PLOS Genetics: A Peer-Reviewed Open-Access Journal

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Rare Copy Number Variants Are a Common Cause of Short Stature
Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response
Crif1 Deficiency Reduces Adipose OXPHOS Capacity and Triggers Inflammation and Insulin Resistance in Mice
Heteroduplex DNA Position Defines the Roles of the Sgs1, Srs2, and Mph1 Helicases in Promoting Distinct Recombination Outcomes
Deficiency in Origin Licensing Proteins Impairs Cilia Formation: Implications for the Aetiology of Meier-Gorlin Syndrome

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Featured Discussions

Interview

Problem Solved: An Interview with Sir Edwin Southern

Jane Gitschier speaks to Edwin Southern, inventor of the Southern blot used to transfer DNA from gels onto nitrocellulose paper. One of the first to sequence eukaryotic DNA and to appreciate the genetic architecture of satellite DNAs, he was also a strong and productive proponent of physical mapping of the human genome as a complement to the genetic map.

Featured Research

Mechanistic Insight into the Pathology of Polyalanine Expansion Disorders Revealed by a Mouse Model for X Linked Hypopituitarism

To investigate the pathological mechanism of polyalanine (PA) disorders, these authors generated a mouse model of X-linked Hypopituitarism, a disease caused by PA expansion in the SOX3 protein.

A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan

These authors employed an outbred Saccharomyces cerevisiae model to identify quantitative trait loci that control replicative lifespan, and find that calorie restriction conditions also reduce rDNA replication, potentially promoting longevity by the same mechanism.

Estrogen Mediated-Activation of miR-191/425 Cluster Modulates Tumorigenicity of Breast Cancer Cells Depending on Estrogen Receptor Status

These authors demonstrated that the miR-191/425 cluster, by reducing the expression of an extensive network of genes, has a fundamental impact on cancer initiation and progression of breast cancer cells.

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PLOS Genetics is a peer-reviewed, open-access journal that reflects the full breadth and interdisciplinary nature of genetics and genomics research by publishing outstanding original contributions in all areas of biology.