Biosurveillance primarily focuses on developing effective surveillance, prevention and operational capabilities for detecting and countering biological threats. S&T takes a system-level approach to integrating information into surveillance architectures, developing and testing advanced detection systems, and implementing a cross-domain focus on biological, chemical and agricultural threats.

The Enhanced Passive Surveillance program is working to further develop, demonstrate and deliver a proof-of-concept surveillance system for identifying endemic, trans-boundary and emerging disease outbreaks in livestock. This expanded system will integrate multiple surveillance data streams from varied sources in real-time, helping to determine baseline prevalence rates for observed animal health issues, track variations in animal health status and identify trigger points to alert officials for action.

The BioThreat Awareness APEX program will develop affordable, effective and rapid detection systems to provide advance warning of a biological attack at indoor, outdoor and national security events. The project will also engage local jurisdictions in the testing of integrated information sharing systems that ensure relevant data is quickly available to key decision makers during an event.