The United States established diplomatic relations with Guinea-Bissau in 1975, following its independence from Portugal. Post-independence, the country has seen a mix of coups, attempted coups, civil war, assassinations, and democratic elections. The United States strongly condemned the April 2012 attempt by elements of the military to forcibly seize power, called for maximum restraint on all sides and the restoration of legitimate civilian leadership, and continues to work with its partners in the region and beyond as it monitors developments on the ground. Now that the Economic Community of West African States (ECOWAS) has returned Bissau-Guinean military factions to their barracks and a civilian government is in power, the United States is working with its partners and the Transitional Government of Guinea-Bissau to facilitate free and fair elections by Spring 2013, and to promote basic reforms on governance, justice, and economic development.

There is no U.S. Embassy in Guinea-Bissau. All official U.S. contact with Guinea-Bissau is handled by the U.S. Embassy in Senegal. Local employees staff the U.S. Office in Bissau, and U.S. diplomats from the Embassy in Dakar travel frequently to Bissau.