Biosystem Dynamics & Design

Biosystem Dynamics and Design focuses on regulation of spatial and temporal parameters of metabolic processes in microbes, fungi, and plants. By gaining a detailed understanding of how biological systems respond to and modify their environment, EMSL can improve strategies for modifying and manipulating plants, fungi and microbes to advance systems biology for bioenergy and biorenewables.

Within this science theme, EMSL will employ our research and that of our users for:

  • Metabolic compartmentalization: Integrate molecular-scale information to determine the design principles underlying biological compartments, structures and networks such as lipid particles and peroxisomes in plants and fungi, and the carboxysome in cyanobacteria.

Biosystem Dynamics and Design focuses on regulation of spatial and temporal parameters of metabolic processes in microbes, fungi, and plants. By gaining a detailed understanding of how biological systems respond to and modify their environment, EMSL can improve strategies for modifying and manipulating plants, fungi and microbes to advance systems biology for bioenergy and biorenewables.

Within this science theme, EMSL will employ our research and that of our users for:

  • Metabolic compartmentalization: Integrate molecular-scale information to determine the design principles underlying biological compartments, structures and networks such as lipid particles and peroxisomes in plants and fungi, and the carboxysome in cyanobacteria.

Pages

Leads

(509) 372-4759

Dr. Baker is the science theme lead for Biosystem Dynamics and Design, which focuses on spatial and temporal dynamics of biological pathways in microbes, fungi and plants to advance our understanding of the carbon cycle and accelerate production...

Instruments

Research Applications Characterization of quadrupolar nuclei for inorganic and biological materials and natural sediments Cryogenic NMR capabilities...
Highlighted Research Applications EMSL's Bruker 500-MHz WB spectrometer is uniquely tailored for in vivo studies: Microbial biofilms relevant to...
Custodian(s):
Type of Instrument:
Nuclear Magnetic Resonance Spectrometer (NMR)
Research Applications Dynamics studies via 2H NMR Characterization of quadrupolar nuclei for materials and biological samples Characterization of...
Two massively parallel next-generation sequencing platforms (SOLiD 5500 series) are currently incorporated in users' research for transcriptomics...
Custodian(s): Galya Orr, Lye Meng Markillie
Highlighted Research Applications Structural biology Protein structure and dynamics Nuclei acid structure and dynamics. Metabolomics Eukaryotic and...
Custodian(s): Nancy Isern, David Hoyt

Publications

Post-translational modifications (PTMs) play an important role in various biological processes through changing protein structure and function. Some...
Prokaryotes, due to their moderate complexity, are particularly amenable to the comprehensive identification of the protein repertoire expressed...
Surface functionalized magnetic nanoparticles (MNPs) are appealing candidates for analytical separation of heavy metal ions from waste water and...
The interactions between proteins and surfaces are critical to a number of important processes including biomineralization, the biocompatibility of...
Phototrophic microbial mats are among the most diverse ecosystems in nature. These systems undergo daily cycles in redox potential caused by...

Science Highlights

Posted: December 05, 2016
The Science A recent study demonstrated enormous potential for scientists to explore extremely complex molecular mixtures and systems frequently...
Posted: November 28, 2016
Tom Rickey, PNNL Genetics and birthplace have a big effect on the make-up of the microbial community in the gut, according to research published Nov...
Posted: October 31, 2016
The Science Marine organisms such as corals and some plankton build calcium carbonate (CaCO3) shells. The elements that make up these shells play a...
Posted: September 22, 2016
The Science Soil metagenomics have been termed a grand challenge due to the complexity and diversity of microbial communities in soil ecosystems. A...
Posted: September 14, 2016
The Science Peptides are naturally occurring molecules with excellent pharmaceutical properties, but their therapeutic use has been limited by the...

Instruments

The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our...
Microbial activities on which humanity and ecosystems depend, and which influence climate and support biofuel production, are determined both by...
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our...
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our...
This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “...