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In the Current Issue 12 February 2013 (Issue 262)

DNA replication

Featured Connections Map:
Hypoxia-Inducible Factor 1 (HIF-1) Pathway

Browse all Pathways »

Research Articles

A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication: Maimon E. Hubbi, Kshitiz, Daniele M. Gilkes, Sergio Rey, Carmen C. Wong, Weibo Luo, Deok-Ho Kim, Chi V. Dang, Andre Levchenko, and Gregg L. Semenza
Editor's Summary | Abstract | Full Text | PDF | Supplementary Materials

ERK-Mediated Phosphorylation of Fibroblast Growth Factor Receptor 1 on Ser⁷⁷⁷ Inhibits Signaling: Malgorzata Zakrzewska, Ellen Margrethe Haugsten, Beata Nadratowska-Wesolowska, Angela Oppelt, Barbara Hausott, Yixin Jin, Jacek Otlewski, Jørgen Wesche, and Antoni Wiedlocha
Editor's Summary | Abstract | Full Text | PDF | Supplementary Materials

Perspective

Of Proneurotrophins and Their Antineurotrophic Effects: Lucy Kotlyanskaya, Kristina A. McLinden, and Edward Giniger
Abstract | Full Text | PDF

Podcast

Science Signaling Podcast: 12 February 2013: Gregg L. Semenza, Maimon E. Hubbi, and Annalisa M. VanHook
Abstract | Full Text | Podcast

ST NetWatch

Protein Databases: Structure-Function Linkage Database (SFLD)
Description

Bioinformatics Resources: Progenetix
Description

Editors' Choice

A Tail of ROS: N. R. Love et al., Nat. Cell Biol. 15, 222–228 (2013).; Read this Summary | Read all Summaries

In Literature

What's Hot: Read this highly accessed article published recently in a previous issue:
RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage
Abstract | Full Text
Virtual Journal: Check out this article, just added to the Virtual Journal:
Jack of All Trades, Master of Flowering
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Related to Science: Find articles and resources that complement special issues or particular articles in Science.
Featured in Science: Find Science Signaling articles featured in the Editors' Choice section of Science Magazine.
Science Signaling Preview: Get an advanced peek at abstracts of upcoming Science Signaling articles.
Issue Archive: Access the table of contents of back issues of Science Signaling (a continuation of Science's STKE).

In Community

Events, Meeting Reports, and Presentations: Check out the calendar, read highlights, and view presentations of cell signaling meetings and conferences.
Directory: Featured person: Anne A. Knowlton. Find collaborators and people with shared research interests—join the Signaling community and add your information to the Directory!
Forums: Share highlights from signaling meetings or read the recent posting "Linking Cancer and Metabolism" in Meeting Highlights.
E-Letters: Featured E-Letter: No Connection Intended. Find out how to submit a comment to make Science Signaling a rich community by contributing your knowledge. For example, share your experiences with a method described in a Protocol; tell other teachers how you used Teaching Resources; alert the community to research related to those highlighted in Editors' Choice; comment on or ask the authors about their articles.

In Resources

Teaching Resources: Featuring the course "Systems Biology—Biomedical Modeling," explore this and other materials for teachers.
Glossary: Find out what those acronyms and abbreviations mean. Browse or search the glossary of cell signaling terms. Look at the list of the most recently added terms.
Podcasts: Tune-in for a portable and understandable summary of selected cell signaling research. Check out each episode of the Science Signaling Podcast.
ST NetWatch: Featured in Protein Databases: Structure-Function Linkage Database (SFLD). Explore the sites selected by the editors or submit your favorite signal transduction Web site.
Funding Sources: Check out the opportunities for funding cell signaling research and training.
Jobs: Search or browse employment opportunities related to signal transduction in Science Careers.

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