The Eastern Regional Office, based in West Trenton, NJ, is comprised of personnel from the Office of Pipeline Safety and the Office of Hazardous Materials Safety. The office is charged with overseeing the safe and secure movement of daily shipments of hazardous materials by all modes of transportation, as well as ensuring the safe, reliable, and environmentally sound operation of the nation's pipeline infrastructure.

The area of responsibility for this region is listed above; however, the jurisdiction of PHMSA staff is nationwide and not limited to their regional area of responsibility.