The United States established diplomatic relations with Burkina Faso (then called Upper Volta) in 1960, following its independence from France. U.S. relations with Burkina Faso are excellent. In addition to regional peace and stability, U.S. interests in Burkina Faso are to promote continued democratization and greater respect for human rights and to encourage sustainable economic development. Countering terrorism and strengthening border security are of growing importance in Burkina Faso.

The United States and Burkina Faso engage in a number of military training and exchange programs, including in counterterrorism and humanitarian assistance. The country is contributing to the support of U.S. efforts in the Sahel. Burkina Faso is a partner in the Africa Contingency Operations Training and Assistance program for peacekeeping and is a member of the Trans-Sahara Counterterrorism Partnership.