The value of synthetic chemistry is far-reaching, ranging from medicines to advanced materials. While the field has developed rapidly over the last century, major challenges remain including the slow pace of discovery and limited reproducibility and scalability once a promising new molecule is identified.
The DARPA Make-It program aims to address these challenges by developing technologies to accelerate chemical discovery and production beyond conventional batch-based capabilities by exploiting continuous synthetic approaches. The goal of Make-It is to develop a fully automated chemical synthesizer that can produce, purify, characterize and scale a wide range of small molecules. Make-It systems would likely include components for knowledge-based computational tools for reaction pathway prediction; algorithms for automation and process control; and interconnected fluidic modules for continuous synthesis, in-line characterization, purification and formulation. If realized, such a system would not only speed the pace of chemical innovation and small-molecule manufacturing, but would also provide an accessible chemical synthesis platform for non-specialists.
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