TIME ebola

Ebola Treatment Clinical Trials to Start in West Africa

Experimental trials to find an Ebola treatment will begin next month in West Africa

An international health organization that has been leading the fight against the Ebola outbreak said Thursday that it will start experimental trials of treatments in West Africa next month.

MORE: Ebola death toll passes 5,000

There is currently no known cure for the virus, which has claimed at least 5,160 lives in the current epidemic. Doctors Without Borders, along with three different research partners from Belgium, France, and the U.K., will be leading the trials, which will test two antiviral drugs in Guinea and an unconfirmed location. The third trial in Guinea’s capital, Conakry, will use the blood of recovered Ebola patients to treat sick patients.

The World Health Organization and regional health authorities are also collaborating with the research partners.

Conducting clinical trials during a humanitarian crisis is unprecedented but MSF and partners have set up the trials with exceptional speed in an attempt to quell an outbreak with a fatality rate of around 70%.

MORE: Republicans grill Obama officials on Ebola funding request

“We need to keep in mind that there is no guarantee that these therapies will be the miracle cure” says Dr Annick Antierens, coordinating Doctor Without Borders’ investigational partnerships. “But we need to do all we can to try the products available today to increase the chances of finding an effective treatment against Ebola.”

The trials are expected to begin in December and initial results could be available as early as February 2015.

TIME ebola

Ebola Death Toll Surpasses 5,000 Worldwide

A team transports a corpse for burial near an Ebola treatment center in Suakoko, Liberia, Oct. 5, 2014.
A team transports a corpse for burial near an Ebola treatment center in Suakoko, Liberia, Oct. 5, 2014. Daniel Berehulak—The New York Times/Redux

The latest update from the World Health Organization presents a mixed picture of the fight to contain the worst outbreak of Ebola on record

More than 5,000 people have died from the Ebola virus, marking a macabre waypost that coincides with the disease’s return to Mali and a pickup in its spread in Sierra Leone, according to a status update released Wednesday by the World Health Organization (WHO).

Ebola has killed 5,160 out of 14,098 people infected across eight countries, according to the group’s most recent update, which presents an uncertain stage — dented with disappointments but also peaked with some bright points — in its effort to bring the Ebola outbreak under control.

In one hopeful sign, the rate of Ebola transmission is no longer increasing at a national level in Guinea and Liberia, though some areas of both countries are still seeing an escalation.

Yet Sierra Leone, where 1,169 people have died, continues to weather “steep increases” in the number of cases, says the WHO. Some 421 new cases were reported in the nation in just one week in November alone.

And in Mali, which was thought to be Ebola-free after an infected toddler died there in October, at least one person has recently died from the virus, while two deaths are suspected to have also been from Ebola, according to the update. One of the suspected cases, a grand imam, was buried after a “ritual washing” and a funeral assembly attended by “many mourners,” the WHO says.

Meanwhile, the WHO has received just 49% of the $260 million it deems necessary to handle the Ebola outbreak, according to the group’s latest figures. Though an additional 15% of the total amount has been pledged to the organization, it is still wanting for 36% of the required sum.

Out of 4,611 hospital beds planned for Ebola treatment centers in the three hardest-hit West African nations, just 24% are operational, and only 4% of the some 2,636 beds planned for community care centers have been set up. Just 38% of the 370 or so burial teams the WHO plans to train are good to go.

Still, all districts in the affected countries are within 24-hour access of a laboratory clinic, and some 95% of people the WHO is monitoring for possible exposure are receiving daily communications, the organization says.

Read next: Ebola Treatment Clinical Trials to Start in West Africa

TIME ebola

Veterinarians Group Issues New Guidelines for Pets and Ebola

Beagle on Hind Legs with Paws on Kennel Bars
Cavan Images/Getty Images

Though the spread of the deadly virus hasn't been linked to animals

The American Veterinary Medical Association is urging pet owners to take an abundance of caution when dealing with Ebola, as the Centers for Disease Control and Prevention (CDC) is saying that animals have not contributed to the outbreak of the virus in West Africa.

Pets should be quarantined, according to vet group’s new guidelines issued this week, if they have been in close contact with someone infected with Ebola. If the pets test positive for the lethal virus, they should be put down.

While quarantined, the pets should be confined to a crate or kennel inside a secure facility and stripped of all clothing and collars that could have possibly been contaminated.

The recommendations reiterate that there have been no reports of dogs or cats stricken with the virus, not even in parts of Africa where the disease is rampant. In the U.S., the likelihood of pets getting the disease is very low, and the last known person in the U.S. to have been diagnosed with the virus was released from the hospital with an all clear on Tuesday.

The CDC and leading veterinarians began researching how to approach pets of people infected with Ebola after the dog of a nurse in Spain was put down when its owner contracted the virus.

TIME Companies

What Took Silicon Valley So Long to Join the Ebola Fight?

Silicon Valley's humanitarian aid doesn't normally come in the form of cash — it comes in the form of tech

Until last week, there was one group largely missing from the list of Ebola donors: Silicon Valley companies.

Facebook’s and Google’s donation campaigns arrived months into an outbreak that in early summer had already been deemed “the worst Ebola outbreak in history.” And while their giving initiatives are generous — Facebook leveraged valuable online real estate for donation banners, while Google has already raised $5.1 million with its double-matched donations — it’s hard not to ask a lingering question: Why not sooner?

The question has plagued most humanitarian efforts in the Ebola fight. The World Health Organization’s chief criticized the timing of international support, mostly from governments, NGOs and international groups, as being “too little, too late” as far back as September. Some critics have even stepped forward to blast Silicon Valley companies over their timing directly — a Washington Post column noted that multimillion dollar gifts from Silicon Valley figureheads like Mark Zuckerberg and Bill Gates highlighted the silence from the companies themselves. Another critic argued that Silicon Valley corporations, so-called promisers of change, were hypocritically “sitting out” the Ebola fight.

But companies like Facebook and Google weren’t really “sitting out.” Silicon Valley’s humanitarian aid doesn’t normally come in the form of cash — it comes in the form of tech. Google’s Ebola donation campaign was a product of its nonprofit arm, which funds innovative groups using technology to change the world, a Google spokesperson says. Facebook has used its site to show its massive audience how to support nonprofits fighting Ebola, says a spokesperson at the U.N. Foundation, which has worked with Facebook for months to promote Ebola aid.

Tech has been at the forefront of Silicon Valley’s aid in previous crises too. Google launched crisis maps to aid emergency preparedness and response, while Facebook’s social network, recently a platform for the ALS Ice Bucket Challenge fundraising phenomenon, has facilitated communication during disasters. Still, while both companies have used their platforms to invite donations in the past, like during last year’s Typhoon Haiyan in the Philippines, neither had ever asked their users for help so directly — especially Facebook, which just last week followed Google’s example and started asking users to donate to various humanitarian organizations. That move, a Facebook spokesperson says, was way to amplify Facebook’s other ongoing humanitarian-contribution efforts.

Facebook and Google’s Ebola donation requests are just two ground-level examples of humanitarian efforts from an industry that’s better known for long-term, moonshot-style tech for a cause. Google has plans for a pill that can diagnose cancer and a smart contact lens that monitors diabetics’ glucose level, for example, while Facebook is developing solar-powered drones that beam down Internet access to less developed regions of the world. And few people in the humanitarian community really expect Silicon Valley companies, flush with cash as they are, to solicit donations or shell out their own money, but they very much welcome Facebook and Google’s efforts here.

“Silicon Valley companies have been very generous, as companies, to respond to different disasters. But for them to take a public stand and campaign like they’ve done is unprecedented,” says Rebecca Milner, vice president of institutional advancement at International Medical Corps (IMC), one of three nonprofits on Facebook’s Ebola donation banner.

IMC and other public-health organizations say they don’t consider Facebook’s and Google’s efforts to be too late. That’s partly because Silicon Valley isn’t usually involved in large coordinated efforts with humanitarian organizations, which work mostly with governments, NGOs and nonprofits. But that’s something that’s starting to change. Still, health experts believe that looking back — especially tempting now when we hear the best time for aid would’ve been before the Ebola outbreak even began — isn’t as useful as discovering how Silicon Valley’s humanitarian-engagement methods can be a powerful tool in the Ebola fight moving forward.

“This is something we’ve been chasing the whole time, and it’s hard to get in front of,” says Kate Dodson, vice president of global health at the U.N. Foundation. “It’s a learning process for all of us who are trying to support those on the front lines of the Ebola response.”

TIME Research

Speaking More Than One Language Could Sharpen Your Brain

Skip the sudoku, try learning French

Speaking more than one language does the brain some good.

A recent study found that bilingual speakers may actually process information more efficiently than single-language speakers. Researchers from Northwestern University and University of Houston used brain imaging to look at bilingual people’s comprehension abilities. They found that people who speak more than one language are comparatively better at filtering out unnecessary words than monolinguals, whose brains showed that they had to work harder to complete the same mental tasks.

The study, published in the journal Brain and Language, used functional magnetic resonance imaging (fMRI) to look at what’s called coactivation and inhibition in the brain. Coactivation is the ability to have both languages simultaneously active in the brain and inhibition is that ability to select a correct language while hearing more than one at a time. The researchers studied 17 Spanish-English bilinguals and 18 monolinguals, and had them undergo tests that assessed their brains’ ability to eliminate irrelevant words.

For example, in one task the participants heard the word “cloud” and were then immediately shown four pictures. One of the photos was of a cloud, and another was a similar-sounding word like clown. The goal was to watch how quickly the brain could make connections to the correct word. Bilinguals were consistently better at the task.

The results create a bit of a chicken-or-the-egg scenario. Is a bilingual person better at such tasks due to their expertise in both languages, or are people with greater comprehension capacity better equipped to master multiple languages? It could be a mixture of the two. The researchers of the new study believe that being bilingual is a constant brain exercise. So instead of tackling a puzzle, why not give a new language a shot, if not solely for the brain challenge.

TIME ebola

Ebola Victim’s Family and Dallas Hospital Reach Settlement

Ebola Monitoring
Texas Health Presbyterian Hospital in Dallas where Thomas Eric Duncan the first Ebola patient diagnosed in the U.S. received care on Sept. 30, 2014. LM Otero—AP

The hospital will also help create a foundation in Thomas Eric Duncan's name

The family of the first patient diagnosed with Ebola in the United States announced Wednesday that a settlement had been reached with the Dallas hospital that treated him before his death.

The deal with Texas Health Presbyterian Hospital was “as good or better than we would have done in court,” Les Weisbrod, a lawyer for the family of Thomas Eric Duncan, said at a news conference.

Medical malpractice suits in Texas have an upper liability limit of $250,000 for a claimant. If the Duncan family had taken the hospital to court, it would have had to reach a very high legal bar, proving the hospital knew its staff was causing harm when they treated Duncan.

Staffers at Texas Health Presbyterian had originally sent Duncan home after he went to the emergency room, even though he had a fever and was recently in Liberia, among the three hardest-hit nations in an outbreak that has killed more than 5,000 people. He died Oct. 8; two nurses who were a part of Duncan’s medical team would later contract Ebola but, after treatment elsewhere, be declared virus-free.

The hospital has also agreed to create a foundation in Duncan’s name to fund the construction of a facility to combat Ebola in Liberia. The fund will be administered by one of the existing foundations of Texas Health Resources, and the family said it is seeking contributions.

“I can never replace Thomas Eric Duncan, but we can make sure that we make this better for everyone else,” said Josephus Weeks, Duncan’s nephew.

TIME Diet/Nutrition

6 Ways You’re Using Olive Oil Wrong

Bubbles in olive oil
Getty Images

A slightly bitter taste can indicate the presence of antioxidants

Everyone knows olive oil is great for your health and a staple of the Mediterranean diet. But even though it’s now found in most kitchens, it’s still steeped in mystery and confusion. Read on for some of the biggest mistakes people make with olive oil, and how to use it correctly.

1. You buy the “light” version to save calories

All olive oils have roughly the same amount of calories and fat (about 120 calories and 14g fat per tablespoon). “Light” refers to the color and flavor of this oil, which is highly refined to make it more neutral than other types of olive oil.

HEALTH.COM: 9 Low-Fat Foods You Shouldn’t Eat

2. You’re afraid to cook with the extra-virgin stuff.

It’s true that extra virgin olive oil has a lower smoke point than other types of olive oil and some other fats—that is, the temperature where oil begins to smoke and impart an unpleasant odor and flavor (peanut oil is 450ºF and grapeseed is 445ºF, for example. For more, check out this chart on Serious Eats). Extra virgin olive oil has a smoke point around 410ºF, according to The Science of Good Food, so it’s perfectly safe for sautéing at medium temperatures. Extra virgin is the purest form of olive oil, and contains the most health supportive oleic acid so there’s no need to use it only for salad dressing.

3. You toss any that tastes slightly bitter.

Don’t toss that oil just yet: it may not have gone bad. A slightly bitter taste can indicate the presence of antioxidants, according to researchers at the University of California, Davis, Olive Center. With a fresh extra virgin olive oil, you should taste, well, olives, and also some grassy or fruity notes.

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4. You keep it right next to the stove.

Nothing will make your olive oil go rancid quicker than heat and light. Look for olive oil in a dark-colored glass or tin container, and store it in a cool spot, away from sunlight.

5. You stock up when you see a great deal.

Unless you’ll use it all quickly, it’s better to buy olive oil in smaller quantities. Ideally you want to use it up within about 6 weeks.

6. You use the “fridge test” to see if yours is high quality.

Sorry, but no. After a 2013 episode of the Dr. Oz Show, in which he claimed you can test to see how pure your olive oil is by refrigerating it (if it solidifies in the fridge, it’s pure), UC Davis researchers put the fridge test to the test, and it flunked. That is, if an olive oil turns to a solid at lower temperatures, it doesn’t mean it’s of higher quality.

The best way to ensure your oil is good quality? Look for seals on the bottle from the USDA Quality Monitoring Program, the North American Olive Oil Association, the California Olive Oil Council, or the Extra Virgin Alliance.

HEALTH.COM: 14 Clever Cooking Hacks That Will Change Your Life

This article originally appeared on Health.com

TIME global health

Plant-Based Diet Is Best for the Planet, New Science Says

vegetables
Getty Images

Alternative diets could, if widely adopted, reduce global agricultural greenhouse gas emissions

Good food advocates have long argued that what’s good for your health is also good for the planet, but new science now backs up the claim. A paper published in the journal Nature by scientists at the University of Minnesota, presents numbers that suggest eating less meat, less refined fat, and less sugar will also reduce the climate change impacts of food production.

Using about 50 years’ worth of data from the world’s 100 most populous countries, UM Professor of Ecology G. David Tilman and graduate student Michael Clark show how current diet trends are contributing, not only to diet-related illnesses such as diabetes and heart disease, but also to dangerously increasing agricultural greenhouse gas emissions (GHGs).

“This is the first time this data has been put together to show these links are real and strong and not just the mutterings of food lovers and environmental advocates,” explains Tilman.

“Alternative diets that offer substantial health benefits could, if widely adopted, reduce global agricultural greenhouse gas emissions, reduce land clearing and resultant species extinctions, and help prevent such diet-related chronic non-communicable diseases,” write Tilman and Clark in the Nature article.

Agriculture currently contributes about 25 percent of the GHG emissions that are driving climate change. Grain-based livestock production–which involves clearing land and raising grain for animal feed, particularly in the world’s tropical regions–contribute more than 75 percent of those emissions.

As the rest of the world adopts American dietary habits, the rates of meat, sugar, and processed food consumption have been on to rise. (In China alone, the numbers have skyrocketed.) If the trend continues, all those burgers and pork chops are projected to be responsible for an 80 percent increase in agricultural GHG emissions by 2050.

At the same time, thanks to the exporting of American dietary habits, more than 2.1 billion of the world’s 7.2 billion people are now either overweight or obese. Tilman explains that “empty calories”—sugar, fat, oils and alcohol—now account for almost 40 percent of food purchased in the world’s 15 wealthiest countries, which helps explain the resulting health effects.

According to the data Tilman and Clark examined, which corrected for other lifestyle factors, a vegetarian diet reduced incidence of type II diabetes by 41 percent, followed by a vegetarian diet that includes seafood (25 percent), and a Mediterranean diet that combines moderate meat consumption and is rich in fruit, vegetables, and seafood (16 percent). All three diets appeared to reduce coronary heart disease deaths between 20 and 26 percent and cancer rates by between 7 and 13 percent compared to diets that included at least twice as much meat and processed foods.

Tilman and Clark caution that while the links between what makes healthy diet and what will help lower agricultural greenhouse gas emissions are clear, it’s also possible to eat “a pure junk food diet,”–think French fries, donuts, and tortilla chips–that has low GHG emissions.

So the solution to what the scientists call the “diet-environment-health trilemma” will require choosing menus high in plant-based, whole foods like those that fit in a Meditarrean, “pescetarian” or vegetarian diet. If these diets become the norm by 2050, Tilman and Clark say “there would be no net increase in food production emissions.”

But they also note that making such a change won’t necessarily be easy. “The dietary choices that individuals make are influenced by culture, nutritional knowledge, price, availability, taste and convenience, all of which must be considered if the dietary transition that is taking place is to be counteracted,” write Tilman and Clark.

So, how do we counter the trend toward eating more meat and fatty food? “There are lots of policy options,” says Doug Boucher, director of climate research at the Union of Concerned Scientists. These include carbon taxes that would include agriculture as New Zealand now does, shifting agricultural subsidies away from livestock and related feed production, and changing government dietary guidelines to include sustainability and climate change considerations, as the U.S. Department of Agriculture’s (USDA) 2015 guidelines are expected to.

The USDA’s climate change program director, William Hohenstein, explains that rather than addressing the “trilemma” by focusing on the menu, the agency’s preferred strategy is to work with growers and livestock producers on practices that will reduce GHGs. “Consumers always have a choice,” says Hohestein.

Tilman suggests “better education” is key to helping people of all income levels understand the impacts of their food choices. He also wonders if, given the clear trend toward convenience foods, it might be possible to develop new food that is healthy, low-carbon and he adds, “also tastes good.”

Meanwhile, the data strongly suggest that eating more like Bill Clinton post-heart surgery will not only improve personal and public health, but also help put the planet on a much needed version of a weight-reduction program for greenhouse gasses.

This story originally appeared on Civil Eats

TIME Exercise/Fitness

You Asked: Is Running on a Treadmill as Good as Running Outside?

runnig on a treadmill or outside
Illustration by Peter Oumanski for TIME

Nope—but it can come pretty close with one small tweak

To dedicated runners, running outside gets all the glory. Some purists even eschew headphones (and shoes!). But when talking about whether treadmill running is “the same” as running outdoors, it helps to pinpoint what sort of sameness matters to you.

In terms of the mechanics of your stride, there’s not much difference between running on a treadmill and running on ground, says Dr. Irene Davis, a professor of physical medicine and rehabilitation at Harvard Medical School who has studied the differences between treadmill and over-ground running. “While it feels much different to you, the leg motions and the forces experienced by your body are very similar between these conditions,” Davis says.

But when it comes to your risk for injuries, there may be an important difference. “Most running injuries are overloading injuries that involve muscle, cartilage, bone or tendons wearing down over time,” Davis explains. While there isn’t a lot of good research on this, Davis says those types of injuries probably occur more frequently when you repeat the exact same running motion thousands and thousands of times—as you would on a treadmill or a flat, consistent stretch of pavement.

“You strike the ground 1,000 times per foot, per mile,” she says. And if you’re running on a treadmill or a flat, hard surface, the redundancy of your motion increases your risk for these overuse injuries.

On the other hand, Davis suspects that changing up your stride has a beneficial effect on your injury risk. The more you move in response to curbs, corners, hills or leashed pets, the less likely you are to overburden the same muscle or tendon. Running courses that include lots of slopes, speed changes, and impediments—especially nature trails—are probably safest when it comes to your risk for wear and tear, she hypothesizes.

But what about the effort involved in running outdoors as opposed to on a treadmill? The big factor here is “air resistance,” which you’ll encounter more of outdoors than you will inside, finds a much-cited study from the University of Brighton in the UK. But there’s an easy fix for treadmill runners: By raising the grade of your belt very slightly—just 1% of added incline—you’ll mimic the effects of outdoor air resistance, the study authors conclude.

There may also be a psychological factor to the debate. Lots of research has found that time spent outside, especially in green spaces like woods or parks, offers benefits ranging from improved mood and energy levels to better sleep. And another UK study—this one from the universities of Exeter and Essex—found that runners who ran outdoors in natural environments reported greater feelings of revitalization and wellbeing, and decreases in tension, confusion, anger and depression. (Just don’t forget sun protection.)

All things considered, running outdoors and on trails makes the most sense for maximizing the benefits of running. But if the weather’s bad or a treadmill is your only option, don’t sweat it. It may be an inferior alternative, but only slightly so.

TIME Sex/Relationships

Watch How These People Learned About Sex

Dr. Ruth and others share their stories

In spring 2014, parents in the normally progressive Bay Area city of Fremont started a campaign to get a book removed from the 9th grade curriculum, arguing it was inappropriate for their 13 and 14-year olds. They hired a local lawyer and put together a petition with more than 2500 signatures.

Their target was Your Health Today, a sex-ed book published by McGraw Hill. It offers the traditional advice and awkward diagrams plus some considerably more modern elements: how to ask partners if they’ve been tested for STDs, a debate on legalizing prostitution. And then there was this: “[One] kind of sex game is bondage and discipline, in which restriction of movement (e.g. using handcuffs or ropes) or sensory deprivation (using blindfolds or masks) is employed for sexual enjoyment. Most sex games are safe and harmless, but partners need to openly discuss and agree beforehand on what they are comfortable doing.”

“I was just astounded,” says Fremont mom Teri Topham. “My daughter is 13. She needs to know how boys feel. I frankly don’t want her debating with other 13-year-olds how well the adult film industry is practicing safe sex.” Another parent, Asfia Ahmed, who has eight and ninth grade boys, adds: “It assumes the audience is already drinking alcohol, already doing drugs, already have multiple sexual partners…Even if they are experimenting at this age, it says atypical sexual behaviors are normal. ”

But school board members contend that 9th grade students have already been exposed to the contents of the book—and much, much more. They argue that even relatively modern sex ed has even not begun to reckon with what kids are now exposed to in person and online.

Read more here.

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