1021/jp4021596

2011

  • R Koch, AS Lipton, S Filipek, VM Renugopalakrishnan. 2011. "Arginine Interactions with Anatase TiO2 (100) Surface and the Perturbation of 49Ti NMR Chemical Shifts - A DFT Investigation: Relevance to Renu-Seeram Bio Solar Cell." Journal of Molecular Modeling 17(6)1467-1472. 10.1007/s00894-010-0853-y
  • G Comellas Canal, LR Lemkau, AJ Nieuwkoop, KD Kloepper, DT Ladror, R Ebisu, WS Woods, AS Lipton, JM George, CM Rienstra. 2011. "Structured Regions of Alpha-synuclein Fibrils Include the Early Onset Parkinson's Disease Mutation Sites." Journal of Molecular Biology 411(4)881-895. 10.1016/j.jmb.2011.06.026

2010

  • LJ Sperling, AJ Nieuwkoop, AS Lipton, DA Berthold, CM Rienstra. 2010. "High Resolution NMR Spectroscopy of Nanocrystalline Proteins at Ultra-High Magnetic Field." Journal of Biomolecular NMR 46(2)149-155. 10.1007/s10858-009-9389-9
  • L Vugmeyster, D Ostrovsky, JJ Ford, AS Lipton. 2010. "Freezing of Dynamics of a Methyl Group in a Protein Hydrophobic Core at Cryogenic Temperatures by Deuteron NMR Spectroscopy." Journal of the American Chemical Society 132(12)4038-4039. 10.1021/ja909599k
  • PD Ellis, JA Sears, P Yang, M Dupuis, T Boron, V Pecoraro, T Stich, RDavid Britt, AS Lipton. 2010. "Solid-State 55Mn NMR Spectroscopy of bis(μ-oxo)dimanganese(IV) [Mn2O2(salpn)2], a Model for the Oxygen Evolving Complex in Photosystem II." Journal of the American Chemical Society 132(47)16727-16729. 10.1021/ja1054252
  • L Vugmeyster, D Ostrovsky, M Moses, JJ Ford, AS Lipton, G Hoatson, RL Vold. 2010. "Comparative Dynamics of Leucine Methyl Groups in FMOC-Leucine and in a Protein Hydrophobic Core Probed by Solid-State Deuteron Nuclear Magnetic Resonance over 7-324 K Temperature Range." Journal of Physical Chemistry B 114(48)15799-15807.
  • MC Davis, WJ Brouwer, AS Lipton, Z Gan, KT Mueller. 2010. "Characterization of cation environments in polycrystalline forsterite by Mg-25 MAS, MQMAS, and QCPMG NMR ." American Mineralogist 95(11-12)1601-1607. 10.2138/am.2010.3403

2009

  • L Vugmeyster, D Ostrovsky, JJ Ford, SD Burton, AS Lipton, G Hoatson, RL Vold. 2009. "Probing the Dynamics of a Protein Hydrophobic Core by Deutron Solid-State Nuclear Magnetic Resonance Spectroscopy ." Journal of the American Chemical Society 131(38)13651-13658. 10.1021/ja902977u
  • AS Lipton, RW Heck, WA De Jong, AR Gao, X Wu, A Roehrich, GS Harbison, PD Ellis. 2009. "Low Temperature 65 Cu NMR Spectroscopy of the Cu+ Site in Azurin." Journal of the American Chemical Society 131(39)13992-13999. 10.1021/ja901308v
  • AS Lipton, PD Ellis, TE Polenova. 2009. "Quadrupolar Metal Nuclides in Bioinorganic Chemistry: Solid-State NMR Studies."
  • MC Davis, WJ Brouwer, DJ Wesolowski, LM Anovitz, AS Lipton, KT Mueller. 2009. "Magnesium Silicate Dissolution Investigated by 29Si MAS, 1H-29Si CP MAS, 25Mg QCPMG, and 1H-25Mg CP QCPMG NMR." Physical Chemistry Chemical Physics. PCCP 11(32)7013-7021. 10.1039/b907494e

2008

  • HM Cho, WJ Shaw, VM Parvanov, GK Schenter, AJ Karkamkar, NJ Hess, CJ Mundy, SM Kathmann, JA Sears, AS Lipton, PD Ellis, T Autrey. 2008. "Molecular Structure and Dynamics in the Low Temperature (Orthorhombic) Phase of NH3BH3." Journal of Physical Chemistry A 112(18)4277-4283.
  • AS Lipton, RW Heck, SV Primak, DR McNeill, DM Wilson Iii, PD Ellis. 2008. "Characterization of Mg²⁺ Binding to the DNA Repair Protein Apurinic/Apyrimidic Endonuclease 1 via Solid-State ²⁵Mg NMR Spectroscopy." Journal of the American Chemical Society 130(29)9332-9341. 10.1021/ja0776881
  • LS Bouchard, AO Sushkov, D Budker, J Ford, AS Lipton. 2008. "Nuclear-spin relaxation of ²º⁷Pb in ferroelectric powders." Physical Review. A. 77(2)Art. No. 022102. 10.1103/PhysRevA.77.022102
  • AS Lipton, MM Morlok, G Parkin, PD Ellis. 2008. "67Zn Solid-State NMR Spectroscopy of {[TpBut,Me]Zn(OH2)}[HOB(C6F5)3]. The Importance of the Anion [HOB(C6F5)3]-." Inorganic Chemistry 47(12)5184-5189. 10.1021/ic800009b
  • AS Lipton, RW Heck, GR Staeheli, M Valiev, WA De Jong, PD Ellis. 2008. "A QM/MM Approach to Interpreting Zn-67 Solid-State NMR data in Zinc Proteins." Journal of the American Chemical Society 130(19)6224-6230.
  • AS Lipton, RW Heck, M Hernick, CA Fierke, PD Ellis. 2008. "Residue Ionization in LpxC Directly Observed by 67Zn NMR Spectroscopy." Journal of the American Chemical Society 130(38)12671-12679. 10.1021/ja801776c
  • GA Bowmaker, JV Hanna, FE Hahn, AS Lipton, CE Oldham, BW Skelton, ME Smith, AH White. 2008. "Structural and spectroscopic studies of some copper(I) halide tert-butyl isocyanide adducts." Journal of the Chemical Society. Dalton Transactions 2008(13)1710-1720. 10.1039/b712815k

2007

  • PD Ellis, AS Lipton. 2007. "Low Temperature Solid-State NMR Spectroscopy. A Strategy for the Direct Observation of Quadrupolar Nuclides of Biological Interest.."
  • AS Lipton, PD Ellis. 2007. "Modeling the Metal Center of Cys4 Zinc Proteins." Journal of the American Chemical Society 129(29)9192-9200. 10.1021/ja071430t

2006

  • FH Larsen, IE Farnan, AS Lipton. 2006. "Separation of 47Ti and 49Ti Solid-State NMR Lineshapes by Static QCPMG Experiments at Multiple Fields." Journal of Magnetic Resonance 178(2)228-236.
  • GM Bowers, AS Lipton, KT Mueller. 2006. "High-field QCPMG NMR of Strontium Nuclei in Natural Minerals." Solid State Nuclear Magnetic Resonance 29(1-3)95-103.

2004

  • AS Lipton, RW Heck, PD Ellis. 2004. "Zinc Solid-State NMR Spectroscopy of Human Carbonic Anhydrase: Implications for the Enzymatic Mechanism.." Journal of the American Chemical Society 126(14)4735-4739.
  • AS Lipton, RW Heck, JA Sears, PD Ellis. 2004. "Low Temperature Solid-State NMR Experiments of Half-Integer Quadrupolar Nuclides: Caveats and Data Analysis." Journal of Magnetic Resonance 16866-74.

2003

  • AS Lipton, C Bergquist, G Parkin, PD Ellis. 2003. "Solid-state Zn-67 NMR Spectroscopic Studies and ab initio Molecular Orbital Calculations on a Synthetic Analogue of Carbonic Anhydrase. ." Journal of the American Chemical Society 125(13)3768-3772.

2002

  • AS Lipton, MD Smith, RD Adams, PD Ellis. 2002. "Zn-67 Solid-State and Single-Crystal NMR Spectroscopy and X-ray Crystal Structure of Zinc Formate Dihydrate." Journal of the American Chemical Society 124(3)410-414.
  • AS Lipton, T Wright, MK Bowman, DL Reger, PD Ellis. 2002. "Solid State 67Zn NMR Spectroscopy in Bioinorganic Chemistry. Spectra of 4-and 6-Coordinate Zinc Pyrazolylborate Complexes Obtained by Management of Proton Relaxation Rates with a Paramagnetic Dopant.." Journal of the American Chemical Society .124(20)5850-5860.

2001

  • AS Lipton, GW Buchko, JA Sears, MA Kennedy, PD Ellis. 2001. "Zn-67 Solid-State NMR Spectroscopy of the Minimal DNA Binding Domain of Human Nucleotide Excision Repair Protein XPA." Journal of the American Chemical Society 123(5)992-993.
  • GA Bowmaker, JV Hanna, CE Rickard, AS Lipton. 2001. "Crystal Structures and Vibrational and Solid-State (CPMAS) NMR Spectroscopy of Some Bis(triphenylphosphine)silver(I) Sulfate, Selenate and Phosphate Systems.." Journal of the Chemical Society. Dalton Transactions Array(2001)20-28.
  • AS Lipton, JA Sears, PD Ellis. 2001. "A General Strategy for the NMR Observation of Half -Integer Quadrupolar Nuclei in Dilute Environments." Journal of Magnetic Resonance 151(1)48-59.
  • AS Lipton, MD Smith, RD Adams, PD Ellis. 2001. "67Zn Solid-State and Single-Crystal NMR Spectroscopy and X-ray Crystal Structure of Zinc Formate Dihydrate." Journal of the American Chemical Society 124(3)410-414.

1999

  • DM Jacobs, AS Lipton, NG Isern, GW Daughdrill, DF Lowry, X Gomes, MS Wold. 1999. "Human Replication Protein A: Global Fold of the N-terminal RPA-70 Domain Reveals a Basic Cleft and Flexible C-terminal Linker." Journal of Biomolecular NMR 14(1999)321-331.
  • FH Larsen, AS Lipton, HJ Jakobsen, NC Nielsen, PD Ellis. 1999. "67Zn QCPMG Solid-State NMR Studies of Zinc Complexes as Models for Metalloproteins." Journal of the American Chemical Society 121(15)3783-3784.