Prohibited Conduct and Disqualifications: If a driver engages in conduct prohibited by 49 CFR Part 382, Subpart B, does this also disqualify the driver from operating a commercial motor vehicle (CMV) over 10,000 pounds GVWR?

Yes, 49 CFR 382.501(c) provides that drivers who are disqualified pursuant to Part 382 are prohibited from operating both a CMV as defined in §382.107 (over 26,000 pounds), and as defined in §390.5 (over 10,000 pounds and operated in interstate commerce) and may be disqualified under § 391.41(12), (13).