The United States established diplomatic relations with Cameroon in 1960, following the independence of the French-administered part of the country. Cameroon has had two presidents since independence. U.S. relations with Cameroon are positive, although from time to time they have been affected by concerns over human rights abuses and the pace of political and economic liberalization.

The two countries are partners in addressing issues of democracy, regional security, environmental protection, public health, and economic development. The United States hopes to continue to work with Cameroon to consolidate democratic gains and economic growth, particularly as Cameroon embarks upon senatorial, municipal, and legislative elections planned for 2013. The United States supports Cameroon's efforts to strengthen electoral institutions, enhance transparency, and allow for contestation of results.