Toxicological Profiles
Information About Contaminants Found at Hazardous Waste Sites
Substance Index for ToxProfiles
* denotes tox profiles funded by the Department of Defense.
A
- Acetone (PB/95/100095/AS)
- Acrolein (Updated) (PB2008-100001)
- Acrylamide (PB2013-107047)
- Acrylonitrile (PB/91/180489/AS)
- Aldrin/Dieldrin (Updated) (PB2003-100134)
- Aluminum (Updated) (PB2009-100001)
- Americium (PB2004-104396)
- Ammonia (Updated) (PBPB2004-107331)
- Antimony (PB/93/110641/AS)
- Arsenic (Updated) (PB2008-100002)
- Asbestos (Updated) (PB/2001/109101)
- Atrazine (PB2004-100001)
B
- 1,3-Butadiene (Updated) (PB2013-105789)
- 1-Bromopropane (Draft for Public Comment)
- 2,3-Benzofuran (PB/93/110666/AS)
- 2-Butanone (PB/93/110708/AS)
- 2-Butoxyethanol and 2-Butoxyethanol Acetate (PB/99/102527/AS)*
- Barium (Updated) (PB2008-100003)
- Benzene (Updated) (PB2008-100004)
- Benzidine (Updated) (PB/2001/109102)
- Beryllium (Draft for Public Comments)
- Bis(2-chloroethyl) Ether (PB/90/168683/AS)
- Bis(chloromethyl) Ether (PB/90/168691/AS)
- Boron (Updated) (PB2010-100001)
- Bromodichloromethane (PB/90/167461/AS)
- Bromoform & Dibromochloromethane (Updated) (PB2006-100001)
- Bromomethane (PB/93/110682/AS)
C
- Cadmium (Updated) (PB2013-105787)
- Carbon Disulfide (PB97-121073)
- Carbon Monoxide (PB2013-105795)
- Carbon Tetrachloride (Updated) (PB2006-100002)
- Cesium (PB2004-104397)
- Chlordane (Updated) (PB/95/100111/AS)
- Chlordecone (PB/95/264354)
- Chlorfenvinphos (PB/98/101116/AS)
- Chlorinated Dibenzo-p-dioxins (CDDs) (Updated) (PB/99/121998)
- Chlorine (PB2010-100002)
- Chlorine Dioxide & Chlorite (PB 2004-107332)
- Chlorobenzene (PB/91/180505/AS)
- Chlorodibenzofurans (CDFs) (PB/95/100129/AS)
- Chloroethane (Updated) (PB/99/121956)
- Chloroform (Updated) (PB/98/101140/AS)
- Chloromethane (Updated) (PB/99/121964)
- Chlorophenols (Updated) (PB/99/166639)
- Chlorpyrifos (PB/98/103088/AS)
- Chromium (PB2013-105788)
- Cobalt (Updated) (PB 2004-10733)
- Copper (Updated) (PB 2004-10733)
- Creosote (Updated) (PB2003-100136)
- Cresols (Updated) (PB2009-100002)
- Cyanide (Updated) (PB2007-100674)
D
- 1,1-Dichloroethane (Final)
- 1,1-Dichloroethene (Updated) (PB/95/100152/AS)
- 1,2-Dibromo-3-Chloropropane (PB/93/110906/AS)
- 1,2-Dibromoethane (PB/93/110740/AS)
- 1,2-Dichloroethane (Updated) (PB/2001/109103/AS)
- 1,2-Dichloroethene (Updated) (PB/97/121081/AS)
- 1,2-Dichloropropane (PB/90/182122/AS)
- 1,2-Diphenylhydrazine (Updated) (PB/91/180356/AS)
- 1,3 Dinitrobenzene & 1,3,5 Trinitrobenzene (PB/95/264289/AS)*
- 1,4-Dioxane (PB2013-105794)
- 3,3'-Dichlorobenzidine (Updated) (PB/99/121980)
- DDT, DDE, DDD (Updated) (PB2003-100137)
- DEET (N,N-diethyl-meta-toluamide) (Draft for Public Comments)
- Di(2-ethylhexyl)phthalate (DEHP) (Updated) (PB2003-100138)
- Di-n-butyl Phthalate (Updated) (PB/2001/109104/AS)
- Di-n-octylphthalate (DNOP) (PB/98/101033/AS)*
- Diazinon (Updated) (PB2009-100003)
- Dichlorobenzenes (Updated) (PB2007-100672)
- Dichloropropenes (Updated) (PB2009-100004)
- Dichlorvos (PB/98/101124/AS)
- Diethyl phthalate (PB/95/264214/AS)*
- Diisopropyl Methylphosphonate (DIMP) (PB/99/102535/AS)*
- Dinitrocresols (Updated) (PB/95/264321)
- Dinitrophenols (PB/95/264339)
- Dinitrotoluenes (Updated)
- Disulfoton (PB/95/264347)
E
- Endosulfan (Updated) (Final)
- EndrinEndrin aldehyde (Updated) (PB/97/121040/AS)
- Ethion (PB/2000/108024)
- Ethylbenzene (PB2010-100004)
- Ethylene Glycol (PB2010-100005)
- Ethylene Oxide (PB/91/180554/AS)
F
- Fluorides, Hydrogen Fluoride, and Fluorine (Updated) (PB2004-100002)
- Formaldehyde (PB/99/166654)
- Fuel Oils / Kerosene (PB/95/264222/AS)*
G
- Gasoline, Automotive (PB/95/264206/AS)*
- Glutaraldehyde (Draft for Public Comments)
- Guthion (PB2009-100005)
H
- 2-Hexanone (Updated) (PB/93/110773/AS)
- Heptachlor/Heptachlor Epoxide (Updated) (PB2008-100005)
- Hexachlorobenzene (Updated) (Final)
- Hexachlorobutadiene (PB/95/100160/AS)
- Hexachlorocyclohexane (HCH) (Updated) (PB2006-100003)
- Hexachlorocyclopentadiene (HCCPD) (PB/99/166670)
- Hexachloroethane (PB/98/101041/AS)*
- Hexamethylene Diisocyanate (HDI) (PB/99/102543/AS)*
- HMX (Octogen) (PB/98/101058/AS)*
- Hydraulic Fluids (PB/98/101066/AS)*
- Hydrazines (PB/98/101025/AS)*
- Hydrogen Sulfide Carbonyl Sulfide (Updated) (Draft for Public Comment)
- n-Hexane (PB/99/166688)
J
- Jet Fuels JP-4 and JP-7 (PB/95/264230/AS)*
- JP-5, JP-8, and Jet A (Updated) (Draft for Public Comment)*
M
- 4,4'-Methylenebis(2-Chloroaniline)(MBOCA) (PB/95/100186/AS)
- 4,4'-Methylenedianiline (PB/99/102568/AS)*
- Malathion (PB2004-100003)
- Manganese (Updated) (PB2013-105793)
- Mercury (Updated) (PB/99/142416)
- Methoxychlor (Updated) (PB2003-100140)
- Methyl Mercaptan (PB/93/110799/AS)
- Methyl Parathion (PB/2001/109105/AS)
- Methyl tert-Butyl Ether (MTBE) (PB/97/121016/AS)
- Methylene Chloride (Updated) (PB/2000/108026)
- Mirex (PB/95/264354)
N
- n-Nitrosodi-n-propylamine (PB/90/180258/AS)
- n-Nitrosodimethylamine (PB/90/182130/AS)
- n-Nitrosodiphenylamine (Updated) (PB/93/182509/AS)
- Naphthalene, 1-Methylnapthalene, 2-Methylnapthalene (Updated) (PB2006-100004)
- Nickel (Updated) (PB2006-100005)
- Nitrate and Nitrite (Draft for Public Comment)
- Nitrobenzene (PB/91/180398/AS)
- Nitrophenols (PB/93/110823/AS)
P
- Parathion (Draft for Public Comment)
- Pentachlorophenol (Updated) (PB/2001/109106/AS)
- Perchlorates (Updated) (PB2009-100006)
- Perfluoroalkyls (Draft for Public Comments)
- Phenol (Updated) (PB2009-100007)
- Phosphate Ester Flame Retardants (PB2013-105796)
- Plutonium (Updated) (PB2010-100006)
- Polybrominated Biphenyls (PBBs) (Updated) (PB2004-107334)
- Polybrominated Diphenyl Ethers (PBDEs) (Updated) (Draft for Public Comment)
- Polychlorinated Biphenyls (PCBs) (Updated) (PB/2000/108027)
- Polycyclic Aromatic Hydrocarbons (PAHs) (Updated) (PB/95/264370)
Acenaphthene, Acenaphthylene, Anthracene, Benzo(a)anthracene, Benzo(a)pyrene, Benzo(b)fluoranthene, Benzo(g,h,i)perylene, Benzo(k)fluoranthene, Chrysene, Dibenzo(a,h)anthracene, Fluoranthene, Fluorene, Indeno(1,2,3-cd)pyrene, Phenanthrene, Pyrene - Propylene Glycol (Updated) (PB2009-103929)*
- Pyrethrins and Pyrethroids (PB2004-100004)
- Pyridine (PB/93/110831/AS)
S
- Selenium (Updated) (PB2004-100005)
- Silver (PB/91/180430/AS)
- Stoddard Solvent (PB/95/264263)*
- Strontium (PB2004-104400)
- Styrene (PB2010-100007)
- Sulfur Dioxide (PB/99/122020)
- Sulfur Mustard (Updated) (PB2004-100006)
- Sulfur Trioxide & Sulfuric Acid (PB99/122038)
- Synthetic Vitreous Fibers (PB2004-107335)
T
- 1,1,1-Trichloroethane (Updated) (PB/95/264396)
- 1,1,2,2-Tetrachloroethane (Updated) (PB2009-100008)
- 1,1,2-Trichloroethane (PB/90/196411/AS)
- 1,2,3 Trichloropropane (PB/93/110872/AS)
- 1,3,5 Trinitrobenzene & 1,3 Dinitrobenzene (PB/95/264289/AS)*
(See 1,3-Dinitrobenzene) - 2,4,6-Trinitrotoluene (TNT) (PB/95/264297/AS)*
- Tetrachloroethylene (PERC) (Updated) (Draft for Public Comment)
- Tetryl (PB/95/264271/AS)*
- Thallium (PB/93/110856/AS)
- Thorium (PB/91/180448/AS)
- Tin and Compounds (Updated) (PB2006-100006)
- Titanium Tetrachloride (PB/98/101082/AS)*
- Toluene (Updated) (Draft for Public Comment)
- Toluene Diisocyanate / Methylenediphenyl Diisocyanate (Draft for Public Comment)
- Total Petroleum Hydrocarbons (TPH) (PB/99/163370)
- Toxaphene (Updated) (Final)
- Trichlorobenzenes (Final)
- Trichloroethylene (TCE) (Updated) (Draft for Public Comment)
- Tungsten (PB2006-100007)
Background
By Congressional mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) produces "toxicological profiles" for hazardous substances found at National Priorities List (NPL) sites. These hazardous substances are ranked based on frequency of occurrence at NPL sites, toxicity, and potential for human exposure. Toxicological profiles are developed from a priority list of 275 substances. ATSDR also prepares toxicological profiles for the Department of Defense (DOD) and the Department of Energy (DOE) on substances related to federal sites.
Toxicological profiles are developed in two stages:
(1) DRAFTS: The toxicological profiles are first produced as drafts. ATSDR announces in the Federal Register the release of these draft profiles for a 90 day public comment period. Request draft toxicological profiles from ATSDR's Division of Toxicology and Human Health Sciences.
(2) FINALS: After the 90 day comment period, ATSDR considers incorporating all comments into the documents. ATSDR finalizes the profiles.
NTIS address
NTIS distributes finalized toxicological profiles for a
fee. For more information, contact
National Technical Information Service
5285 Port Royal Road
Springfield, Virginia 22161
1-800-553 6847 or 703-605-6000
Web site: http://www.ntis.gov
Toxicological profiles (draft for public comment) - CERCLA Set 24
The public comment period has ended and the profile will be revised based on relevant public comments.
Toxicological profiles (draft for public comment) – CERCLA Set 26
- Glutaraldehyde
- Hydrogen Sulfide/Carbonyl Sulfide (Update)
- Parathion
- Tetrachloroethylene (Update)
- Trichloroethylene (Update)
The public comment period has ended and the profiles will be revised based on relevant public comments.
Toxicological profiles (draft for public comment) – CERCLA Set 27
- DEET
- Toluene Diisocyanate and Methylenediphenyl Diisocyanate
- Nitrates/Nitrites
- Toluene (Update)
- Polybrominated Diphenyl Ethers (Update) (Update)
- Molybdenum*
The public comment period has ended and the profiles will be revised based on relevant public comments.
*Molybdenum is on a modified schedule and still under development.
Toxicological profiles (under development) – CERCLA Set 28
- Antimony (Update)
- 2,4-D
- Glyphosate
- Silica
Department of Defense (draft for public comment) – DoD5
The public comment period has ended and the profile will be revised based on relevant public comments.
Department of Defense (draft for public comment) – DoD6
The public comment period has ended and the profile will be revised based on relevant public comments.
Toxicological profiles (under development) – CERCLA Set 29
- Bromodichloromethane (Update)
- Bromomethane (Update)
- 2-Hexanone (Update)
- S,S,S-Tributyl Phosphorotrithioate
Toxicological profiles (under development) – CERCLA Set 30
- 1,1-Dichloroethene (Update)
- 1,2-Dichloropropane (Update)
- DDT, DDD, DDE (Update)
- Di(2-ethylhexyl)phthalate (DEHP) (Update)
- Pyrethrins and Pyrethroids (Update)
Federal Register Notices:
- FRN Set 28 Candidates
- FRN Set 28 Selection [PDF, 192 KB]
- FRN Set 27 Drafts for Public Comment [PDF, 196 KB]
- FRN Set 29 Candidates [PDF, 196 KB]
- FRN for Glutaraldehyde [PDF, 185 KB]
- FRN for Jet Fuels & 1-Bromopropane [PDF, 187 KB]
Profile Development:
- Profile Development Guidance [PDF, 2 MB]
- Profile Development Guidance Exhibits [PDF, 1 MB]
- Profile Selection Criteria
- Federal Register Notice[PDF, 964 KB]
- Support Document [PDF, 2.6 MB]
Additional Resources:
- Public Health Statements (PHS) - The PHS are a series of summaries about hazardous substances taken from Chapter One of their respective ATSDR Toxicological Profiles.
- ATSDR ToxFAQsTM - The ToxFAQsTM are a series of 2-page fact sheets about hazardous substances
- ATSDR ToxGuidesTM - The ATSDR ToxGuidesTM are quick reference guides providing information such as chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels, children's health, and health effects.
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